The requirement for platelets in the active Arthus reaction.

The American journal of pathology ·Vol. 64 ·No. 2 ·1971-08-00 ·Pages 257-70

Margaretten W, McKay DG

Abstract

The active Arthus reaction was completely inhibited in rabbits made thrombocytopenic with platelet antiserum. Platelets or some platelet factor is necessary for the development of immune vasculitis in this model. Since the classic Arthus reaction depends on the union of extravascular antigen with intravascular antibody, it is probable that the missing platelet factor is an agent that alters vascular permeability.

MeSH Terms

Animals Arthus Reaction/pathology,prevention & control Blood Cell Count Blood Platelet Disorders/chemically induced,immunology Blood Platelets/immunology Chemotaxis Complement System Proteins/isolation & purification Female Immune Sera Leukocytes/immunology Male Rabbits Thrombosis/pathology Time Factors

Chemicals

Immune Sera Complement System Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Margaretten W

McKay D G

References (13)

13 references, click to expand

The mechanism of Arthus reactions. II. The role of polymorphonuclear leucocytes and platelets in reversed passive reactions in the guinea-pig.
Br J Exp Pathol. 1955 Jun;36(3):283-9 PMID: 13239984
The localization of circulating immune complexes in experimental serum sickness. The role of vasoactive amines and hydrodynamic forces.
J Exp Med. 1968 Jan 1;127(1):119-36 PMID: 4864670
The role of polymorphonuclear leukocytes in the initiation and cessation of the Arthus vasculitis.
J Exp Med. 1959 Sep 1;110:481-94 PMID: 13810816
Studies of aggregated gamma-globulin. I. Sedimentation, electrophoretic and anticomplementary properties.
J Immunol. 1960 Jan;84:112-6 PMID: 13810121
The role of the platelet in the generalized Shwartzman reaction.
J Exp Med. 1969 Mar 1;129(3):585-90 PMID: 4886043
THE ROLE OF SERUM COMPLEMENT IN CHEMOTAXIS OF LEUKOCYTES IN VITRO.
J Exp Med. 1965 Aug 1;122:327-46 PMID: 14316948
The mechanism of Arthus reactions. I. The role of polymorphonuclear leucocytes and other factors in reversed passive Arthus reactions in rabbits.
Br J Exp Pathol. 1955 Jun;36(3):268-82 PMID: 13239983
BOUND COMPLEMENT AND IMMUNOLOGIC INJURY OF BLOOD VESSELS.
J Exp Med. 1965 Feb 1;121:215-34 PMID: 14264268
The histamine and serotonin content of the platelets and polymorphonuclear leucocytes of various species.
J Physiol. 1954 May 28;124(2):305-10 PMID: 13175133
Ultrastructure of the local Arthus phenomenon using horseradish peroxidase as antigen.
Lab Invest. 1970 Aug;23(2):129-35 PMID: 4247264
Studies of aggregated gamma-globulin. II. Effect in vivo.
J Immunol. 1960 Jan;84:117-21 PMID: 13810122
The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes.
J Exp Med. 1962 Mar 1;115:453-66 PMID: 13872176
Platelet aggregation and release of ADP, serotonin and histamine associated with phagocytosis of antigen-antibody complexes.
Proc Soc Exp Biol Med. 1965 Oct;120(1):232-7 PMID: 4159017

Article Info

Journal

The American journal of pathology

Abbr.

Am J Pathol

ISSN

0002-9440

Published

1971-08-00

Pages

257-70

Language

English

Region

United States

NLM ID

0370502

PMCID

PMC2047577

Subset

External Links

PubMed source PMC Full Text View journal details

Analysis Services

The requirement for platelets in the active Arthus reaction.

Contact

WeChat Official Account