The role of the platelet in the generalized Shwartzman reaction.

The Journal of experimental medicine ·Vol. 129 ·No. 3 ·1969-03-01 ·Pages 585-90

Margaretten W, McKay DG

Abstract

Rabbits were injected with an antiplatelet serum to produce selective thrombocytopenia without inducing a significant alteration of their leukocyte counts. Thrombocytopenic levels persisted for 8 hr after the injection of platelet antiserum. During this time, the generalized Shwartzman reaction could not be provoked with the second injection of endotoxin. Since platelet phospholipid is required for the formation of plasma thromboplastin, the results indicate that platelets are essential to the evolution of the generalized Shwartzman reaction and endotoxin triggers the intrinsic rather than the extrinsic clotting system to elicit the lesions.

MeSH Terms

Animals Blood Cell Count Blood Platelets/immunology,physiopathology Endotoxins Escherichia coli/analysis Female Heparin/pharmacology Immune Sera Injections, Intravenous Leukocyte Count Lipopolysaccharides Polysaccharides, Bacterial Rabbits Shwartzman Phenomenon/etiology,physiopathology Thrombocytopenia/etiology

Chemicals

Endotoxins Immune Sera Lipopolysaccharides Polysaccharides, Bacterial Heparin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Margaretten W

McKay D G

References (9)

9 references, click to expand

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Antigen-antibody reaction in the pathogenesis of bilateral renal cortical necrosis.
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Effects of bacterial endotoxin on rabbit platelets. II. Enhancement of platelet factor 3 activity in vitro and in vivo.
J Exp Med. 1962 Nov 1;116:619-33 PMID: 13954979
Studies on the generalized Shwartzman reaction: I. General observations concerning the phenomenon.
J Exp Med. 1952 Dec;96(6):605-24 PMID: 13022854
Intravascular activation of the clotting system with phospholipids. Production of the generalized Shwartzman reaction with platelet factor 3.
Blood. 1965 Nov;26(5):541-53 PMID: 5845780
Morphology and enumeration of human blood platelets.
J Appl Physiol. 1950 Dec;3(6):365-77 PMID: 14794596
Platelet factor 3 and the generalized Shwartzman reaction.
Thromb Diath Haemorrh. 1967 Dec 31;18(3-4):726-35 PMID: 5627414
Alterations in the blood coagulation system induced by bacterial endotoxin. I. In vivo (generalized Shwartzman reaction).
J Exp Med. 1958 Mar 1;107(3):353-67 PMID: 13513905

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.129.3.585

Published

1969-03-01

Pages

585-90

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2138615

Subset

External Links

PubMed source DOI: 10.1084/jem.129.3.585 PMC Full Text View journal details

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The role of the platelet in the generalized Shwartzman reaction.

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