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PMID: 14264269 Published · ppublish English Journal Article

PLATELETS AND THE SHWARTZMAN PHENOMENON.

The Journal of experimental medicine ·Vol. 121 ·1965-02-01 ·Pages 235-46

LEVIN J, CLUFF LE

Abstract

Studies are reported on the effect of immunologically induced thrombocytopenia upon the local and generalized Shwartzman phenomena. Intravenous injection of antiplatelet serum to rabbits produced profound but transient thrombocytopenia unaccompanied by significant changes in circulating leucocytes. Platelet antiserum alone given to rabbits prepared with thorotrast produced renal lesions characteristic of the Shwartzman reaction. Thrombocytopenia induced by platelet antiserum did not inhibit the cutaneous hemorrhagic lesion of the local Shwartzman phenomenon produced by sequential injections of endotoxin intracutaneously and intravenously. The implications of these observations in the pathogenesis of the local cutaneous and generalized Shwartzman reaction are discussed.

Keywords
AMINOSALICYLIC ACID BLOOD PLATELETS ENDOTOXINS EXPERIMENTAL LAB STUDY IMMUNE SERUMS LEUKOCYTE COUNT RABBITS SHWARTZMAN PHENOMENON THORIUM DIOXIDE THROMBOPENIA TOXICOLOGIC REPORT
MeSH Terms
Aminosalicylic Acid Aminosalicylic Acids Animals Blood Platelets Endotoxins Immune Sera Kidney Leukocyte Count Leukocytes Rabbits Research Shwartzman Phenomenon Thorium Dioxide Thrombocytopenia Toxicology
Chemicals
Aminosalicylic Acids Endotoxins Immune Sera Aminosalicylic Acid Thorium Dioxide
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
LEVIN J
CLUFF L E
References (19)
19 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.121.2.235
Published
1965-02-01
Pages
235-46
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2137980
Subset
OM
External Links
PubMed source DOI: 10.1084/jem.121.2.235 PMC Full Text View journal details
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