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PMID: 283391 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Symmetry mismatch and DNA packaging in large bacteriophages.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 75 ·No. 10 ·1978-10-00 ·Pages 4779-83

Hendrix RW

Abstract

A model is presented for the mechanism of packaging double-stranded DNA into phage heads. The model is based on, and rationalizes, the mismatch in symmetry between the heads and tails of large bacteriophages. DNA movement is postulated to be mediated by a rotating protein structure at the tail-proximal vertex of the head.

MeSH Terms
Bacteriophages/genetics,ultrastructure DNA, Viral Models, Biological Morphogenesis Viral Proteins
Chemicals
DNA, Viral Viral Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hendrix R W
References (45)
45 references, click to expand
  1. Buoyant density sedimentation of macromolecules in sodium iothalamate density gradients.
    J Mol Biol. 1975 Mar 5;92(3):433-48 PMID: 167175
  2. DNA packaging and the pathway of bacteriophage T4 head assembly.
    Proc Natl Acad Sci U S A. 1977 Sep;74(9):3652-6 PMID: 269421
  3. DNA arrangement in isometric phage heads.
    Nature. 1977 Aug 18;268(5621):598-602 PMID: 401433
  4. Studies on the structure, protein composition and aseembly of the neck of bacteriophage T4.
    J Mol Biol. 1977 Nov 5;116(3):375-405 PMID: 592389
  5. Recalibrated linkage map of Escherichia coli K-12.
    Bacteriol Rev. 1976 Mar;40(1):116-67 PMID: 773363
  6. Morphogenesis of bacteriophage lambda: electron microscopy of thin sections.
    J Mol Biol. 1976 May 15;103(2):299-318 PMID: 781268
  7. Assembly of the head of bacteriophage P22: x-ray diffraction from heads, proheads and related structures.
    J Mol Biol. 1976 Jun 25;104(2):387-410 PMID: 781287
  8. Lambda head morphogenesis as seen in the electron microscope.
    Virology. 1976 Jul 15;72(2):429-42 PMID: 782021
  9. Internal proteins of bacteriophage T7.
    J Mol Biol. 1976 Nov 5;107(3):271-91 PMID: 794484
  10. Analysis of gene function of bacteriophage phi 29 of Bacillus subtilis: identification of cistrons essential for viral assembly.
    J Virol. 1976 Aug;19(2):501-17 PMID: 822175
  11. Studies on an in vitro system for the packaging and maturation of phage lambda DNA.
    Virology. 1977 May 1;78(1):277-90 PMID: 860404
  12. Early events in the in vitro packaging of bacteriophage lambda DNA.
    Virology. 1977 May 1;78(1):291-305 PMID: 860405
  13. Morphogenetic core of the bacteriophage T4 head. Structure of the core in polyheads.
    J Mol Biol. 1977 Apr 25;111(4):459-85 PMID: 864705
  14. Localization of minor protein components of the head of bacteriophage T4.
    J Virol. 1977 Oct;24(1):121-34 PMID: 904022
  15. Structural analysis of macromolecular assemblies by image reconstruction from electron micrographs.
    Annu Rev Biochem. 1975;44:161-82 PMID: 1094909
  16. Virus assembly.
    Annu Rev Biochem. 1975;44:555-611 PMID: 1094918
  17. DNA packaging steps in bacteriophage lambda head assembly.
    J Mol Biol. 1975 Jan 15;91(2):175-86 PMID: 1102700
  18. Assembly of bacteriophage lambda heads: protein processing and its genetic control in petit lambda assembly.
    J Mol Biol. 1975 Jan 15;91(2):187-99 PMID: 1102701
  19. Petit lambda, a family of particles from coliphage lambda infected cells.
    J Mol Biol. 1975 Oct 15;98(1):107-20 PMID: 1104865
  20. Dissociation by chelating agents and substructure of the thermophilic bacteriophage TP84.
    J Virol. 1971 May;7(5):663-72 PMID: 4104254
  21. Electron microscope observations on lambda bacteriophage ultrastructure.
    J Ultrastruct Res. 1973 Nov;45(3):259-78 PMID: 4128211
  22. The lambda head-tail joining reaction: purification, properties and structure of biologically active heads and tails.
    J Mol Biol. 1973 Sep 25;79(3):437-49 PMID: 4202216
  23. Connection of the right-hand terminus of DNA to the proximal end of the tail in bacteriophage lambda.
    Virology. 1974 Oct;61(2):524-36 PMID: 4419247
  24. Phage lambda DNA packaging, in vitro.
    J Supramol Struct. 1974;2(2-4):302-17 PMID: 4437178
  25. Locations and amounts of major structural proteins in bacteriophage lambda.
    J Mol Biol. 1974 Sep 15;88(2):535-45 PMID: 4476800
  26. In vitro assembly of bacteriophage Lambda heads.
    Proc Natl Acad Sci U S A. 1973 Jan;70(1):260-4 PMID: 4509659
  27. In vitro packaging of satellite phage P4 DNA.
    Proc Natl Acad Sci U S A. 1974 Jun;71(6):2367-71 PMID: 4526304
  28. Packaging and maturation of DNA of bacteriophage T7 in vitro.
    Proc Natl Acad Sci U S A. 1974 Sep;71(9):3545-9 PMID: 4530321
  29. Arrangement of DNA in lambda bacteriophage heads. 3. Location and number of nucleotides cleaved from lambda-DNA by micrococcal nuclease attack on heads.
    J Mol Biol. 1972 Aug 21;69(2):201-7 PMID: 4560947
  30. A DNA-binding form of the main structural protein of lambda heads.
    Virology. 1973 Aug;54(2):441-51 PMID: 4579885
  31. Bacteria swim by rotating their flagellar filaments.
    Nature. 1973 Oct 19;245(5425):380-2 PMID: 4593496
  32. Flagellar rotation and the mechanism of bacterial motility.
    Nature. 1974 May 3;249(452):73-4 PMID: 4598030
  33. Activity of empty, headlike particles for packaging of DNA of bacteriophage lambda in vitro.
    Proc Natl Acad Sci U S A. 1974 Jun;71(6):2372-6 PMID: 4601587
  34. Chemical linkage of the tail to the right-hand end of bacteriophage lambda DNA.
    J Mol Biol. 1974 Jul 25;87(1):1-9 PMID: 4610148
  35. Location of DNA ends in P2, 186, P4 and lambda bacteriophage heads.
    J Mol Biol. 1974 Jul 25;87(1):11-22 PMID: 4610150
  36. P22 morphogenesis. I: Catalytic scaffolding protein in capsid assembly.
    J Supramol Struct. 1974;2(2-4):202-24 PMID: 4612247
  37. Maturation of the head of bacteriophage T4. V. A possible DNA packaging mechanism: in vitro cleavage of the head proteins and the structure of the core of the polyhead.
    J Supramol Struct. 1974;2(2-4):276-301 PMID: 4612250
  38. DNA synthesis during the division cycle of rapidly growing Escherichia coli B/r.
    J Mol Biol. 1968 Feb 14;31(3):507-18 PMID: 4866336
  39. RNA chain growth rates in Escherichia coli.
    J Mol Biol. 1969 Jan 14;39(1):1-29 PMID: 4938814
  40. Structure of Bacillus subtilis bacteriophage phi 29 and the length of phi 29 deoxyribonucleic acid.
    J Bacteriol. 1966 May;91(5):2081-9 PMID: 4957028
  41. Determination of gene product positions in bacteriophage T4 by specific antibody association.
    J Mol Biol. 1970 Jul 28;51(2):411-21 PMID: 5530395
  42. Disruption of T-even bacteriophages by dimethyl sulfoxide.
    J Virol. 1968 Jun;2(6):610-20 PMID: 5697471
  43. The shape of the T-even bacteriophage head.
    Virology. 1965 Aug;26(4):567-76 PMID: 5833315
  44. Physical principles in the construction of regular viruses.
    Cold Spring Harb Symp Quant Biol. 1962;27:1-24 PMID: 14019094
  45. Chromosome structure in phage t4, iii. Terminal redundancy and length determination.
    Proc Natl Acad Sci U S A. 1967 Feb;57(2):292-5 PMID: 16591467
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.75.10.4779
Published
1978-10-00
Pages
4779-83
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC336203
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.75.10.4779 PMC Full Text View journal details
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