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PMID: 9475350 Published · ppublish English Journal Article Review

Oral tolerance.

Journal of clinical immunology ·Vol. 18 ·No. 1 ·1998-01-00 ·Pages 1-30

Strober W, Kelsall B, Marth T

Abstract

Oral tolerance is the immunologic mechanism by which the mucosal immune system maintains unresponsiveness to the myriad of antigens in the mucosal environment which might otherwise induce untoward immune responses. Recent studies have shown that it is mediated by several distinct, yet interacting mechanisms including the generation of suppressive T cells producing antigen nonspecific cytokines and the induction of clonal deletion and/or anergy. In this review of oral tolerance, we discuss these mechanisms in detail and show how oral tolerance or lack thereof may explain the occurrence of mucosal inflammation. In addition, we discuss how induction of oral tolerance can be used to treat autoimmune states.

MeSH Terms
Humans Immune Tolerance/immunology Immunity, Mucosal/immunology Mouth Mucosa/immunology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Strober W
Mucosal Immunity Section, Laboratory for Clinical Investigation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892-1890, USA.
Kelsall B
Marth T
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Article Info
Journal
Journal of clinical immunology
Abbr.
J Clin Immunol
ISSN
0271-9142
DOI
10.1023/a:1023222003039
Published
1998-01-00
Pages
1-30
Language
English
Region
Netherlands
NLM ID
8102137
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1023222003039 View journal details
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