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PMID: 10707065 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Phages will out: strategies of host cell lysis.

Trends in microbiology ·Vol. 8 ·No. 3 ·2000-03-00 ·Pages 120-8

Young I, Wang I, Roof WD

Abstract

Most phages accomplish host lysis using a muralytic enzyme, or endolysin, and a holin, which permeabilizes the membrane at a programmed time and thus controls the length of the vegetative cycle. By contrast, lytic single-stranded RNA and DNA phages accomplish lysis by producing a single lysis protein without muralytic activity.

MeSH Terms

Amino Acid Sequence Bacteriophages/metabolism,pathogenicity Cell Membrane Permeability Endopeptidases/metabolism Gram-Negative Bacteria/virology Membrane Proteins/metabolism Molecular Sequence Data Sequence Homology, Amino Acid Viral Proteins/genetics,metabolism

Chemicals

Membrane Proteins S holin, bacteriophage lambda Viral Proteins Rz protein, bacteriophage lambda Endopeptidases endolysin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Young I

Dept of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843-2128, USA. ryland@tamu.edu

Wang I

Roof W D

Article Info

Journal

Trends in microbiology

Abbr.

Trends Microbiol

ISSN

0966-842X

DOI

10.1016/s0966-842x(00)01705-4

ryland@tamu.edu

Published

2000-03-00

Pages

120-8

Language

English

Region

England

NLM ID

9310916

Subset

Grants

NIGMS NIH HHS · R01 GM027099 · United States

NIGMS NIH HHS · GM27099 · United States

External Links

PubMed source DOI: 10.1016/s0966-842x(00)01705-4 View journal details

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