Heterophile antibodies and tissue injury. 3. A role for platelets in the development of lethal vascular injury during Forssman shock in guinea pigs.

The American journal of pathology ·Vol. 72 ·No. 2 ·1973-08-00 ·Pages 179-200

Tsai CC, Taichman NS, Pulver WH, Schönbaum E

Abstract

Platelets appear to be pathogenetic determinants in the development of lethal Forssman shock, which was provoked in guinea pigs by an intravenous injection of rabbit antiserum to sheep erythrocyte stromata. Within moments, circulating platelets (prelabeled with (14)C-serotonin) were removed from the blood stream and impacted in the lungs, where they liberated (14)C into the tissues. When animals were depleted of platelets prior to the production of shock, they survived for prolonged periods of time or were protected against death. Pretreatment with antiinflammatory compounds capable of inhibiting platelet aggregation and release phenomena had a similar protective influence. It would appear, therefore, that Forssman shock is a convenient and accessible model for investigating the mechanisms whereby platelets mediate immune vascular damage.

MeSH Terms

Anaphylaxis/immunology,prevention & control Animals Antibodies, Heterophile Aspirin/pharmacology Blood Cell Count Blood Platelet Disorders/pathology Blood Platelets/immunology Blood Vessels/pathology Capillaries/pathology Carbon Isotopes Complement System Proteins/analysis Forssman Antigen Guinea Pigs Immune Sera Leukocytes/immunology Liver/immunology Lung/blood supply,immunology Microscopy, Electron Mortality Rabbits/immunology Serotonin Sheep/immunology Spleen/immunology Sulfinpyrazone/pharmacology Time Factors

Chemicals

Antibodies, Heterophile Carbon Isotopes Immune Sera Serotonin Complement System Proteins Forssman Antigen Aspirin Sulfinpyrazone

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Tsai C C

Taichman N S

Pulver W H

Schönbaum E

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26 references, click to expand

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Article Info

Journal

The American journal of pathology

Abbr.

Am J Pathol

ISSN

0002-9440

Published

1973-08-00

Pages

179-200

Language

English

Region

United States

NLM ID

0370502

PMCID

PMC1903990

Subset

External Links

PubMed source PMC Full Text View journal details

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Heterophile antibodies and tissue injury. 3. A role for platelets in the development of lethal vascular injury during Forssman shock in guinea pigs.

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