The immune response of mice to bacterial antigens given by mouth.

Immunology ·Vol. 38 ·No. 3 ·1979-11-00 ·Pages 497-502

Stokes CR, Newby TJ, Huntley JH, Patel D, Bourne FJ

Abstract

The secretory and systemic antibody responses to oral dead Escherichia coli were examined in A strain mice. The best responses were obtained in mice dosed with 1 x 10(10) bacteria. Orally immunized animals showed an enhanced response to subsequent parenteral immunization with somatic antigens. This effect could be passively transferred with serum. In contrast, the response to the capsular antigen K88 was reduced in the same animals.

MeSH Terms

Administration, Oral Animals Antibodies, Bacterial/biosynthesis Antigens, Bacterial/administration & dosage,immunology Escherichia coli/immunology Immunoglobulin A, Secretory/biosynthesis Immunoglobulin G/biosynthesis Injections, Intravenous Intestinal Secretions/immunology Mice Mice, Inbred A Mice, Inbred CBA

Chemicals

Antibodies, Bacterial Antigens, Bacterial Immunoglobulin A, Secretory Immunoglobulin G

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Stokes C R

Newby T J

Huntley J H

Patel D

Bourne F J

References (20)

20 references, click to expand

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Article Info

Journal

Immunology

Abbr.

Immunology

ISSN

0019-2805

Published

1979-11-00

Pages

497-502

Language

English

Region

England

NLM ID

0374672

PMCID

PMC1457848

Subset

External Links

PubMed source PMC Full Text View journal details

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The immune response of mice to bacterial antigens given by mouth.

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