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PMID: 10729167 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Control of Sindbis virus infection by antibody in interferon-deficient mice.

Journal of virology ·Vol. 74 ·No. 8 ·2000-04-00 ·Pages 3905-8

Byrnes AP, Durbin JE, Griffin DE

Abstract

Antibodies clear Sindbis virus from infected animals through an unknown mechanism. To determine whether interferon-induced pathways are required for this clearance, we examined mice which are unable to respond to alpha/beta interferon or gamma interferon. Although extremely susceptible to infection, such mice survived and completely cleared virus if antibodies against Sindbis virus were given.

MeSH Terms
Aging Alphavirus Infections/immunology,mortality,virology Animals Antibodies, Monoclonal/immunology Antibodies, Viral/immunology Central Nervous System/virology Central Nervous System Viral Diseases/immunology,mortality,virology Interferon-alpha/deficiency,physiology Interferon-beta/deficiency,physiology Mice Mice, Inbred C57BL Sindbis Virus/immunology,physiology Viral Load Virus Replication
Chemicals
Antibodies, Monoclonal Antibodies, Viral Interferon-alpha Interferon-beta
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Byrnes A P
Department of Molecular Microbiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA.
Durbin J E
Griffin D E
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/jvi.74.8.3905-3908.2000
Published
2000-04-00
Pages
3905-8
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC111901
Subset
IM
Grants
NINDS NIH HHS · R01 NS018596 · United States
NINDS NIH HHS · R01-NS18596 · United States
External Links
PubMed source DOI: 10.1128/jvi.74.8.3905-3908.2000 PMC Full Text View journal details
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