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PMID: 10547254 Published · ppublish English Case Reports Journal Article

Viral infections in interferon-gamma receptor deficiency.

The Journal of pediatrics ·Vol. 135 ·No. 5 ·1999-11-00 ·Pages 640-3

Dorman SE, Uzel G, Roesler J, Bradley JS, Bastian J, Billman G, King S, Filie A, Schermerhorn J, Holland SM

Abstract

Interferon-gamma receptor deficiency is a recently described immunodeficiency that is associated with onset of severe mycobacterial infections in childhood. We describe the occurrence of symptomatic and often severe viral infections in 4 patients with interferon-gamma receptor deficiency and mycobacterial disease. The viral pathogens included herpes viruses, parainfluenza virus type 3, and respiratory syncytial virus. We conclude that patients with interferon-gamma receptor deficiency and mycobacterial disease have increased susceptibility to some viral pathogens.

MeSH Terms
Antigens, CD/genetics Child Child, Preschool Female Humans Immunologic Deficiency Syndromes/genetics,immunology Infant Male Mycobacterium Infections/immunology Phenotype Receptors, Interferon/deficiency,immunology Virus Diseases/immunology
Chemicals
Antigens, CD Receptors, Interferon interferon gamma receptor
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Dorman S E
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, Department of Pathology, National Institutes of Health, Bethesda, Maryland 20892, USA.
Uzel G
Roesler J
Bradley J S
Bastian J
Billman G
King S
Filie A
Schermerhorn J
Holland S M
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Article Info
Journal
The Journal of pediatrics
Abbr.
J Pediatr
ISSN
0022-3476
DOI
10.1016/s0022-3476(99)70064-8
Published
1999-11-00
Pages
640-3
Language
English
Region
United States
NLM ID
0375410
PMCID
PMC7095028
Subset
IM
Corrections
CommentIn
PMID: 10547240
External Links
PubMed source DOI: 10.1016/s0022-3476(99)70064-8 PMC Full Text View journal details
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