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PMID: 9151709 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis.

The Journal of experimental medicine ·Vol. 185 ·No. 10 ·1997-05-19 ·Pages 1837-49

Zhang X, Brunner T, Carter L, Dutton RW, Rogers P, Bradley L, Sato T, Reed JC, Green D, Swain SL

Abstract

T helper cell (Th) 1, but not Th2, effectors undergo rapid Fas/Fas ligand (FasL)-mediated, activation-induced cell death upon restimulation with antigen. Unequal apoptosis is also observed without restimulation, after a longer lag period. Both effectors undergo delayed apoptosis induced by a non-Fas-mediated pathway. When Th1 and Th2 effectors are co-cultured, Th2 effectors survive preferentially, suggesting the responsible factor(s) is intrinsic to each population. Both Th1 and Th2 effectors express Fas and FasL, but only Th2 effectors express high levels of FAP-1, a Fas-associated phosphatase that may act to inhibit Fas signaling. The rapid death of Th1 effectors leading to selective Th2 survival provides a novel mechanism for differential regulation of the two subsets.

MeSH Terms
Animals Antigens Apoptosis Carrier Proteins/biosynthesis,physiology Cell Survival Cells, Cultured Coculture Techniques Cytokines/biosynthesis Fas Ligand Protein Kinetics Lymphocyte Activation Membrane Glycoproteins/physiology Mice Mice, Inbred C3H Mice, Transgenic Protein Tyrosine Phosphatase, Non-Receptor Type 13 Protein Tyrosine Phosphatases/biosynthesis,physiology Receptors, Antigen, T-Cell/biosynthesis,physiology Th1 Cells/cytology,immunology,physiology Th2 Cells/cytology,immunology,physiology Time Factors fas Receptor/physiology
Chemicals
Antigens Carrier Proteins Cytokines FASLG protein, human Fas Ligand Protein Fasl protein, mouse Membrane Glycoproteins Receptors, Antigen, T-Cell fas Receptor PTPN13 protein, human Protein Tyrosine Phosphatase, Non-Receptor Type 13 Protein Tyrosine Phosphatases Ptpn13 protein, mouse
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Zhang X
University of California, San Diego, La Jolla, California 92093, USA.
Brunner T
Carter L
Dutton R W
Rogers P
Bradley L
Sato T
Reed J C
Green D
Swain S L
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.185.10.1837
Published
1997-05-19
Pages
1837-49
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2196321
Subset
IM
Grants
NIGMS NIH HHS · GM52735 · United States
NIAID NIH HHS · AI37935 · United States
NIAID NIH HHS · AI26887 · United States
External Links
PubMed source DOI: 10.1084/jem.185.10.1837 PMC Full Text View journal details
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