Action of a pyrimido-pyrimidine compound on platelet behaviour in vitro.

British medical journal ·Vol. 2 ·No. 5655 ·1969-05-24 ·Pages 483-5

Forbes CD, McNicol GP, Douglas AS

Abstract

A pyrimido-pyrimidine compound (RA433) was found in vitro to be a significantly more potent inhibitor of platelet behaviour than the previously available pyrimido-pyrimidine compound RA8-dipyridamole. In a turbidimetric system RA433 inhibits platelet aggregation induced by adenosine diphosphate, collagen, and noradrenaline; further, in a glass-bead-column technique it is a powerful inhiitor of platelet adhesiveness.

MeSH Terms

Adenine Nucleotides Blood Coagulation/drug effects Blood Platelets/drug effects Collagen Depression, Chemical Dipyridamole/pharmacology Humans In Vitro Techniques Morpholines/pharmacology Norepinephrine Pyrimidines/pharmacology

Chemicals

Adenine Nucleotides Morpholines Pyrimidines Dipyridamole Collagen Norepinephrine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Forbes C D

McNicol G P

Douglas A S

References (17)

17 references, click to expand

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Article Info

Journal

British medical journal

Abbr.

Br Med J

ISSN

0007-1447

DOI

10.1136/bmj.2.5655.483

Published

1969-05-24

Pages

483-5

Language

English

Region

England

NLM ID

0372673

PMCID

PMC1983431

Subset

External Links

PubMed source DOI: 10.1136/bmj.2.5655.483 PMC Full Text

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Action of a pyrimido-pyrimidine compound on platelet behaviour in vitro.

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