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PMID: 2166833 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Effective clearance of mouse hepatitis virus from the central nervous system requires both CD4+ and CD8+ T cells.

Journal of virology ·Vol. 64 ·No. 9 ·1990-09-00 ·Pages 4589-92

Williamson JS, Stohlman SA

Abstract

Both CD4+ and CD8+ T cells are required for the clearance of virus from the central nervous system following infection with the JHM strain of mouse hepatitis virus. Development of antiviral antibodies requires the presence of CD4+ T cells but appears to play a minimal role in the reduction of virus. The data presented are consistent with the hypothesis that clearance of JHM virus is mediated by virus-specific CD8+ T cells, which appear to require the presence of CD4+ T cells.

MeSH Terms
Animals Antibodies, Viral/analysis Antigens, Differentiation, T-Lymphocyte/immunology CD4 Antigens/immunology CD8 Antigens Central Nervous System/microbiology Flow Cytometry Hepatitis, Viral, Animal/immunology,microbiology Immunity, Cellular Immunosuppression Therapy Lymphocyte Depletion Mice Mice, Inbred Strains Murine hepatitis virus/immunology,physiology T-Lymphocytes/immunology Virus Replication
Chemicals
Antibodies, Viral Antigens, Differentiation, T-Lymphocyte CD4 Antigens CD8 Antigens
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Williamson J S
Department of Neurology, University of Southern California School of Medicine, Los Angeles 90033.
Stohlman S A
References (17)
17 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.64.9.4589-4592.1990
Published
1990-09-00
Pages
4589-92
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC247935
Subset
IM
Grants
NINDS NIH HHS · NS18146 · United States
External Links
PubMed source DOI: 10.1128/JVI.64.9.4589-4592.1990 PMC Full Text View journal details
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