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PMID: 1092540 Published · ppublish English Journal Article Review

Platelets, thrombosis and drugs.

Drugs ·Vol. 9 ·No. 1 ·1975-00-00 ·Pages 19-76

Mustard JF, Packham MA

Abstract

The development of thrombosis involves 4 main factors: the vessel wall, the formed elements of the blood, blood coagulation, and blood flow. In venous thrombosis, however, the major part in both the initiation and growth of thrombi is played by the platelets. In selecting drugs which inhibit platelet function it is helful to know which of the platelet reactions that contribute to thrombus formation can be inhibited by various agents. Platelets adhere to the damaged vessel wall, collagen being probably the most important constituent involved. They are then stimulated to release the contents of their storage granules. Release-inducing agents promote the discharge of adenosine diphosphate (ADP) which causes platelets in the vicinity to swell to a more spherical shape, extend pseudopods and adhere to each other. Platelet aggregation is reversible, and a number of drugs have been shown to be capable of inhibiting platelet function at various stages, both in vitro and in vivo. Adrenaline, noradrenaline, oestrogens and nicotine enhance aggregation. Drugs which inhibit platelet function include the non-steroidal anti-inflammatory drugs, the pyrimido-pyrimidines (e.g. dipyridamole), hydroxychloroquine, clofibrate, and dextran. In this review the effects of drugs which inhibit platelet function are outlined and the extent to which they can be used to influence the course of thromboembolic disease in man is discussed. It is suggested that combination of anti-platelet drugs with anticoagulants could prove clinically useful.

MeSH Terms
Blood Coagulation/drug effects Blood Platelets/drug effects,physiology Clofibrate/pharmacology Depression, Chemical Dextrans/pharmacology Fibrinolytic Agents/pharmacology Heparin/pharmacology Humans In Vitro Techniques Platelet Aggregation/drug effects Prostaglandins/pharmacology Thrombosis/physiopathology,prevention & control
Chemicals
Dextrans Fibrinolytic Agents Prostaglandins Heparin Clofibrate
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Mustard J F
Packham M A
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Article Info
Journal
Drugs
Abbr.
Drugs
ISSN
0012-6667
DOI
10.2165/00003495-197509010-00003
Published
1975-00-00
Pages
19-76
Language
English
Region
New Zealand
NLM ID
7600076
Subset
IM
External Links
PubMed source DOI: 10.2165/00003495-197509010-00003 View journal details
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