Home LiteratureArticle Details
PMID: 5046478 Published · ppublish English Clinical Trial Controlled Clinical Trial Journal Article

Modification by drugs of urinary fibrin/fibrinogen degradation products in glomerulonephritis.

British medical journal ·Vol. 3 ·No. 5821 ·1972-07-29 ·Pages 255-60

Clarkson AR, MacDonald MK, Cash JD, Robson JS

Abstract

Treatment with indomethacin, aspirin, or prednisone has been shown to reduce urinary fibrin/fibrinogen degradation products (F.D.P.) in approximately two-thirds of patients with proliferative glomerulonephritis. This reduction which is dose-dependent for prednisone but not for indomethacin or aspirin in the range of doses used occurs within two to three days of beginning treatment and is thought to result from decreased intraglomerular fibrin deposition rather than alteration of glomerular permeability to F.D.P. In patients who responded in this manner treatment was associated with reductions in the degree of proteinuria and maintenance or improvement in renal function.

MeSH Terms
Adolescent Adult Aged Aspirin/therapeutic use Child Creatinine/metabolism Female Fibrin/metabolism,urine Fibrinogen/metabolism,urine Glomerulonephritis/drug therapy,metabolism,urine Humans Indomethacin/therapeutic use Kidney Glomerulus/metabolism Male Middle Aged Plasminogen/blood Prednisone/therapeutic use Proteinuria/drug therapy Time Factors Urea/blood
Chemicals
Urea Fibrin Fibrinogen Plasminogen Creatinine Aspirin Prednisone Indomethacin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Clarkson A R
MacDonald M K
Cash J D
Robson J S
References (23)
23 references, click to expand
  1. Quantitative estimation of split products of fibrinogen in human serum, relation to diagnosis and treatment.
    Blood. 1966 Jul;28(1):1-18 PMID: 5944259
  2. The fibrinolytic response to moderate exercise and intravenous adrenaline in the same subjects.
    Br J Haematol. 1967 May;13(3):376-83 PMID: 6025247
  3. Fibrinogen and fibrin degradation products and the clumping of staphylococci by serum.
    Br J Haematol. 1967 Jul;13(4):550-67 PMID: 6029955
  4. Staphylococcal clumping with soluble fibrin mmonomer complexes.
    J Exp Med. 1967 Nov 1;126(5):979-88 PMID: 4228857
  5. Suppressive effects of indomethacin on crystal-induced inflammation in canine joints and on neutrophilic motility in vitro.
    J Pharmacol Exp Ther. 1967 Dec;158(3):546-53 PMID: 6073234
  6. Further studies on the erythrocyte anti-inflammatory assay.
    Proc Soc Exp Biol Med. 1968 Jun;128(2):504-9 PMID: 5663264
  7. [Histological course of diffuse proliferative glomerulonephritis treated with indomethacin].
    J Urol Nephrol (Paris). 1969 Apr-May;75(4):315-8 PMID: 5370830
  8. Investigations and preparation of fibrinogencoated tan A/Das PC: Investigations and preparation of fibrinogen-coated tanned sheep red cells.
    J Clin Pathol. 1970 Mar;23(2):149-55 PMID: 5463737
  9. Effect of acetylsalicylic acid, other nonsteroidal anti-inflammatory agents, and dipyridamole on human blood platelets.
    J Lab Clin Med. 1970 Jul;76(1):66-75 PMID: 5425364
  10. Effect of prednisolone on the coagulation and fibrinolytic systems.
    Scand J Haematol. 1970;7(3):212-6 PMID: 5447966
  11. Controlled trial of prednisone in adult patients with the nephrotic syndrome.
    Br Med J. 1970 Aug 22;3(5720):421-6 PMID: 4916790
  12. A comparative study of four methods for detecting fibrinogen degradation products in patients with various diseases.
    N Engl J Med. 1970 Sep 24;283(13):663-8 PMID: 4247823
  13. A comparison of an effect of different anti-inflammatory drugs on human platelets.
    J Clin Pathol. 1970 Sep;23(6):522-5 PMID: 5476879
  14. Urinary fibrin-fibrinogen degradation poducts after renal homotransplantation.
    Lancet. 1970 Dec 12;2(7685):1220-3 PMID: 4098659
  15. Indomethacin and urinary excretion of fibrinogen-like material in proliferative glomerulonephritis.
    Rev Eur Etud Clin Biol. 1970 Nov;15(9):979-84 PMID: 5505090
  16. Mechanism of the inhibitory action of indomethacin on smooth muscle.
    Br J Pharmacol. 1971 Mar;41(3):540-51 PMID: 4396972
  17. Assay for fibrinolytic split products: comparison of staphylococcal clumping and hemagglutination-inhibition tests.
    J Lab Clin Med. 1971 Jun;77(6):993-9 PMID: 5559865
  18. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.
    Nat New Biol. 1971 Jun 23;231(25):232-5 PMID: 5284360
  19. Aspirin selectively inhibits prostaglandin production in human platelets.
    Nat New Biol. 1971 Jun 23;231(25):235-7 PMID: 5284361
  20. Serum and urinary fibrin-fibrinogen degradation products in glomerulonephritis.
    Br Med J. 1971 Aug;3(5772):447-51 PMID: 5567767
  21. Detection of serum fibrinogen and fibrin degradation products. Comparison of six technics using purified products and application in clinical studies.
    Am J Med. 1971 Jul;51(1):71-82 PMID: 4998883
  22. Influence of acetylsalicylic acid, butazolidine, colchicine, hydrocortisone, chlorpromazine and imipramine on the phagocytosis of polystyrene latex particles by human leucocytes.
    Biochem Pharmacol. 1971 Jan;20(1):119-24 PMID: 5570631
  23. Effect of large doses of prednisone on the renal lesions and life span of patients with lupus glomerulonephritis.
    J Lab Clin Med. 1961 Apr;57:495-511 PMID: 13736844
Article Info
Journal
British medical journal
Abbr.
Br Med J
ISSN
0007-1447
DOI
10.1136/bmj.3.5821.255
Published
1972-07-29
Pages
255-60
Language
English
Region
England
NLM ID
0372673
PMCID
PMC1785719
Subset
IM
External Links
PubMed source DOI: 10.1136/bmj.3.5821.255 PMC Full Text
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2