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PMID: 4589991 Published · ppublish English Journal Article

Functional characteristics of Peyer's patch lymphoid cells. I. Induction of humoral antibody and cell-mediated allograft reactions.

The Journal of experimental medicine ·Vol. 139 ·No. 2 ·1974-02-01 ·Pages 398-406

Kagnoff MF, Campbell S

Abstract

Peyer's patches from normal mice contain antigen-sensitive B and T cells, but lack the accessory adherent cell type(s) required both for the induction of humoral immune responses and for the induction of allograft reactions against cell surface alloantigens. Immune responsiveness can be restored to cultures of Peyer's patch cells by the addition of either APEC or ME. Peyer's patch B cells can be specifically induced by antigen to synthesize humoral antibody. Peyer's patch T cells can cooperate in B-cell induction and can be induced to mediate an allograft reaction against an allogeneic stimulus. Peyer's patch lymphoid aggregates appear to be a storehouse of antigen-sensitive cells sequestered in such a way as to lack an accessory cell type or factor required for induction,

MeSH Terms
Animals Antibody Formation/drug effects Antigen-Antibody Reactions Ascitic Fluid/cytology B-Lymphocytes/immunology Cells, Cultured Chromium Radioisotopes Cytotoxicity Tests, Immunologic Erythrocytes/immunology Hemolytic Plaque Technique Histocompatibility Antigens Horses/immunology Immunity, Cellular/drug effects Lymphoid Tissue/immunology Macrophages/immunology Mercaptoethanol/pharmacology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred Strains Peyer's Patches/cytology,immunology Sheep/immunology T-Lymphocytes/immunology
Chemicals
Chromium Radioisotopes Histocompatibility Antigens Mercaptoethanol
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kagnoff M F
Campbell S
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26 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.139.2.398
Published
1974-02-01
Pages
398-406
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2139531
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.139.2.398 PMC Full Text View journal details
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