Home LiteratureArticle Details
PMID: 9765476 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Murine coronavirus-induced subacute fatal peritonitis in C57BL/6 mice deficient in gamma interferon.

Journal of virology ·Vol. 72 ·No. 11 ·1998-11-00 ·Pages 9286-90

Kyuwa S, Tagawa Y, Shibata S, Doi K, Machii K, Iwakura Y

Abstract

Gamma interferon-deficient (IFN-gamma-/-) mice with a C57BL/6 background were infected intraperitoneally with mouse hepatitis virus strain JHM (JHMV). In contrast to IFN-gamma-+/- and IFN-gamma+/+ mice, JHMV persisted in IFN-gamma-/- mice and induced death during the subacute phase of the infection. Unexpectedly, infected IFN-gamma-/- mice showed severe peritonitis accompanying the accumulation of a viscous fluid in the abdominal and thoracic cavities in the subacute phase. Destructive changes of hepatocytes were not observed. Administration of recombinant IFN-gamma protracted the survival time of IFN-gamma-/- mice after JHMV infection. These results demonstrate that IFN-gamma plays a critical role in viral clearance in JHMV infection. They also show that a resultant persistent JHMV infection induces another form of disease in IFN-gamma-/- mice, which bears a resemblance to feline infectious peritonitis in cats.

MeSH Terms
Alanine Transaminase/blood Animals Cats Coronavirus Infections/etiology,immunology,virology Feline Infectious Peritonitis/immunology,therapy Female Immunity, Cellular Interferon-gamma/deficiency,genetics,pharmacology Liver/pathology,virology Mice Mice, Inbred C57BL Mice, Knockout Murine hepatitis virus/pathogenicity Peritonitis/etiology,immunology Recombinant Proteins T-Lymphocytes/immunology
Chemicals
Recombinant Proteins Interferon-gamma Alanine Transaminase
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Kyuwa S
Department of Animal Pathology, Institute of Medical Science, University of Tokyo, Tokyo 108, Japan. kyuwa@gpo.kumamoto-u.ac.jp
Tagawa Y
Shibata S
Doi K
Machii K
Iwakura Y
References (34)
34 references, click to expand
  1. A new colorimetric ultramicromethod for serum glutamic-oxalacetic and glutamic-pyruvic transaminase determination.
    Clin Chim Acta. 1970 Jun;28(3):431-7 PMID: 5450168
  2. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes.
    Immunity. 1996 Jan;4(1):25-36 PMID: 8574849
  3. The JHM strain of mouse hepatitis virus induces a spike protein-specific Db-restricted cytotoxic T cell response.
    J Gen Virol. 1996 Feb;77 ( Pt 2 ):315-25 PMID: 8627236
  4. Role of CD4+ and CD8+ T cells in mouse hepatitis virus infection in mice.
    Exp Anim. 1996 Jan;45(1):81-3 PMID: 8689585
  5. In vivo blockade of gamma interferon affects the influenza virus-induced humoral and the local cellular immune response in lung tissue.
    J Virol. 1996 Jul;70(7):4411-8 PMID: 8676464
  6. Exacerbated viral hepatitis in IFN-gamma receptor-deficient mice is not suppressed by IL-12.
    J Immunol. 1996 Jul 15;157(2):815-21 PMID: 8752933
  7. Characterization of T cells expanded in vivo during primary mouse hepatitis virus infection in mice.
    J Vet Med Sci. 1996 May;58(5):431-7 PMID: 8741603
  8. Cytotoxic T cell-resistant variants are selected in a virus-induced demyelinating disease.
    Immunity. 1996 Sep;5(3):253-62 PMID: 8808680
  9. Mouse hepatitis virus is cleared from the central nervous systems of mice lacking perforin-mediated cytolysis.
    J Virol. 1997 Jan;71(1):383-91 PMID: 8985361
  10. Disassociation between the in vitro and in vivo effects of nitric oxide on a neurotropic murine coronavirus.
    J Virol. 1997 Mar;71(3):2202-10 PMID: 9032354
  11. Roles of IL-4 and IFN-gamma in stabilizing the T helper cell type 1 and 2 phenotype.
    J Immunol. 1997 Mar 15;158(6):2648-53 PMID: 9058797
  12. Gamma interferon is not essential for recovery from acute infection with murine gammaherpesvirus 68.
    J Virol. 1997 May;71(5):3916-21 PMID: 9094668
  13. Cellular responses to interferon-gamma.
    Annu Rev Immunol. 1997;15:749-95 PMID: 9143706
  14. Enterotropic mouse hepatitis virus.
    Lab Anim. 1997 Apr;31(2):97-115 PMID: 9175007
  15. Kinetics of cytokine mRNA expression in the central nervous system following lethal and nonlethal coronavirus-induced acute encephalomyelitis.
    Virology. 1997 Jul 7;233(2):260-70 PMID: 9217050
  16. Expression of interferon-gamma by a coronavirus defective-interfering RNA vector and its effect on viral replication, spread, and pathogenicity.
    Virology. 1997 Jul 7;233(2):327-38 PMID: 9217056
  17. Suppression of concanavalin A-induced hepatitis in IFN-gamma(-/-) mice, but not in TNF-alpha(-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes.
    J Immunol. 1997 Aug 1;159(3):1418-28 PMID: 9233639
  18. Cytotoxic T-cell-resistant variants arise at early times after infection in C57BL/6 but not in SCID mice infected with a neurotropic coronavirus.
    J Virol. 1997 Oct;71(10):7640-7 PMID: 9311846
  19. Mouse susceptibility to mouse hepatitis virus infection is linked to viral receptor genotype.
    J Virol. 1997 Nov;71(11):8860-3 PMID: 9343248
  20. CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides.
    Science. 1997 Nov 28;278(5343):1626-9 PMID: 9374463
  21. The relative role of lymphocyte granule exocytosis versus death receptor-mediated cytotoxicity in viral pathophysiology.
    J Virol. 1998 Jan;72(1):1-9 PMID: 9420194
  22. Ascitic disease in ICR-nude mice due to mouse hepatitis virus.
    Nihon Juigaku Zasshi. 1986 Feb;48(1):7-14 PMID: 3007841
  23. Pathogenicity of antigenic variants of murine coronavirus JHM selected with monoclonal antibodies.
    J Virol. 1986 Jun;58(3):869-75 PMID: 3701929
  24. Site-specific alteration of murine hepatitis virus type 4 peplomer glycoprotein E2 results in reduced neurovirulence.
    J Virol. 1986 Aug;59(2):463-71 PMID: 3016306
  25. Effect of sensitized T cell transfer on mouse hepatitis virus type 4 infection in athymic nude mice.
    Nihon Juigaku Zasshi. 1989 Feb;51(1):219-21 PMID: 2538671
  26. Effective clearance of mouse hepatitis virus from the central nervous system requires both CD4+ and CD8+ T cells.
    J Virol. 1990 Sep;64(9):4589-92 PMID: 2166833
  27. The role of gamma interferon in infection of susceptible mice with murine coronavirus, MHV-JHM.
    Arch Virol. 1991;121(1-4):89-100 PMID: 1662041
  28. Expression of cytokines by recombinant vaccinia viruses: a model for studying cytokines in virus infections in vivo.
    Immunol Rev. 1992 Jun;127:157-82 PMID: 1354650
  29. The cellular and molecular pathogenesis of coronaviruses.
    Lab Anim Sci. 1993 Feb;43(1):15-28 PMID: 8384676
  30. Cytokine induction during T-cell-mediated clearance of mouse hepatitis virus from neurons in vivo.
    J Virol. 1994 Sep;68(9):5483-95 PMID: 8057431
  31. Apoptosis induced in mouse hepatitis virus-infected cells by a virus-specific CD8+ cytotoxic T-lymphocyte clone.
    J Virol. 1994 Nov;68(11):7540-5 PMID: 7933139
  32. CD8+ T-cell epitopes within the surface glycoprotein of a neurotropic coronavirus and correlation with pathogenicity.
    J Virol. 1995 Dec;69(12):8127-31 PMID: 7494335
  33. Involvement of B-1 cells in mucosal immunity and autoimmunity.
    Immunol Today. 1995 Nov;16(11):534-9 PMID: 7495491
  34. Ascitic disease in nude mice infected with mouse hepatitis virus.
    Nihon Juigaku Zasshi. 1985 Feb;47(1):171-4 PMID: 2984447
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.72.11.9286-9290.1998
Email
kyuwa@gpo.kumamoto-u.ac.jp
Published
1998-11-00
Pages
9286-90
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC110348
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.72.11.9286-9290.1998 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2