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PMID: 11381102 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Phi29 family of phages.

Microbiology and molecular biology reviews : MMBR ·Vol. 65 ·No. 2 ·2001-06-00 ·Pages 261-87 ; second page, table of contents

Meijer WJ, Horcajadas JA, Salas M

Abstract

Continuous research spanning more than three decades has made the Bacillus bacteriophage phi29 a paradigm for several molecular mechanisms of general biological processes, such as DNA replication, regulation of transcription, phage morphogenesis, and phage DNA packaging. The genome of bacteriophage phi29 consists of a linear double-stranded DNA (dsDNA), which has a terminal protein (TP) covalently linked to its 5' ends. Initiation of DNA replication, carried out by a protein-primed mechanism, has been studied in detail and is considered to be a model system for the protein-primed DNA replication that is also used by most other linear genomes with a TP linked to their DNA ends, such as other phages, linear plasmids, and adenoviruses. In addition to a continuing progress in unraveling the initiation of DNA replication mechanism and the role of various proteins involved in this process, major advances have been made during the last few years, especially in our understanding of transcription regulation, the head-tail connector protein, and DNA packaging. Recent progress in all these topics is reviewed. In addition to phi29, the genomes of several other Bacillus phages consist of a linear dsDNA with a TP molecule attached to their 5' ends. These phi29-like phages can be divided into three groups. The first group includes, in addition to phi29, phages PZA, phi15, and BS32. The second group comprises B103, Nf, and M2Y, and the third group contains GA-1 as its sole member. Whereas the DNA sequences of the complete genomes of phi29 (group I) and B103 (group II) are known, only parts of the genome of GA-1 (group III) were sequenced. We have determined the complete DNA sequence of the GA-1 genome, which allowed analysis of differences and homologies between the three groups of phi29-like phages, which is included in this review.

MeSH Terms
Amino Acid Sequence Bacillus/metabolism,virology Bacillus Phages/chemistry,genetics,growth & development Base Sequence DNA Replication DNA, Viral/metabolism Molecular Sequence Data RNA, Viral/metabolism Transcription, Genetic Viral Proteins/chemistry,genetics
Chemicals
DNA, Viral RNA, Viral Viral Proteins phage phi29 protein p6
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Meijer W J
Centro de Biología Molecular Severo Ochoa, Universidad Autónoma, Canto Blanco, 28049 Madrid, Spain.
Horcajadas J A
Salas M
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Article Info
Journal
Microbiology and molecular biology reviews : MMBR
Abbr.
Microbiol Mol Biol Rev
ISSN
1092-2172
DOI
10.1128/MMBR.65.2.261-287.2001
Published
2001-06-00
Pages
261-87 ; second page, table of contents
Language
English
Region
United States
NLM ID
9706653
PMCID
PMC99027
Subset
IM
Grants
NIGMS NIH HHS · R01 GM027242 · United States
NIGMS NIH HHS · 2R01 GM27242-21 · United States
External Links
PubMed source DOI: 10.1128/MMBR.65.2.261-287.2001 PMC Full Text View journal details
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