Home LiteratureArticle Details
PMID: 1662041 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

The role of gamma interferon in infection of susceptible mice with murine coronavirus, MHV-JHM.

Archives of virology ·Vol. 121 ·No. 1-4 ·1991-00-00 ·Pages 89-100

Smith AL, Barthold SW, de Souza MS, Bottomly K

Abstract

Infection of BALB/c mice with mouse hepatitis virus, strain JHM (MHV-JHM), at any of several intervals relative to ovalbumin (OVA) administration resulted in elevated OVA-specific IgG 2 a titers. Since gamma interferon (IFN) has been implicated as an up-regulator of IgG 2 a production, attempts were made to determine whether levels of this cytokine were modified in sera of infected mice. Serum IFN-gamma was not detected, but treatment of MHV-JHM-infected mice with monoclonal anti-IFN-gamma antibody resulted in high mortality with decreased survival times, enhanced virus titers in liver and spleen, and more severe virus-associated pathology, compared to mock-treated, infected mice. Immunotherapy with recombinant IFN-gamma ameliorated disease as reflected by mortality rates and virus titers in target organs.

MeSH Terms
Animals Antibodies, Monoclonal/administration & dosage Antibodies, Viral/immunology Disease Susceptibility Female Hepatitis, Viral, Animal/immunology,microbiology,therapy Interferon-gamma/immunology,physiology,therapeutic use Mice Mice, Inbred BALB C Murine hepatitis virus/immunology,physiology Ovalbumin/administration & dosage Recombinant Proteins Virus Replication
Chemicals
Antibodies, Monoclonal Antibodies, Viral Recombinant Proteins Interferon-gamma Ovalbumin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Smith A L
Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut.
Barthold S W
de Souza M S
Bottomly K
References (31)
31 references, click to expand
  1. Enhanced virus replication and inhibition of lymphocytic choriomeningitis virus disease in anti-gamma interferon-treated mice.
    J Virol. 1989 Jun;63(6):2813-9 PMID: 2542591
  2. Cytotoxic T lymphocyte control of acute lymphocytic choriomeningitis virus infection: interferon gamma, but not tumour necrosis factor alpha, displays antiviral activity in vivo.
    J Gen Virol. 1989 Dec;70 ( Pt 12):3317-25 PMID: 2514255
  3. Diagnosis of murine infections in relation to test methods employed.
    Lab Anim Sci. 1986 Jun;36(3):271-6 PMID: 3014210
  4. Prevalence of natural virus infections in laboratory mice and rats used in Canada.
    Lab Anim Sci. 1986 Apr;36(2):145-8 PMID: 3084866
  5. In vitro splenic T cell responses of diverse mouse genotypes after oronasal exposure to mouse hepatitis virus, strain JHM.
    Lab Anim Sci. 1991 Apr;41(2):106-11 PMID: 1658436
  6. IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses.
    J Immunol. 1988 Feb 15;140(4):1022-7 PMID: 3125247
  7. Altered splenic T cell function of BALB/cByJ mice infected with mouse hepatitis virus or Sendai virus.
    J Immunol. 1987 May 15;138(10):3426-30 PMID: 2437194
  8. Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production.
    Science. 1987 May 22;236(4804):944-7 PMID: 3107127
  9. Delayed increase in plasma lactic dehydrogenase activity in mouse hepatitis virus-infected mice subsequently infected with lactic dehydrogenase virus.
    Lab Anim Sci. 1987 Dec;37(6):792-4 PMID: 2830435
  10. Infection of BALB/cByJ mice with the JHM strain of mouse hepatitis virus alters in vitro splenic T cell proliferation and cytokine production.
    Lab Anim Sci. 1991 Apr;41(2):99-105 PMID: 1658457
  11. Inhibition of B lymphocyte activation by interferon-gamma.
    J Immunol. 1987 Aug 1;139(3):767-73 PMID: 2955050
  12. Alteration of viral respiratory infections of mice by prior infection with mouse hepatitis virus.
    Lab Anim Sci. 1984 Dec;34(6):573-6 PMID: 6097762
  13. A major role of macrophage activation by interferon-gamma during mouse hepatitis virus type 3 infection. I. Genetically dependent resistance.
    Immunobiology. 1989 Nov;180(1):12-22 PMID: 2560461
  14. Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.
    J Exp Med. 1987 Nov 1;166(5):1229-44 PMID: 2960769
  15. Activation of natural killer cells and induction of interferon after injection of mouse hepatitis virus type 3 in mice.
    Infect Immun. 1982 Mar;35(3):869-73 PMID: 6175579
  16. In vivo polyclonal B-lymphocyte activation elicited by murine viruses.
    J Virol. 1990 Nov;64(11):5383-8 PMID: 1976818
  17. Production of B cell stimulatory factor-2 and interferon gamma in the central nervous system during viral meningitis and encephalitis. Evaluation in a murine model infection and in patients.
    J Exp Med. 1988 Jul 1;168(1):449-53 PMID: 3135367
  18. Persistent mouse hepatitis virus infection in nude mice.
    Jpn J Exp Med. 1988 Jun;58(3):115-21 PMID: 3054205
  19. IgG2a restriction of murine antibodies elicited by viral infections.
    J Exp Med. 1987 Jan 1;165(1):64-9 PMID: 3794607
  20. The polyclonal and antigen-specific IgE and IgG subclass response of mice injected with ovalbumin in alum or complete Freund's adjuvant.
    Cell Immunol. 1989 Oct 1;123(1):1-8 PMID: 2776217
  21. Antigenic characterization of Tettnang virus: complications caused by passage of the virus in mice from a colony enzootically infected with mouse hepatitis virus.
    Am J Trop Med Hyg. 1983 Sep;32(5):1172-6 PMID: 6312821
  22. Response of genetically susceptible and resistant mice to intranasal inoculation with mouse hepatitis virus JHM.
    Virus Res. 1987 May;7(3):225-39 PMID: 3037819
  23. Mouse hepatitis virus nasoencephalopathy is dependent upon virus strain and host genotype.
    Arch Virol. 1986;91(3-4):247-56 PMID: 3022679
  24. The role of circulating interferon in the modifications of immune responsiveness by mouse hepatitis virus (MHV-3).
    J Immunol. 1976 Sep;117(3):748-53 PMID: 182881
  25. Interferon gamma is involved in the recovery of athymic nude mice from recombinant vaccinia virus/interleukin 2 infection.
    J Exp Med. 1990 Nov 1;172(5):1495-503 PMID: 2121889
  26. An immunofluorescence test for detection of serum antibody to rodent coronaviruses.
    Lab Anim Sci. 1983 Apr;33(2):157-60 PMID: 6304421
  27. Persistent infection with mouse hepatitis virus of low virulence in nude mice.
    Microbiol Immunol. 1977;21(12):683-91 PMID: 205762
  28. Effect of inapparent murine hepatitis virus infections on macrophages and host resistance.
    J Leukoc Biol. 1986 May;39(5):559-65 PMID: 3009672
  29. Virally induced modulation of murine IgG antibody subclasses.
    J Exp Med. 1988 Dec 1;168(6):2373-8 PMID: 3199074
  30. Responses of mice susceptible or resistant to lethal infection with mouse hepatitis virus, strain JHM, after exposure by a natural route.
    Lab Anim Sci. 1985 Oct;35(5):469-72 PMID: 2414512
  31. IFN-gamma stimulates IgG2a secretion by murine B cells stimulated with bacterial lipopolysaccharide.
    J Immunol. 1988 Apr 1;140(7):2121-7 PMID: 3127461
Article Info
Journal
Archives of virology
Abbr.
Arch Virol
ISSN
0304-8608
DOI
10.1007/BF01316746
Published
1991-00-00
Pages
89-100
Language
English
Region
Austria
NLM ID
7506870
PMCID
PMC7086809
Subset
IM
Grants
NCRR NIH HHS · RR02039 · United States
NCRR NIH HHS · RR04507 · United States
External Links
PubMed source DOI: 10.1007/BF01316746 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2