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PMID: 6594688 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Expression of cellular oncogenes during embryonic and fetal development of the mouse.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 81 ·No. 22 ·1984-11-00 ·Pages 7141-5

Slamon DJ, Cline MJ

Abstract

Cellular oncogenes are conserved with great fidelity across a broad span of evolution. This avid conservation suggests possible roles in critical physiologic functions. Little, however, is known about their activity in normal cellular processes. In this study, we examined the expression pattern of eight cellular oncogenes during embryonic and fetal development of the mouse. Five of these genes (c-myc, c-erb, c-Ha-ras, c-src, and c-sis) were expressed at appreciable levels, and four were modulated in a consistent manner during the course of prenatal development.

MeSH Terms
Age Factors Animals Gene Expression Regulation Mice/embryology,genetics,growth & development Oncogenes RNA, Messenger/genetics
Chemicals
RNA, Messenger
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Slamon D J
Cline M J
References (50)
50 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.81.22.7141
Published
1984-11-00
Pages
7141-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC392093
Subset
IM
Grants
NCI NIH HHS · CA 15619 · United States
NCI NIH HHS · CA 36827 · United States
External Links
PubMed source DOI: 10.1073/pnas.81.22.7141 PMC Full Text View journal details
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