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PMID: 8858568 Published · ppublish English Journal Article Review

Signals controlling the expression of PDGF.

Molecular biology reports ·Vol. 22 ·No. 1 ·1995-00-00 ·Pages 1-24

Dirks RP, Bloemers HP

Abstract

PDGF is an important polypeptide growth factor that plays an essential role during early vertebrate development and is associated with tissue repair and wound healing in the adult vertebrate. Moreover, PDGF is thought to play a role in a variety of pathological phenomena, such as cancer, fibrosis and atherosclerosis. PDGF is expressed as a dimer of A and/or B chains, the precursors of which are encoded by two single copy genes. Although the PDGF genes are expressed coordinately in a number of cell types, they are independently expressed in a majority of cell types. The expression of either PDGF gene can be affected by very diverse extracellular stimuli and the type of response is dependent on the cell type that is exposed to the stimulus. Expression of the PDGF chains can be modulated at every imaginable level: by regulating accessibility of the transcription start site, by varying the transcription initiation rate, by using alternative transcription start sites, by alternative splicing, by using alternative polyadenylation signals, by varying mRNA decay rates, by regulating efficiency of translation, by protein modification, and by regulating secretion. Even upon secretion, the activity of PDGF can be modulated by non-specific or specific PDGF-binding proteins. This review provides an overview of the cell types in which the PDGF genes are expressed, of the factors that are known to affect the expression of PDGF, and of the various levels at which the expression of PDGF genes can be regulated.

MeSH Terms
Alternative Splicing Animals Blood Cells/physiology Cell Transformation, Neoplastic Embryonic and Fetal Development Endothelium, Vascular/physiology Fibroblasts/physiology Gene Expression Regulation Glomerular Mesangium/physiology Humans Muscle, Smooth/physiology Nervous System Physiological Phenomena Platelet-Derived Growth Factor/genetics,physiology Protein Biosynthesis Protein Processing, Post-Translational RNA, Messenger/genetics,metabolism Signal Transduction
Chemicals
Platelet-Derived Growth Factor RNA, Messenger
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Dirks R P
Department of Molecular Biology, University of Nijmegen, The Netherlands.
Bloemers H P
References (373)
373 references, click to expand
  1. Expression of c-sis and other cellular proto-oncogenes in human sarcoma cell lines and biopsies.
    Int J Cancer. 1989 Oct 15;44(4):652-7 PMID: 2793239
  2. Expression of platelet-derived growth factor (PDGF) and PDGF alpha- and beta-receptors in the peripheral nervous system: an analysis of sciatic nerve and dorsal root ganglia.
    Dev Biol. 1993 Feb;155(2):459-70 PMID: 8432400
  3. Identification of individual amino acids in platelet-derived growth factor that contribute to the specificity towards the beta-type receptor.
    FEBS Lett. 1992 May 18;302(3):265-8 PMID: 1318231
  4. Regulated expression of the platelet-derived growth factor A chain gene in microvascular endothelial cells.
    J Biol Chem. 1987 Oct 25;262(30):14381-4 PMID: 3478335
  5. Regulation of platelet-derived growth factor A messenger RNA translation in differentiating F9 teratocarcinoma cells.
    Cell Growth Differ. 1993 Oct;4(10):871-7 PMID: 8274456
  6. IL-1 beta-induced expression of PDGF-AA isoform in rabbit articular chondrocytes is modulated by TGF-beta 1.
    Exp Cell Res. 1991 Mar;193(1):208-12 PMID: 1995295
  7. Both homodimeric isoforms of PDGF (AA and BB) have mitogenic and chemotactic activity and stimulate phosphoinositol turnover.
    J Cell Physiol. 1989 Sep;140(3):558-64 PMID: 2550476
  8. PDGF receptors in the rat CNS: during late neurogenesis, PDGF alpha-receptor expression appears to be restricted to glial cells of the oligodendrocyte lineage.
    Development. 1992 Jun;115(2):535-51 PMID: 1425339
  9. Enhanced expression of the sis and c-myc oncogenes in human meningiomas.
    J Neurosurg. 1990 May;72(5):786-91 PMID: 2182793
  10. An S1 nuclease sensitive region in the PDGFA-chain gene promoter contains a positive transcriptional regulatory element.
    Biochem Biophys Res Commun. 1994 Jan 14;198(1):103-10 PMID: 8292011
  11. Platelet-derived growth factor and growth-related genes in rat lung. II. Effect of exposure to 85% O2.
    Am J Physiol. 1992 Feb;262(2 Pt 1):L140-6 PMID: 1311514
  12. Characterization of a tyrosine-specific kinase activity in human fibroblast membranes stimulated by platelet-derived growth factor.
    J Biol Chem. 1982 Sep 10;257(17):10486-92 PMID: 6980882
  13. Growth factor production by human thyroid carcinoma cells: abundant expression of a platelet-derived growth factor-B-like protein by a human papillary carcinoma cell line.
    J Clin Endocrinol Metab. 1993 Oct;77(4):996-1004 PMID: 8408476
  14. Differences in substrate specificities of alpha and beta platelet-derived growth factor (PDGF) receptors. Correlation with their ability to mediate PDGF transforming functions.
    J Biol Chem. 1993 May 5;268(13):9287-95 PMID: 8387491
  15. Cyclic AMP blocks expression of the c-sis gene in tumor cells.
    Oncogene Res. 1989;4(1):65-73 PMID: 2541392
  16. Arterial smooth muscle cells in primary culture produce a platelet-derived growth factor-like protein.
    Proc Natl Acad Sci U S A. 1985 Jul;82(13):4418-22 PMID: 2989820
  17. Retinal pigment epithelial cells produce PDGF-like proteins and secrete them into their media.
    Exp Eye Res. 1989 Aug;49(2):217-27 PMID: 2767169
  18. Differential regulation of platelet-derived growth factor genes in fetal rat lung fibroblasts.
    Exp Cell Res. 1994 Mar;211(1):142-9 PMID: 8125151
  19. Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulation.
    Proc Natl Acad Sci U S A. 1988 Oct;85(20):7748-52 PMID: 2845420
  20. Agents that increase cAMP accumulation block endothelial c-sis induction by thrombin and transforming growth factor-beta.
    J Biol Chem. 1987 Sep 5;262(25):11893-6 PMID: 3040721
  21. Fish oils inhibit endothelial cell production of platelet-derived growth factor-like protein.
    Science. 1988 Jul 22;241(4864):453-6 PMID: 3393911
  22. Developmental distribution of platelet-derived growth factor in the mouse central nervous system.
    Brain Res Dev Brain Res. 1992 Jun 19;67(2):121-35 PMID: 1324805
  23. Spontaneous production of PDGF A-chain homodimer by rat lung fibroblasts in vitro.
    Am J Physiol. 1992 Aug;263(2 Pt 1):L185-93 PMID: 1514643
  24. Distinct pathways mediate transcriptional regulation of platelet-derived growth factor B/c-sis expression.
    J Biol Chem. 1988 Dec 25;263(36):19815-20 PMID: 3198652
  25. Constitutive expression of multiple growth factor genes by melanoma cells but not normal melanocytes.
    J Invest Dermatol. 1991 Jul;97(1):20-6 PMID: 2056188
  26. Expression of platelet-derived growth factor receptors in the developing chicken lens.
    Invest Ophthalmol Vis Sci. 1994 Aug;35(9):3413-21 PMID: 8056516
  27. Detection of c-sis transcripts and synthesis of PDGF-like proteins by human osteosarcoma cells.
    Science. 1984 Nov 23;226(4677):972-4 PMID: 6209798
  28. Regulated expression of PDGF A-chain mRNA in human saphenous vein smooth muscle cells.
    Biochem Biophys Res Commun. 1991 Oct 31;180(2):519-24 PMID: 1953722
  29. Expression of platelet-derived growth factor B-chain in the mature rat brain and pituitary gland.
    Brain Res Mol Brain Res. 1995 Aug;32(1):63-74 PMID: 7494464
  30. Attachment of smooth muscle cells to collagen and their migration toward platelet-derived growth factor.
    Proc Natl Acad Sci U S A. 1981 Jun;78(6):3669-72 PMID: 6943570
  31. Role of PDGF-A expression in the control of vascular smooth muscle cell growth by transforming growth factor-beta.
    J Cell Biol. 1990 Jul;111(1):239-47 PMID: 1694856
  32. Sequences of the 5' portion of the human c-sis gene: characterization of the transcriptional promoter and regulation of expression of the protein product by 5' untranslated mRNA sequences.
    Nucleic Acids Res. 1987 Aug 11;15(15):6017-36 PMID: 3627977
  33. Vasoconstriction: a new activity for platelet-derived growth factor.
    Science. 1986 Apr 4;232(4746):87-90 PMID: 3485309
  34. Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factor.
    Nature. 1983 Oct 13-19;305(5935):605-8 PMID: 6312326
  35. Modulation of the sis gene transcript during endothelial cell differentiation in vitro.
    Science. 1985 May 17;228(4701):882-5 PMID: 3890179
  36. Platelet-derived growth factor-A and its receptor are expressed in separate, but adjacent cell layers of the mouse embryo.
    Development. 1992 Aug;115(4):1045-58 PMID: 1451656
  37. Platelet-derived growth factor in chemotactic for fibroblasts.
    J Cell Biol. 1982 Feb;92(2):584-8 PMID: 7061598
  38. Platelet derived growth factor-A chain gene expression in cultured mesangial cells: regulation by phorbol ester at the level of mRNA abundance, transcription and mRNA stability.
    Mol Cell Endocrinol. 1993 Feb;91(1-2):185-91 PMID: 8472849
  39. Production of PDGF-like growth factors by embryonal carcinoma cells and binding of PDGF to their endoderm-like differentiated cells.
    Dev Biol. 1985 Jul;110(1):15-22 PMID: 2989042
  40. Interferon-gamma suppresses PDGF production from THP-1 cells and blood monocyte-derived macrophages.
    Atherosclerosis. 1992 Nov;97(1):75-87 PMID: 1445496
  41. Rat brain capillary endothelial cells express functional PDGF B-type receptors.
    Growth Factors. 1989;2(1):1-8 PMID: 2561393
  42. Expression of the c-sis gene and secretion of a platelet-derived growth factor-like protein by simian virus 40-transformed BHK cells.
    Biochem Biophys Res Commun. 1985 Jul 31;130(2):753-60 PMID: 2992485
  43. Human microvascular endothelial cells express receptors for platelet-derived growth factor.
    Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):2021-5 PMID: 1848018
  44. PDGF B-chain in neurons of the central nervous system, posterior pituitary, and in a transgenic model.
    Cell. 1991 Jan 11;64(1):217-27 PMID: 1986868
  45. A role for platelet-derived growth factor in normal gliogenesis in the central nervous system.
    Cell. 1988 Apr 22;53(2):309-19 PMID: 2834067
  46. Expression of cellular oncogenes in human prostatic carcinoma cell lines.
    Biochem Biophys Res Commun. 1985 Oct 30;132(2):548-54 PMID: 3904752
  47. Interferon-gamma modulates messenger RNA levels of c-sis (PDGF-B chain), PDGF-A chain, and IL-1 beta genes in human vascular endothelial cells.
    Am J Pathol. 1989 Jan;134(1):35-43 PMID: 2492403
  48. Localization and functional analysis of DNase-I-hypersensitive sites in the human c-sis/PDGF-B gene transcription unit and its flanking regions.
    Eur J Biochem. 1993 Feb 1;211(3):509-19 PMID: 8436112
  49. Endotoxin stimulates platelet-derived growth factor production from cultured human pulmonary endothelial cells.
    Am J Physiol. 1989 Aug;257(2 Pt 1):L65-70 PMID: 2764117
  50. Platelet-derived growth factor A-chain gene transcription is mediated by positive and negative regulatory regions in the promoter.
    Biochem J. 1994 Jul 15;301 ( Pt 2):321-7 PMID: 8042973
  51. Signal transduction by the receptors for platelet-derived growth factor.
    J Cell Sci. 1990 Jun;96 ( Pt 2):193-6 PMID: 2170430
  52. Induction of platelet-derived growth factor gene expression during megakaryoblastic and monocytic differentiation of human leukemia cell lines.
    EMBO J. 1987 May;6(5):1213-8 PMID: 3475202
  53. The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors.
    Proc Natl Acad Sci U S A. 1992 Feb 15;89(4):1281-5 PMID: 1311092
  54. Fluid shear stress stimulates platelet-derived growth factor expression in endothelial cells.
    Am J Physiol. 1993 Jul;265(1 Pt 2):H3-8 PMID: 8342646
  55. Coexpression of the sis and myc proto-oncogenes in developing human placenta suggests autocrine control of trophoblast growth.
    Cell. 1985 May;41(1):301-12 PMID: 2986848
  56. Expression of c-sis and c-fos genes in human meningiomas and neurinomas.
    Int J Cancer. 1992 Jul 30;51(6):873-7 PMID: 1353485
  57. Negative trans-acting mechanisms controlling expression of platelet-derived growth factor A and B MRNA in somatic cell hybrids.
    Exp Cell Res. 1993 Aug;207(2):283-9 PMID: 8344381
  58. Demonstration of PDGF B-chain mRNA in glomeruli in mesangial proliferative nephritis by in situ hybridization.
    Kidney Int. 1991 Sep;40(3):470-6 PMID: 1724021
  59. Human meningiomas co-express platelet-derived growth factor (PDGF) and PDGF-receptor genes and their protein products.
    Int J Cancer. 1990 Jul 15;46(1):16-21 PMID: 2163990
  60. Structural basis for the extracellular retention of PDGF A-chain using a synthetic peptide corresponding to exon 6.
    Peptides. 1994 Jan;15(1):133-7 PMID: 8015969
  61. Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors.
    Nature. 1986 Sep 18-24;323(6085):226-32 PMID: 3020426
  62. Induction of platelet-derived growth factor A-chain and c-myc gene expressions by angiotensin II in cultured rat vascular smooth muscle cells.
    J Clin Invest. 1989 Apr;83(4):1419-24 PMID: 2649516
  63. Chromatin binding of epidermal growth factor, nerve growth factor, and platelet-derived growth factor in cells bearing the appropriate surface receptors.
    Proc Natl Acad Sci U S A. 1986 Jun;83(11):3728-32 PMID: 3012531
  64. Aberrant expression of platelet-derived growth factor A-chain cDNAs due to cryptic splicing of RNA transcripts in COS-1 cells.
    Nucleic Acids Res. 1989 Aug 25;17(16):6591-601 PMID: 2780289
  65. 5' untranslated sequences determine degradative pathway for alternate PDGF B/c-sis mRNA's.
    Oncogene. 1991 Jun;6(6):953-9 PMID: 2067847
  66. Purification of human platelet-derived growth factor.
    Proc Natl Acad Sci U S A. 1979 Apr;76(4):1809-13 PMID: 287022
  67. Thrombin stimulates c-sis gene expression in microvascular endothelial cells.
    J Biol Chem. 1986 Jul 25;261(21):9579-82 PMID: 2426251
  68. Enhancement of c-sis protooncogene transcription in bronchoalveolar mononuclear cells from patients with autoimmune diseases with lung involvement.
    Biochem Biophys Res Commun. 1989 Nov 15;164(3):1018-23 PMID: 2686632
  69. Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance.
    J Clin Invest. 1990 Jul;86(1):131-40 PMID: 2164040
  70. Blood pressure regulates platelet-derived growth factor A-chain gene expression in vascular smooth muscle cells in vivo. An autocrine mechanism promoting hypertensive vascular hypertrophy.
    J Clin Invest. 1995 Mar;95(3):1140-50 PMID: 7883963
  71. Phosphatidic acid modulates DNA synthesis, phospholipase C, and platelet-derived growth factor mRNAs in cultured mesangial cells. Role of protein kinase C.
    J Biol Chem. 1990 Aug 25;265(24):14457-63 PMID: 2167317
  72. Five PDGF B amino acid substitutions convert PDGF A to a PDGF B-like transforming molecule.
    J Biol Chem. 1992 Aug 25;267(24):17074-7 PMID: 1380958
  73. A human glioma cell line secretes three structurally and functionally different dimeric forms of platelet-derived growth factor.
    Eur J Biochem. 1988 Sep 1;176(1):179-86 PMID: 2458254
  74. Thrombin stimulates PDGF production and monocyte adhesion through distinct intracellular pathways in human endothelial cells.
    Am J Physiol. 1992 Jan;262(1 Pt 1):C199-206 PMID: 1310211
  75. Molecular localization of the transforming and secretory properties of PDGF A and PDGF B.
    Science. 1990 Jun 22;248(4962):1541-4 PMID: 2163109
  76. Developmental patterns of PDGF B-chain, PDGF-receptor, and alpha-actin expression in human glomerulogenesis.
    Kidney Int. 1992 Aug;42(2):390-9 PMID: 1405322
  77. Human platelet-derived growth factor (PDGF): amino-terminal amino acid sequence.
    Science. 1983 May 27;220(4600):963-5 PMID: 6844921
  78. The influence of oxidatively modified low density lipoproteins on expression of platelet-derived growth factor by human monocyte-derived macrophages.
    J Biol Chem. 1991 Jul 25;266(21):13901-7 PMID: 1906887
  79. Developmental expression of PDGF, TGF-alpha, and TGF-beta genes in preimplantation mouse embryos.
    Science. 1988 Sep 30;241(4874):1823-5 PMID: 3175624
  80. Identification and characterization of an essential, activating regulatory element of the human SIS/PDGFB promoter in human megakaryocytes.
    Proc Natl Acad Sci U S A. 1993 Aug 15;90(16):7563-7 PMID: 8356057
  81. Functional identification of regulatory elements within the promoter region of platelet-derived growth factor 2.
    Mol Cell Biol. 1989 Feb;9(2):396-405 PMID: 2651898
  82. Binding of single-stranded oligonucleotides to a non-B-form DNA structure results in loss of promoter activity of the platelet-derived growth factor A-chain gene.
    J Biol Chem. 1992 Jul 5;267(19):13669-74 PMID: 1618866
  83. Human iliac artery endothelial cells express both genes encoding the chains of platelet-derived growth factor (PDGF) and synthesize PDGF-like mitogen.
    J Cell Physiol. 1987 Aug;132(2):376-80 PMID: 3040782
  84. Chromosomal mapping of the simian sarcoma virus onc gene analogue in human cells.
    Proc Natl Acad Sci U S A. 1982 Aug;79(15):4691-5 PMID: 6289313
  85. Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains.
    Science. 1988 Sep 9;241(4871):1346-9 PMID: 2842868
  86. Activated human monocytes express the c-sis proto-oncogene and release a mediator showing PDGF-like activity.
    Nature. 1986 Jan 9-15;319(6049):158-60 PMID: 3941744
  87. Increased expression of growth factor mRNAs accompanies viral transformation of rodent cells.
    Oncogene Res. 1988;2(2):135-48 PMID: 3217109
  88. Platelet alpha granules contain a growth factor for fibroblasts.
    Blood. 1979 Jun;53(6):1043-52 PMID: 444648
  89. Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.
    Genes Dev. 1994 Aug 15;8(16):1888-96 PMID: 7958864
  90. In vivo footprinting and functional analysis of the human c-sis/PDGF B gene promoter provides evidence for two binding sites for transcriptional activators.
    Nucleic Acids Res. 1995 Apr 11;23(7):1119-26 PMID: 7739890
  91. Highly purified fibroblast-derived growth factor, an SV40-transformed fibroblast-secreted mitogen, is closely related to platelet-derived growth factor.
    EMBO J. 1985 Aug;4(8):1945-9 PMID: 2998776
  92. Exaggerated spontaneous release of platelet-derived growth factor by alveolar macrophages from patients with idiopathic pulmonary fibrosis.
    N Engl J Med. 1987 Jul 23;317(4):202-9 PMID: 3600711
  93. cDNA clones reveal differences between human glial and endothelial cell platelet-derived growth factor A-chains.
    Nature. 1987 Aug 13-19;328(6131):619-21 PMID: 3614363
  94. Production of platelet-derived growth factor-like mitogen by smooth-muscle cells from human atheroma.
    N Engl J Med. 1988 Jun 9;318(23):1493-8 PMID: 3367960
  95. Platelet-derived growth factor (PDGF) in oncogenesis: development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB.
    Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):393-7 PMID: 8380638
  96. Platelet-derived growth factor (PDGF) A-chain mRNA heterogeneity generated by the use of alternative promoters and alternative polyadenylation sites.
    Growth Factors. 1992;7(3):241-51 PMID: 1360804
  97. Successive activation of the platelet-derived growth factor beta receptor and platelet-derived growth factor B genes correlates with the genesis of human choriocarcinoma.
    Cancer Res. 1993 Jun 15;53(12):2927-31 PMID: 8504434
  98. Glucocorticoid inhibits thrombin-induced expression of platelet-derived growth factor A-chain and heparin-binding epidermal growth factor-like growth factor in human aortic smooth muscle cells.
    J Biol Chem. 1993 Oct 25;268(30):22941-7 PMID: 8226804
  99. Purification and properties of porcine platelet-derived growth factor.
    EMBO J. 1984 Dec 1;3(12):2963-7 PMID: 6526008
  100. Expression and developmental control of platelet-derived growth factor A-chain and B-chain/Sis genes in rat aortic smooth muscle cells.
    Proc Natl Acad Sci U S A. 1988 Mar;85(5):1524-8 PMID: 3278316
  101. Regulation of platelet-derived growth factor ligand and receptor gene expression by alpha-thrombin in vascular smooth muscle cells.
    Circ Res. 1992 Dec;71(6):1285-93 PMID: 1423927
  102. A tyrosinated peptide representing the alternatively spliced exon of the platelet-derived growth factor A-chain binds specifically to cultured cells and interferes with binding of several growth factors.
    J Biol Chem. 1992 Jan 25;267(3):1660-6 PMID: 1309790
  103. Role for platelet-derived growth factor-like and epidermal growth factor-like signaling pathways in gastrulation and spiculogenesis in the Lytechinus sea urchin embryo.
    Dev Dyn. 1995 Sep;204(1):77-88 PMID: 8563028
  104. Expression of the platelet-derived growth factor beta receptor during organogenesis and tissue differentiation in the mouse embryo.
    Dev Dyn. 1994 Mar;199(3):169-75 PMID: 8018985
  105. Differential expression of platelet-derived growth factor and transforming growth factor genes in small- and non-small-cell human lung carcinoma lines.
    Int J Cancer. 1988 Apr 15;41(4):636-41 PMID: 2833454
  106. PDGF signalling is required for gastrulation of Xenopus laevis.
    Development. 1995 Sep;121(9):3099-110 PMID: 7555734
  107. Differential regulation of the genes encoding platelet-derived growth factor receptor and its ligand in rat lung during microvascular and alveolar wall remodeling in hyperoxia.
    Am J Respir Cell Mol Biol. 1992 Sep;7(3):278-85 PMID: 1325810
  108. Alpha 1-adrenergic stimulation of platelet-derived growth factor A-chain gene expression in rat aorta.
    J Biol Chem. 1990 Jan 15;265(2):1082-8 PMID: 1688551
  109. Determination and expression of platelet-derived growth factor-AA in bone cell cultures.
    Endocrinology. 1992 Apr;130(4):1916-22 PMID: 1547719
  110. Generation of fibrosarcomas in vivo by a retrovirus that expresses the normal B chain of platelet-derived growth factor and mimics the alternative splice pattern of the v-sis oncogene.
    Proc Natl Acad Sci U S A. 1989 Apr;86(8):2693-7 PMID: 2649890
  111. Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factor.
    Nature. 1982 Feb 4;295(5848):419-20 PMID: 6173766
  112. Arterial smooth muscle cells express platelet-derived growth factor (PDGF) A chain mRNA, secrete a PDGF-like mitogen, and bind exogenous PDGF in a phenotype- and growth state-dependent manner.
    J Cell Biol. 1988 Feb;106(2):403-13 PMID: 2828383
  113. SIS/PDGF-B expression in benign and malignant human breast lesions.
    Oncogene. 1989 Mar;4(3):351-4 PMID: 2649848
  114. Platelet-derived growth factor mRNA detection in human atherosclerotic plaques by in situ hybridization.
    J Clin Invest. 1988 Sep;82(3):1134-43 PMID: 2843568
  115. Novel human PDGFA gene transcripts derived by alternative mRNA splicing.
    Gene. 1991 Feb 15;98(2):295-8 PMID: 2016070
  116. Regulation of expression of the c-sis proto-oncogene.
    Nucleic Acids Res. 1989 Jun 12;17(11):4101-15 PMID: 2740212
  117. Differentially regulated production of platelet-derived growth factor and of transforming growth factor beta by a human teratocarcinoma cell line.
    Differentiation. 1988 Sep;38(3):203-10 PMID: 3215396
  118. Platelet-derived growth factor is an autocrine growth stimulator in retinal pigmented epithelial cells.
    J Cell Sci. 1994 Sep;107 ( Pt 9):2459-69 PMID: 7844163
  119. Expression of the human PDGF-B gene is regulated by both positively and negatively acting cell type-specific regulatory elements located in the first intron.
    EMBO J. 1991 Jun;10(6):1365-73 PMID: 2026139
  120. Cell death and control of cell survival in the oligodendrocyte lineage.
    Cell. 1992 Jul 10;70(1):31-46 PMID: 1623522
  121. Developmentally regulated production of platelet-derived growth factor-like molecules.
    Nature. 1984 Oct 18-24;311(5987):669-71 PMID: 6090952
  122. Regulated production of a pleiotropic cytokine-platelet-derived growth factor--by differentiating erythroid cells in vitro and in vivo.
    Proc Natl Acad Sci U S A. 1995 May 23;92(11):4967-71 PMID: 7761433
  123. Gene regulation by the 5'-untranslated region of the platelet-derived growth factor A-chain.
    Biochim Biophys Acta. 1994 Jul 21;1222(3):511-4 PMID: 7518695
  124. Expression of mouse PDGF-A and PDGF alpha-receptor genes during pre- and post-implantation development: evidence for a developmental shift from an autocrine to a paracrine mode of action.
    Mech Dev. 1992 Dec;39(3):181-91 PMID: 1292572
  125. cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules.
    Mol Cell Biol. 1988 Aug;8(8):3476-86 PMID: 2850496
  126. Human keratinocytes are a major source of cutaneous platelet-derived growth factor.
    J Clin Invest. 1993 Aug;92(2):671-8 PMID: 8349805
  127. Mitogenic signals for thrombin in mesangial cells: regulation of phospholipase C and PDGF genes.
    Am J Physiol. 1989 Sep;257(3 Pt 2):F366-74 PMID: 2551185
  128. Coexpression of the genes for platelet-derived growth factor and its receptor in human T-cell lines infected with HTLV-I.
    Growth Factors. 1990;2(2-3):189-95 PMID: 2160260
  129. Induction of platelet-derived growth factor A and B chains and over-expression of their receptors in human pancreatic cancer.
    Int J Cancer. 1995 Sep 4;62(5):529-35 PMID: 7665222
  130. Chrysotile asbestos stimulates platelet-derived growth factor-AA production by rat lung fibroblasts in vitro: evidence for an autocrine loop.
    Am J Respir Cell Mol Biol. 1995 Feb;12(2):162-70 PMID: 7865215
  131. Platelet-derived growth factor (PDGF)-induced disulfide-linked dimerization of PDGF receptor in living cells.
    Mol Cell Biol. 1991 Jul;11(7):3756-61 PMID: 1646395
  132. Platelet-derived growth factor gene expression in human atherosclerotic plaques and normal artery wall.
    Proc Natl Acad Sci U S A. 1988 Apr;85(8):2810-4 PMID: 3282240
  133. Compartmentalization of PDGF on extracellular binding sites dependent on exon-6-encoded sequences.
    J Cell Biol. 1992 Jan;116(2):533-43 PMID: 1309814
  134. Comparison of production of transforming growth factor-beta and platelet-derived growth factor by normal human mesothelial cells and mesothelioma cell lines.
    Cancer Res. 1987 Dec 1;47(23):6180-4 PMID: 3479241
  135. Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop.
    Int J Cancer. 1995 Jan 17;60(2):168-73 PMID: 7829210
  136. Promoter region of the human platelet-derived growth factor A-chain gene.
    Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):1686-90 PMID: 1848007
  137. Two different subunits associate to create isoform-specific platelet-derived growth factor receptors.
    J Biol Chem. 1989 May 25;264(15):8771-8 PMID: 2542288
  138. Induction of platelet-derived growth factor chain A gene expression in human smooth muscle cells by oxidized low density lipoproteins.
    Biochem Biophys Res Commun. 1992 Aug 14;186(3):1410-6 PMID: 1510670
  139. Lipoprotein-mediated inhibition of endothelial cell production of platelet-derived growth factor-like protein depends on free radical lipid peroxidation.
    J Biol Chem. 1987 May 5;262(13):6046-54 PMID: 3571245
  140. Structure and sequence of the human c-sis/platelet-derived growth factor 2 (SIS/PDGF2) transcriptional unit.
    Proc Natl Acad Sci U S A. 1986 Apr;83(8):2392-6 PMID: 3517869
  141. A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains.
    Nature. 1986 Feb 6-12;319(6053):511-4 PMID: 3456080
  142. Expression and stability of c-sis mRNA in human glioblastoma cells.
    Biochemistry. 1988 Jul 26;27(15):5736-41 PMID: 3052584
  143. Nuclear factor-kappa B interacts functionally with the platelet-derived growth factor B-chain shear-stress response element in vascular endothelial cells exposed to fluid shear stress.
    J Clin Invest. 1995 Aug;96(2):1169-75 PMID: 7635955
  144. PDGF and its receptors following facial nerve axotomy in rats: expression in neurons and surrounding glia.
    Exp Brain Res. 1995;102(3):415-22 PMID: 7737388
  145. Chemical and biological properties of a growth factor from human-cultured osteosarcoma cells: resemblance with platelet-derived growth factor.
    J Cell Physiol. 1980 Nov;105(2):235-46 PMID: 6936400
  146. TGF-beta induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop.
    Cell. 1990 Nov 2;63(3):515-24 PMID: 2171777
  147. SIS/PDGF-B promoter isolation and characterization of regulatory elements necessary for basal expression of the SIS/PDGF-B gene in U2-OS osteosarcoma cells.
    J Biol Chem. 1994 Nov 18;269(46):28648-54 PMID: 7961814
  148. Angiogenesis during human extraembryonic development involves the spatiotemporal control of PDGF ligand and receptor gene expression.
    Development. 1991 Nov;113(3):749-54 PMID: 1668277
  149. Modulation of platelet-derived growth factor A- and B-chain/c-sis mRNA by tumor necrosis factor and other agents in adenocarcinoma cells.
    Oncogene. 1991 Jun;6(6):1015-21 PMID: 1906154
  150. Platelet derived growth factor (PDGF) stimulates development of bovine embryos during the fourth cell cycle.
    Development. 1992 Jul;115(3):821-6 PMID: 1425356
  151. Synthesis and secretion of platelet-derived growth factor by human breast cancer cell lines.
    Proc Natl Acad Sci U S A. 1987 Aug;84(16):5763-7 PMID: 3039506
  152. Identification of the glucocorticoid suppressible mitogen from rat hepatoma cells as an angiogenic platelet-derived growth factor A-chain homodimer.
    J Biol Chem. 1991 Sep 25;266(27):18299-307 PMID: 1917957
  153. Platelet-derived growth factor ligand and receptor expression by large vessel endothelium in vivo.
    Am J Pathol. 1995 Jun;146(6):1488-97 PMID: 7778687
  154. Dexamethasone-induced increase in platelet-derived growth factor (B) mRNA in human alveolar macrophages and myelomonocytic HL60 macrophage-like cells.
    Am J Respir Cell Mol Biol. 1992 Aug;7(2):198-206 PMID: 1497907
  155. Human malignant mesothelioma cell lines express PDGF beta-receptors whereas cultured normal mesothelial cells express predominantly PDGF alpha-receptors.
    Oncogene. 1991 Nov;6(11):2005-11 PMID: 1658707
  156. Production of platelet-derived growth factorlike protein by rat mesangial cells in culture.
    J Clin Invest. 1987 Sep;80(3):675-83 PMID: 3624483
  157. Oxygen tension regulates the expression of the platelet-derived growth factor-B chain gene in human endothelial cells.
    J Clin Invest. 1990 Aug;86(2):670-4 PMID: 2384608
  158. Mesangial cells express PDGF mRNAs and proliferate in response to PDGF.
    Am J Physiol. 1988 Oct;255(4 Pt 2):F674-84 PMID: 2845810
  159. Identification of processing events in the synthesis of platelet-derived growth factor-like proteins by human osteosarcoma cells.
    Proc Natl Acad Sci U S A. 1986 Jul;83(13):4636-40 PMID: 3460062
  160. Production of growth factors related to fibroblast growth factor and platelet-derived growth factor by human embryonal carcinoma cells.
    In Vitro Cell Dev Biol. 1988 Dec;24(12):1209-16 PMID: 3209587
  161. Platelets as a source of fibroblast growth-promoting activity.
    Exp Cell Res. 1974 Aug;87(2):297-301 PMID: 4370268
  162. An S1 nuclease-sensitive region in the first intron of human platelet-derived growth factor A-chain gene contains a negatively acting cell type-specific regulatory element.
    Nucleic Acids Res. 1994 Feb 11;22(3):457-64 PMID: 8127685
  163. A novel human c-sis mRNA species is transcribed from a promoter in c-sis intron 1 and contains the code for an alternative PDGF B-like protein.
    Nucleic Acids Res. 1995 Aug 11;23(15):2815-22 PMID: 7659502
  164. Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element.
    Proc Natl Acad Sci U S A. 1993 May 15;90(10):4591-5 PMID: 8506304
  165. Upregulation of platelet-derived growth factor-A and -B gene expression in alveolar macrophages of individuals with idiopathic pulmonary fibrosis.
    J Clin Invest. 1990 Jun;85(6):2023-7 PMID: 2347924
  166. Human-proto-oncogene nucleotide sequences corresponding to the transforming region of simian sarcoma virus.
    Science. 1984 Feb 3;223(4635):487-91 PMID: 6318322
  167. The Wilms' tumor gene product WT1 activates or suppresses transcription through separate functional domains.
    J Biol Chem. 1993 May 5;268(13):9172-5 PMID: 8486616
  168. The translational repression mediated by the platelet-derived growth factor 2/c-sis mRNA leader is relieved during megakaryocytic differentiation.
    J Biol Chem. 1995 May 5;270(18):10559-65 PMID: 7737991
  169. Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing.
    Proc Natl Acad Sci U S A. 1988 Mar;85(5):1492-6 PMID: 3422746
  170. Coexpression of platelet-derived growth factor (PDGF) A-chain and PDGF receptor genes in human gastric carcinomas.
    Jpn J Cancer Res. 1989 Sep;80(9):813-7 PMID: 2557315
  171. Actions of platelet-derived growth factor isoforms in mesangial cells.
    J Cell Physiol. 1994 Jan;158(1):140-50 PMID: 8263021
  172. Accumulation of PDGF B and cell-binding forms of PDGF A in the extracellular matrix.
    J Cell Biol. 1993 Jun;121(5):1153-63 PMID: 8501120
  173. Two classes of PDGF receptor recognize different isoforms of PDGF.
    Science. 1988 Jun 10;240(4858):1529-31 PMID: 2836952
  174. Structural characterization of the human platelet-derived growth factor A-chain cDNA and gene: alternative exon usage predicts two different precursor proteins.
    Mol Cell Biol. 1988 Feb;8(2):571-7 PMID: 2832727
  175. Platelet-derived growth factor gene expression in cultured human retinal pigment epithelial cells.
    Biochem Biophys Res Commun. 1992 Nov 30;189(1):66-71 PMID: 1280433
  176. Immunological study of in vitro maturation of human megakaryocytes.
    Br J Haematol. 1984 Apr;56(4):589-605 PMID: 6231944
  177. Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture.
    Nature. 1988 Jun 9;333(6173):562-5 PMID: 3287177
  178. Phorbol ester induces c-sis gene transcription in stem cell line K-562.
    Mol Cell Biol. 1986 May;6(5):1847-50 PMID: 3466024
  179. Alternatively spliced platelet-derived growth factor A-chain transcripts are not tumor specific but encode normal cellular proteins.
    Mol Cell Biol. 1990 Nov;10(11):6051-4 PMID: 2233732
  180. TGF-beta stimulates primary human skin fibroblast DNA synthesis via an autocrine production of PDGF-related peptides.
    J Cell Physiol. 1989 Aug;140(2):246-53 PMID: 2745561
  181. Effects of PDGF on inositol phosphates, Ca2+, and contraction of mesangial cells.
    Am J Physiol. 1987 Sep;253(3 Pt 2):F458-63 PMID: 3631281
  182. Neurotrophic activity of platelet-derived growth factor (PDGF): Rat neuronal cells possess functional PDGF beta-type receptors and respond to PDGF.
    Proc Natl Acad Sci U S A. 1991 Sep 15;88(18):8159-63 PMID: 1654560
  183. A novel mechanism regulating growth factor association with the cell surface: identification of a PDGF retention domain.
    Genes Dev. 1991 Jul;5(7):1191-9 PMID: 2065974
  184. Human platelet-derived growth factor. Purification and resolution into two active protein fractions.
    J Biol Chem. 1981 Sep 10;256(17):8896-9 PMID: 7263691
  185. Human osteoblasts synthesize and respond to platelet-derived growth factor.
    Am J Physiol. 1991 Aug;261(2 Pt 1):C348-54 PMID: 1831327
  186. Identification and characterization of polypeptide growth factors secreted by murine embryonal carcinoma cells.
    Dev Biol. 1989 May;133(1):272-83 PMID: 2651184
  187. Expression of c-sis/platelet-derived growth factor B, insulin-like growth factor I, and transforming growth factor alpha messenger RNAs and their respective receptor messenger RNAs in primary human gastric carcinomas: in vivo studies with in situ hybridization and immunocytochemistry.
    Cancer Res. 1992 Jun 15;52(12):3453-9 PMID: 1317752
  188. Medulloblastoma cell line secretes platelet-derived growth factor.
    Pediatr Neurol. 1989 Nov-Dec;5(6):347-52 PMID: 2604798
  189. Interleukin 6 modulates c-sis gene expression in cultured human endothelial cells.
    Cell Immunol. 1992 Aug;143(1):118-26 PMID: 1623561
  190. Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor.
    Science. 1983 Jul 15;221(4607):275-7 PMID: 6304883
  191. Expression of recombinant platelet-derived growth factor A- and B-chain homodimers in rat-1 cells and human fibroblasts reveals differences in protein processing and autocrine effects.
    Mol Cell Biol. 1988 Jul;8(7):2753-62 PMID: 3405217
  192. Thrombin-induced proliferation and expression of platelet-derived growth factor-A chain gene in human vascular smooth muscle cells.
    FEBS Lett. 1992 Dec 14;314(2):143-8 PMID: 1333990
  193. Differential expression of PDGF A- and B-chain genes and production of AA and AB dimers by activated human blood monocytes.
    Biochimie. 1992 Dec;74(12):1097-101 PMID: 1292618
  194. Human prostate adenocarcinomas express in-vivo messenger-rnas and protein products for platelet-derived growth factor-B and its receptor.
    Int J Oncol. 1993 Nov;3(5):809-15 PMID: 21573435
  195. Identification of a cell retention signal in the B-chain of platelet-derived growth factor and in the long splice version of the A-chain.
    Cell Regul. 1991 Jul;2(7):503-12 PMID: 1782212
  196. Platelet derived growth factor (PDGF) autocrine components in human tumor cell lines.
    J Neurooncol. 1990 Feb;8(1):1-12 PMID: 2156959
  197. Platelet-derived growth factor AA homodimer is the predominant isoform in human platelets and acute human wound fluid.
    FASEB J. 1992 Aug;6(11):2996-3001 PMID: 1644262
  198. Synthesis and secretion of proteins resembling platelet-derived growth factor by human glioblastoma and fibrosarcoma cells in culture.
    Proc Natl Acad Sci U S A. 1985 Apr;82(8):2404-8 PMID: 3857590
  199. PDGF A chain homodimers drive proliferation of bipotential (O-2A) glial progenitor cells in the developing rat optic nerve.
    EMBO J. 1989 Apr;8(4):1049-56 PMID: 2545439
  200. Shear-induced platelet-derived growth factor gene expression in human endothelial cells is mediated by protein kinase C.
    J Cell Physiol. 1992 Mar;150(3):552-8 PMID: 1537884
  201. Production of PDGF-like growth factor by breast cancer cell lines.
    Int J Cancer. 1985 Aug 15;36(2):247-52 PMID: 2991148
  202. Proliferation of oligodendrocyte precursor cells depends on electrical activity in axons.
    Nature. 1993 Jan 21;361(6409):258-60 PMID: 8093806
  203. Functional analysis of the human platelet-derived growth factor A-chain promoter region.
    J Biol Chem. 1992 Dec 15;267(35):25614-9 PMID: 1460057
  204. Developmental expression of platelet-derived growth factor and its receptor in the human placenta.
    Mol Endocrinol. 1988 Jul;2(7):627-32 PMID: 2457800
  205. Expression of the platelet-derived growth factor 1 and 2 genes in human myeloid cell lines and monocytes.
    Cancer Res. 1988 Aug 15;48(16):4498-502 PMID: 3165051
  206. Regulation of platelet-derived growth factor gene expression by transforming growth factor beta and phorbol ester in human leukemia cell lines.
    Mol Cell Biol. 1987 Oct;7(10):3656-62 PMID: 3479682
  207. Induction of fos and sis proto-oncogenes and genes of the extracellular matrix proteins during butyrate induced glioma differentiation.
    Biochim Biophys Acta. 1990 Jan 30;1048(1):59-65 PMID: 2105102
  208. Nucleotide sequence analysis identifies the human c-sis proto-oncogene as a structural gene for platelet-derived growth factor.
    Cell. 1984 May;37(1):123-9 PMID: 6327048
  209. The biology of platelet-derived growth factor.
    Cell. 1986 Jul 18;46(2):155-69 PMID: 3013421
  210. Triggering signaling cascades by receptor tyrosine kinases.
    Trends Biochem Sci. 1992 Oct;17(10):374-8 PMID: 1455504
  211. Expression of platelet-derived growth factor (PDGF)-related transcripts and synthesis of biologically active PDGF-like proteins by human malignant epithelial cell lines.
    J Clin Invest. 1988 Oct;82(4):1157-64 PMID: 2844850
  212. Platelet-derived growth factor and alternative splicing: a review.
    Pathology. 1992 Oct;24(4):280-90 PMID: 1289770
  213. Cultured endothelial cells produce a platelet-derived growth factor-like protein.
    Proc Natl Acad Sci U S A. 1983 Apr;80(7):1919-23 PMID: 6300879
  214. A glioma-derived analog to platelet-derived growth factor: demonstration of receptor competing activity and immunological crossreactivity.
    Proc Natl Acad Sci U S A. 1984 Feb;81(3):926-30 PMID: 6322178
  215. Induction of c-sis gene expression and synthesis of platelet-derived growth factor in human myeloid leukemia cells during monocytic differentiation.
    Proc Natl Acad Sci U S A. 1986 Sep;83(17):6455-9 PMID: 3529084
  216. The response of cultured human normal glial cells to growth factors.
    Adv Metab Disord. 1975;8:85-100 PMID: 1106160
  217. Regulation of mesangial cell growth by polypeptide mitogens. Inhibitory role of transforming growth factor beta.
    Am J Pathol. 1989 Aug;135(2):261-9 PMID: 2782372
  218. Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells.
    Nature. 1982 Jan 14;295(5845):116-9 PMID: 6173755
  219. A significant part of macrophage-derived growth factor consists of at least two forms of PDGF.
    Cell. 1985 Nov;43(1):277-86 PMID: 2416458
  220. Alpha-thrombin induces release of platelet-derived growth factor-like molecule(s) by cultured human endothelial cells.
    J Cell Biol. 1986 Sep;103(3):1129-33 PMID: 3745265
  221. Heparin-binding growth factor-1 stimulation of human endothelial cells induces platelet-derived growth factor A-chain gene expression.
    J Biol Chem. 1990 Feb 25;265(6):3284-92 PMID: 1689299
  222. Tumor necrosis factor-induced expression of platelet-derived growth factor A-chain messenger RNA in fibroblasts.
    Exp Cell Res. 1989 Feb;180(2):490-6 PMID: 2536613
  223. Reversible binding of platelet-derived growth factor-AA, -AB, and -BB isoforms to a similar site on the "slow" and "fast" conformations of alpha 2-macroglobulin.
    J Biol Chem. 1992 Jun 25;267(18):12837-44 PMID: 1377675
  224. The effects of platelet-derived growth factor in cultured microvessel endothelial cells.
    Endocrinology. 1989 Apr;124(4):1841-8 PMID: 2924726
  225. Growth factor production by human colon carcinoma cell lines.
    Cancer Res. 1989 Jun 1;49(11):2898-904 PMID: 2541895
  226. Endothelin stimulates PDGF secretion in cultured human mesangial cells.
    Kidney Int. 1990 Dec;38(6):1193-8 PMID: 2074661
  227. Visceral glomerular epithelial cells can proliferate in vivo and synthesize platelet-derived growth factor B-chain.
    Am J Pathol. 1993 Feb;142(2):637-50 PMID: 8434653
  228. Cloning a novel form of rat PDGF A-chain with a unique 5'-UT: regulation during development and in glomerulonephritis.
    Biochem Biophys Res Commun. 1993 Aug 16;194(3):1453-9 PMID: 8352804
  229. Signal transduction by the platelet-derived growth factor receptor.
    Science. 1989 Mar 24;243(4898):1564-70 PMID: 2538922
  230. Expression of c-sis (PDGF B-chain) and PDGF A-chain genes in ten human malignant mesothelioma cell lines derived from primary and metastatic tumors.
    Oncogene. 1988 Jun;2(6):601-5 PMID: 3290807
  231. Specific covalent binding of platelet-derived growth factor to human plasma alpha 2-macroglobulin.
    Proc Natl Acad Sci U S A. 1984 Jan;81(2):342-6 PMID: 6198647
  232. Platelet-derived growth factor: purification and partial characterization.
    Proc Natl Acad Sci U S A. 1979 Aug;76(8):3722-6 PMID: 291037
  233. Synthetic peptides representing the alternatively spliced exon of the platelet-derived growth factor A-chain modulate mitogenesis stimulated by normal human serum and several growth factors.
    J Biol Chem. 1992 Apr 15;267(11):7478-82 PMID: 1559986
  234. A major part of platelet-derived growth factor purified from human platelets is a heterodimer of one A and one B chain.
    J Biol Chem. 1988 Nov 5;263(31):16493-8 PMID: 2460450
  235. Cultured Kaposi's sarcoma-derived cells express functional PDGF A-type and B-type receptors.
    Exp Cell Res. 1990 Mar;187(1):98-103 PMID: 2153568
  236. Expression of the insulin-like and platelet-derived growth factor genes in human uterine tissues.
    Mol Reprod Dev. 1990 Oct;27(2):93-101 PMID: 1979007
  237. Increased expression of PDGF A- and B-chain genes in rat lungs with hypoxic pulmonary hypertension.
    Am J Physiol. 1993 Feb;264(2 Pt 1):L100-6 PMID: 8447423
  238. PDGF ligand and receptor gene expression during repair of arterial injury.
    J Cell Biol. 1990 Nov;111(5 Pt 1):2149-58 PMID: 2172262
  239. Transcriptional control of the platelet-derived growth factor subunit genes.
    Biofactors. 1993 May;4(2):71-81 PMID: 8347277
  240. Selective expression of PDGF A and its receptor during early mouse embryogenesis.
    Dev Biol. 1990 Mar;138(1):114-22 PMID: 2155144
  241. Growth factor messenger RNA expression by human breast fibroblasts from benign and malignant lesions.
    Cancer Res. 1991 Sep 15;51(18):4978-85 PMID: 1893385
  242. Interleukin-1 mitogenic activity for fibroblasts and smooth muscle cells is due to PDGF-AA.
    Science. 1989 Jan 20;243(4889):393-6 PMID: 2783498
  243. Localization of PDGF-B protein in macrophages in all phases of atherogenesis.
    Science. 1990 May 25;248(4958):1009-12 PMID: 2343305
  244. Age related induction of platelet-derived growth factor A-chain mRNA in normal human fibroblasts.
    J Cell Physiol. 1994 Feb;158(2):256-62 PMID: 8106562
  245. Multiple elements in the 5' untranslated region down-regulate c-sis messenger RNA translation.
    Cell Growth Differ. 1995 Sep;6(9):1103-10 PMID: 8519687
  246. Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class.
    Proc Natl Acad Sci U S A. 1988 May;85(10):3435-9 PMID: 2835772
  247. cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines.
    Nature. 1986 Apr 24-30;320(6064):695-9 PMID: 3754619
  248. Structure and function of platelet-derived growth factor (PDGF) and related proteins.
    Biochim Biophys Acta. 1989 Jul 28;989(1):1-10 PMID: 2546599
  249. Platelet-derived growth factor ligand and receptor subunit mRNA in the Sertoli and Leydig cells of the rat testis.
    Mol Cell Endocrinol. 1995 Feb 27;108(1-2):155-9 PMID: 7758829
  250. Expression of platelet-derived growth factor and its receptors in neuroendocrine tumors of the digestive system.
    Cancer Res. 1992 Feb 15;52(4):1006-12 PMID: 1310635
  251. Production of platelet-derived growth factor by cultured Wilms' tumor cells and fetal kidney cells.
    J Cell Physiol. 1987 Oct;133(1):169-74 PMID: 2444606
  252. Production of platelet-derived growth factor-like molecules by cultured arterial smooth muscle cells accompanies proliferation after arterial injury.
    Proc Natl Acad Sci U S A. 1986 Oct;83(19):7311-5 PMID: 3020543
  253. Human melanoma cell lines of primary and metastatic origin express the genes encoding the chains of platelet-derived growth factor (PDGF) and produce a PDGF-like growth factor.
    Proc Natl Acad Sci U S A. 1986 Oct;83(19):7197-200 PMID: 3020539
  254. Two peptides related to platelet-derived growth factor are present in human wound fluid.
    Proc Natl Acad Sci U S A. 1989 Jun;86(12):4416-20 PMID: 2734294
  255. Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus.
    Nature. 1983 Jul 7-13;304(5921):35-9 PMID: 6306471
  256. Coexpression of a PDGF-like growth factor and PDGF receptors in a human osteosarcoma cell line: implications for autocrine receptor activation.
    Cell. 1984 Dec;39(3 Pt 2):447-57 PMID: 6096004
  257. Structure and nucleotide sequence of the 5' region of the human and feline c-sis proto-oncogenes.
    Nucleic Acids Res. 1986 Jan 24;14(2):765-78 PMID: 3003695
  258. Injury induces in vivo expression of platelet-derived growth factor (PDGF) and PDGF receptor mRNAs in skin epithelial cells and PDGF mRNA in connective tissue fibroblasts.
    Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):565-9 PMID: 1846446
  259. Effects of interferon-gamma on proto-oncogene expression during induction of human monocytic differentiation.
    J Immunol. 1987 Mar 15;138(6):1954-8 PMID: 3102606
  260. Modified low density lipoproteins suppress production of a platelet-derived growth factor-like protein by cultured endothelial cells.
    Proc Natl Acad Sci U S A. 1986 Jul;83(13):4774-8 PMID: 3460071
  261. Expression of platelet-derived growth factor and its receptor in AIDS-related Kaposi sarcoma in vivo suggests paracrine and autocrine mechanisms of tumor maintenance.
    Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7046-50 PMID: 1323124
  262. Plasma binding proteins for platelet-derived growth factor that inhibit its binding to cell-surface receptors.
    Proc Natl Acad Sci U S A. 1984 Jun;81(11):3424-8 PMID: 6203121
  263. New roles for PDGF and CNTF in controlling the timing of glial cell differentiation in the optic nerve.
    Trends Neurosci. 1989 Mar;12(3):83-5 PMID: 2469220
  264. Platelet-derived growth factor synthesis in mesangial cells: induction by multiple peptide mitogens.
    Proc Natl Acad Sci U S A. 1989 Feb;86(3):1056-60 PMID: 2536931
  265. Platelet-derived growth factor (PDGF) and PDGF receptor are induced in mesangial proliferative nephritis in the rat.
    Proc Natl Acad Sci U S A. 1991 Aug 1;88(15):6560-4 PMID: 1713682
  266. Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-alpha and their receptors in human malignant glioma cell lines.
    Cancer Res. 1988 Jul 15;48(14):3910-8 PMID: 2454731
  267. Novel cis-acting elements in the human platelet-derived growth factor B-chain core promoter that mediate gene expression in cultured vascular endothelial cells.
    J Biol Chem. 1994 Sep 9;269(36):22647-56 PMID: 8077216
  268. The expression of the platelet-derived and transforming growth factor genes in human nonsmall lung cancer cell lines is related to tumor stroma formation in nude mice tumors.
    Am J Pathol. 1988 Dec;133(3):434-9 PMID: 2849299
  269. Expression of multiple growth factors in a human lung cancer cell line.
    Int J Cancer. 1987 Apr 15;39(4):502-7 PMID: 3030941
  270. Cultured human endothelial cells express platelet-derived growth factor A chain.
    Am J Pathol. 1987 Jan;126(1):7-12 PMID: 2433948
  271. Platelet-derived growth factor production by human umbilical vein endothelial cells is regulated by basic fibroblast growth factor.
    J Biol Chem. 1989 Mar 15;264(8):4456-9 PMID: 2925652
  272. Effect of the different dimeric forms of the platelet-derived growth factor on cellular responses in mouse Swiss 3T3 fibroblasts.
    FEBS Lett. 1989 Sep 11;255(1):191-5 PMID: 2551728
  273. Structure of the murine c-sis proto-oncogene (Sis, PDGFB) encoding the B chain of platelet-derived growth factor.
    Genomics. 1991 May;10(1):287-92 PMID: 2045107
  274. Fluid shear stress differentially modulates expression of genes encoding basic fibroblast growth factor and platelet-derived growth factor B chain in vascular endothelium.
    J Clin Invest. 1993 Oct;92(4):2013-21 PMID: 8408655
  275. Expression of cellular oncogenes during embryonic and fetal development of the mouse.
    Proc Natl Acad Sci U S A. 1984 Nov;81(22):7141-5 PMID: 6594688
  276. Alternative splicing of the platelet-derived growth factor A-chain transcript occurs in normal as well as tumor cells and is conserved among mammalian species.
    Mol Cell Biol. 1989 Jul;9(7):3148-50 PMID: 2779559
  277. Platelets, platelet-derived growth factor and arteriosclerosis.
    Experientia. 1988 Feb 15;44(2):109-12 PMID: 3278918
  278. Synthesis of PDGF by cultured human T cells transformed with HTLV-I and II.
    Oncogene. 1987;1(3):285-9 PMID: 2838779
  279. Synthesis and assembly of a functionally active recombinant platelet-derived growth factor AB heterodimer.
    J Biol Chem. 1988 Nov 5;263(31):16202-8 PMID: 2846538
  280. Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor cell.
    Nature. 1988 Jun 9;333(6173):560-2 PMID: 3287176
  281. Platelet-derived growth factor. Phorbol ester induces the expression of the B-chain but not of the A-chain in HEL cells.
    FEBS Lett. 1987 Mar 9;213(1):89-94 PMID: 3470198
  282. Dimerization of B-type platelet-derived growth factor receptors occurs after ligand binding and is closely associated with receptor kinase activation.
    J Biol Chem. 1989 May 25;264(15):8905-12 PMID: 2542295
  283. Localization of PDGF A and PDGFR alpha mRNA in Xenopus embryos suggests signalling from neural ectoderm and pharyngeal endoderm to neural crest cells.
    Mech Dev. 1994 Dec;48(3):165-74 PMID: 7893600
  284. Expression of the normal human sis/PDGF-2 coding sequence induces cellular transformation.
    Cell. 1984 Nov;39(1):89-97 PMID: 6091919
  285. Expression of platelet-derived growth factor and its receptor in rat neuronal and astroglial cultures.
    Mol Cell Neurosci. 1993 Jun;4(3):250-8 PMID: 19912930
  286. Platelet-derived growth factor in idiopathic pulmonary fibrosis.
    J Clin Invest. 1990 Oct;86(4):1055-64 PMID: 2170444
  287. Platelet-derived growth factor stimulates tyrosine-specific protein kinase activity in Swiss mouse 3T3 cell membranes.
    Proc Natl Acad Sci U S A. 1982 Jul;79(14):4303-7 PMID: 6181505
  288. Transcriptional regulation of the A and B chain genes of platelet-derived growth factor in microvascular endothelial cells.
    J Biol Chem. 1988 Jun 15;263(17):8470-2 PMID: 3372537
  289. Transformation of NIH 3T3 cells by a human c-sis cDNA clone.
    Nature. 1984 Mar 29-Apr 4;308(5958):464-7 PMID: 6323994
  290. Genetic organization of the c-sis transcription unit.
    Nucleic Acids Res. 1987 Feb 11;15(3):959-70 PMID: 3822831
  291. Expression of platelet-derived growth factor (PDGF) and PDGF receptor genes in the developing rat brain.
    J Neurosci Res. 1992 Apr;31(4):670-7 PMID: 1315873
  292. Transforming potential of human c-sis nucleotide sequences encoding platelet-derived growth factor.
    Science. 1984 Aug 10;225(4662):636-9 PMID: 6740330
  293. Human platelet-derived growth factor (PDGF): purification of PDGF-I and PDGF-II and separation of their reduced subunits.
    Proc Natl Acad Sci U S A. 1981 Dec;78(12):7314-7 PMID: 6950377
  294. Detection of PDGF-2 homodimers in human tumor cells.
    Oncogene. 1987 Mar;1(1):79-85 PMID: 3325876
  295. Human peripheral blood monocytes secrete a unique form of PDGF.
    Oncogene Res. 1988;3(4):333-42 PMID: 3067188
  296. The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor.
    EMBO J. 1984 May;3(5):921-8 PMID: 6329745
  297. Enhancement of c-sis proto-oncogene transcription in bronchoalveolar mononuclear cells from patients with pulmonary sarcoidosis.
    J Clin Pathol. 1990 Apr;43(4):295-7 PMID: 2341565
  298. Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.
    Genes Dev. 1994 Aug 15;8(16):1875-87 PMID: 7958863
  299. Stable expression of human platelet-derived growth factor B chain by bovine aortic endothelial cells. Matrix association and selective proteolytic cleavage by thrombin.
    J Biol Chem. 1994 Jul 1;269(26):17734-40 PMID: 8021286
  300. Structural and functional studies on platelet-derived growth factor.
    EMBO J. 1992 Dec;11(12):4251-9 PMID: 1425569
  301. Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types.
    EMBO J. 1988 May;7(5):1387-93 PMID: 2842148
  302. Malignant transformation of NIH 3T3 fibroblasts by human c-sis is dependent upon the level of oncogene expression.
    Mol Carcinog. 1992;5(4):311-9 PMID: 1323300
  303. The expression of PDGF alpha- and beta-receptors in subpopulations of PDGF-producing cells implicates autocrine stimulatory loops in the control of proliferation in cytotrophoblasts that have invaded the maternal endometrium.
    Growth Factors. 1992;6(3):219-31 PMID: 1389228
  304. Growth factors and wound healing: platelet-derived growth factor as a model cytokine.
    Annu Rev Med. 1991;42:567-84 PMID: 2035994
  305. PDGF A-chain gene is expressed by mammalian neurons during development and in maturity.
    Cell. 1991 Jan 11;64(1):209-16 PMID: 1986867
  306. Selective expression of mRNA encoding platelet-derived growth factor B chain following transfection of foreign genes into cell lines derived from baby hamster kidney.
    J Cell Biochem. 1989 Jan;39(1):87-94 PMID: 2654148
  307. Platelet-derived growth factor in autocrine transformation.
    Cancer Res. 1991 Oct 1;51(19):5087-92 PMID: 1655243
  308. Production of platelet-derived growth factor-like molecules and reduced expression of platelet-derived growth factor receptors accompany transformation by a wide spectrum of agents.
    Proc Natl Acad Sci U S A. 1984 Apr;81(8):2396-400 PMID: 6326125
  309. The 5' untranslated sequence of the c-sis/platelet-derived growth factor 2 transcript is a potent translational inhibitor.
    Mol Cell Biol. 1988 Jan;8(1):284-92 PMID: 3275870
  310. H2O2 increases expression of pulmonary artery endothelial cell platelet-derived growth factor mRNA.
    J Appl Physiol (1985). 1992 Dec;73(6):2255-62 PMID: 1490932
  311. Expression of the sis gene by endothelial cells in culture and in vivo.
    Proc Natl Acad Sci U S A. 1984 Nov;81(21):6772-4 PMID: 6208557
  312. Mechanism of regulation of PDGF-A chain gene expression by serum and TPA.
    Biochim Biophys Acta. 1995 Jan 25;1260(2):176-82 PMID: 7841194
  313. Expression of PDGF A-chain and beta-receptor genes during rat myoblast differentiation.
    J Cell Biol. 1990 May;110(5):1665-72 PMID: 1970826
  314. Identification of three types of PDGF-A chain gene transcripts in rabbit vascular smooth muscle and their regulated expression during development and by angiotensin II.
    Biochem Biophys Res Commun. 1992 Apr 30;184(2):811-8 PMID: 1575749
  315. Expression of growth factor ligand and receptor genes in the preimplantation bovine embryo.
    Mol Reprod Dev. 1992 Feb;31(2):87-95 PMID: 1318055
  316. DNase-I-hypersensitive sites located far upstream of the human c-sis/PDGF-B gene comap with transcriptional enhancers and a silencer and are preceded by (part of) a new transcription unit.
    Eur J Biochem. 1993 Sep 1;216(2):487-95 PMID: 8375387
  317. Possible positive autocrine feedback in the prereplicative phase of human fibroblasts.
    Nature. 1987 Aug 20-26;328(6132):715-7 PMID: 3497351
  318. A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro.
    Proc Natl Acad Sci U S A. 1974 Apr;71(4):1207-10 PMID: 4208546
  319. Identification of mRNA for PDGF B-chain in human megakaryocytes isolated using a novel immunomagnetic separation method.
    Br J Haematol. 1990 Nov;76(3):333-9 PMID: 2261343
  320. Alternative RNA splicing affects function of encoded platelet-derived growth factor A chain.
    Nature. 1987 Aug 13-19;328(6131):621-4 PMID: 3614364
  321. Growth factor expression during rat development: a comparison of TGF-beta 3, TGF-alpha, bFGF, PDGF and PDGF-R.
    Int J Exp Pathol. 1993 Feb;74(1):87-96 PMID: 8471538
  322. Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells.
    Proc Natl Acad Sci U S A. 1995 May 9;92(10):4606-10 PMID: 7538678
  323. Cultured primate aortic smooth muscle cells express both the PDGF-A and PDGF-B genes but do not secrete mitogenic activity or dimeric platelet-derived growth factor protein.
    J Cell Physiol. 1988 Sep;136(3):479-85 PMID: 2459135
  324. 3-Deazaadenosine inhibits thrombin-stimulated platelet-derived growth factor production and endothelial-leukocyte adhesion molecule-1-mediated monocytic cell adhesion in human aortic endothelial cells.
    J Biol Chem. 1992 May 5;267(13):9376-82 PMID: 1374393
  325. Platelet-derived growth factor ligands and receptors immunolocalized in proliferative retinal diseases.
    Invest Ophthalmol Vis Sci. 1994 Sep;35(10):3649-63 PMID: 8088954
  326. Expression of growth factor and epidermal growth factor receptor encoded transcripts in human gastric tissues.
    Cancer Res. 1989 Apr 15;49(8):2104-11 PMID: 2702651
  327. Mechanical strain induces growth of vascular smooth muscle cells via autocrine action of PDGF.
    J Cell Biol. 1993 Nov;123(3):741-7 PMID: 8227136
  328. Shear stress increases endothelial platelet-derived growth factor mRNA levels.
    Am J Physiol. 1991 Feb;260(2 Pt 2):H642-6 PMID: 1996708
  329. A nuclear protein in mesangial cells that binds to the promoter region of the platelet-derived growth factor-A chain gene. Induction by phorbol ester.
    J Biol Chem. 1995 Mar 10;270(10):5541-8 PMID: 7890673
  330. Transforming growth factor-beta induces platelet-derived growth factor (PDGF) messenger RNA and PDGF secretion while inhibiting growth in normal human mammary epithelial cells.
    Mol Endocrinol. 1990 Jul;4(7):981-9 PMID: 2178225
  331. Control of the expression of c-sis mRNA in human glioblastoma cells by phorbol ester and transforming growth factor beta 1.
    Cancer Res. 1989 Jun 1;49(11):2914-20 PMID: 2655888
  332. A common PDGF receptor is activated by homodimeric A and B forms of PDGF.
    Science. 1988 Jun 10;240(4858):1532-4 PMID: 2836953
  333. Autoinduction of platelet derived growth factor (PDGF) A-chain mRNA expression in a human malignant melanoma cell line and growth inhibitory effects of PDGF-A-chain mRNA-specific antisense molecules.
    Biochem Biophys Res Commun. 1993 Jun 15;193(2):744-51 PMID: 8512572
  334. Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops.
    Cancer Res. 1992 Jun 1;52(11):3213-9 PMID: 1317261
  335. Neuroblastoma cells express c-sis and produce a transforming growth factor antigenically related to the platelet-derived growth factor.
    Mol Cell Biol. 1985 Sep;5(9):2289-97 PMID: 2874480
  336. Rat skeletal myoblasts and arterial smooth muscle cells express the gene for the A chain but not the gene for the B chain (c-sis) of platelet-derived growth factor (PDGF) and produce a PDGF-like protein.
    Proc Natl Acad Sci U S A. 1986 Sep;83(18):6844-8 PMID: 3462731
  337. sis (platelet-derived growth factor B chain) gene transcript levels are elevated in human atherosclerotic lesions compared to normal artery.
    Proc Natl Acad Sci U S A. 1987 Feb;84(4):1099-103 PMID: 2434949
  338. Induced differentiation of K562 leukemia cells: a model for studies of gene expression in early megakaryoblasts.
    Leuk Res. 1990;14(6):501-14 PMID: 2197510
  339. Splicing of the platelet-derived-growth-factor A-chain mRNA in human malignant mesothelioma cell lines and regulation of its expression.
    Eur J Biochem. 1992 Sep 15;208(3):589-96 PMID: 1396665
  340. Migratory and proliferative effect of platelet-derived growth factor in rabbit retinal endothelial cells: evidence of an autocrine pathway of platelet-derived growth factor.
    J Cell Physiol. 1994 Jan;158(1):1-6 PMID: 7505273
  341. Platelet-derived growth factor A chain is maternally encoded in Xenopus embryos.
    Science. 1988 Sep 2;241(4870):1223-5 PMID: 3413486
  342. The alternatively spliced exon of the platelet-derived growth factor A chain encodes a nuclear targeting signal.
    Mol Cell Biol. 1989 May;9(5):2251-3 PMID: 2747650
  343. Purification of PDGF-AB and PDGF-BB from human platelet extracts and identification of all three PDGF dimers in human platelets.
    Biochemistry. 1990 Jan 9;29(1):166-72 PMID: 2322537
  344. Expression of messenger RNAs for platelet-derived growth factor and its receptors in human sarcoma cell lines.
    Int J Cancer. 1990 Dec 15;46(6):1066-70 PMID: 2174413
  345. Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor beta: a proposed model for indirect mitogenesis involving autocrine activity.
    Proc Natl Acad Sci U S A. 1986 Apr;83(8):2453-7 PMID: 3010310
  346. PDGF-AA and PDGF-BB biosynthesis: proprotein processing in the Golgi complex and lysosomal degradation of PDGF-BB retained intracellularly.
    J Cell Biol. 1992 Aug;118(3):509-19 PMID: 1639841
  347. PKC alpha regulates thrombin-induced PDGF-B chain gene expression in mesangial cells.
    FEBS Lett. 1995 Oct 9;373(2):146-50 PMID: 7589454
  348. An S1 nuclease-sensitive homopurine/homopyrimidine domain in the PDGF A-chain promoter contains a novel binding site for the growth factor-inducible protein EGR-1.
    Biochem Biophys Res Commun. 1992 Oct 15;188(1):433-9 PMID: 1417865
  349. Tumor necrosis factor-mediated release of platelet-derived growth factor from cultured endothelial cells.
    J Exp Med. 1987 Jul 1;166(1):235-45 PMID: 3598461
  350. Altered regulation of platelet-derived growth factor A-chain and c-fos gene expression in senescent progeria fibroblasts.
    J Cell Physiol. 1990 Aug;144(2):313-25 PMID: 2166059
  351. A platelet-derived growth factor analog produced by a human clonal glioma cell line.
    Ann N Y Acad Sci. 1982 Dec 10;397:25-33 PMID: 6961845
  352. Modulation of transcription of the platelet-derived growth factor A-chain gene by a promoter region sensitive to S1 nuclease.
    J Biol Chem. 1992 Aug 25;267(24):17022-31 PMID: 1512241
  353. Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms tumor suppressor WT1.
    Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10984-8 PMID: 1332065
  354. Constitutive production of platelet-derived growth factor-like proteins by human prostate carcinoma cell lines.
    Cancer Res. 1988 Apr 1;48(7):1930-5 PMID: 2832055
  355. Role of platelet-derived growth factor in wound healing.
    J Cell Biochem. 1991 Apr;45(4):319-26 PMID: 2045423
  356. Kidney epithelial cells express c-sis protooncogene and secrete PDGF-like protein.
    Am J Physiol. 1988 Oct;255(4 Pt 2):F800-6 PMID: 3177660
  357. Aberrant oncogene expression in uncultured human sarcoma and melanoma.
    Anticancer Res. 1987 Nov-Dec;7(6):1117-23 PMID: 3442409
  358. Chromosomal localization of the human homolog (c-sis) of the simian sarcoma virus onc gene.
    Science. 1982 Nov 12;218(4573):686-8 PMID: 6291150
  359. Malignant epithelial cells in primary human lung carcinomas coexpress in vivo platelet-derived growth factor (PDGF) and PDGF receptor mRNAs and their protein products.
    Proc Natl Acad Sci U S A. 1992 May 1;89(9):3942-6 PMID: 1315044
  360. Frequent expression of growth factors for mesenchymal cells in human mammary carcinoma cell lines.
    Cancer Res. 1987 Jul 1;47(13):3425-9 PMID: 3034415
  361. Autocrine control of human meningioma proliferation: secretion of platelet-derived growth-factor-like molecules.
    Int J Cancer. 1991 Sep 30;49(3):398-402 PMID: 1917138
  362. Evidence of autocrine regulation in human hepatoma cell lines.
    Biochem Biophys Res Commun. 1988 May 31;153(1):39-45 PMID: 2837209
  363. Uric acid stimulates vascular smooth muscle cell proliferation by increasing platelet-derived growth factor A-chain expression.
    J Biol Chem. 1991 May 5;266(13):8604-8 PMID: 2022672
  364. Induction of platelet-derived growth factor B/c-sis by the v-erbA oncogene in glial cells.
    Oncogene. 1995 Mar 16;10(6):1103-10 PMID: 7700635
  365. Increased platelet-derived growth factor A-chain expression in human uterine smooth muscle cells during the physiologic hypertrophy of pregnancy.
    Proc Natl Acad Sci U S A. 1990 Mar;87(6):2177-81 PMID: 2315311
  366. Wound macrophages express TGF-alpha and other growth factors in vivo: analysis by mRNA phenotyping.
    Science. 1988 Aug 5;241(4866):708-12 PMID: 3041594
  367. The half-lives of platelet-derived growth factor A- and B-chain mRNAs are similar in endothelial cells and unaffected by heparin-binding growth factor-1 or cycloheximide.
    J Cell Physiol. 1991 Apr;147(1):121-7 PMID: 1709940
  368. Stimulation of DNA synthesis in cultured primary human mesothelial cells by specific growth factors.
    FASEB J. 1988 Aug;2(11):2717-21 PMID: 3260881
  369. The Wilms' tumor gene product, WT1, represses transcription of the platelet-derived growth factor A-chain gene.
    J Biol Chem. 1992 Nov 5;267(31):21999-2002 PMID: 1429549
  370. Site-specific methylation inhibits transcriptional activity of platelet-derived growth factor A-chain promoter.
    J Biol Chem. 1993 Aug 15;268(23):17334-40 PMID: 8349616
  371. PDGF and its receptors in the developing rodent retina and optic nerve.
    Development. 1993 Jun;118(2):539-52 PMID: 8223278
  372. Ultrastructural localization of platelet-derived growth factor and related factors in normal and transformed cells.
    Exp Cell Res. 1988 Oct;178(2):479-92 PMID: 3139433
  373. Identification of a single-stranded DNA-binding protein that interacts with an S1 nuclease-sensitive region in the platelet-derived growth factor A-chain gene promoter.
    J Biol Chem. 1993 May 15;268(14):10681-5 PMID: 8486717
Article Info
Journal
Molecular biology reports
Abbr.
Mol Biol Rep
ISSN
0301-4851
DOI
10.1007/BF00996300
Published
1995-00-00
Pages
1-24
Language
English
Region
Netherlands
NLM ID
0403234
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00996300 View journal details
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