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PMID: 8386263 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The adenovirus E1A-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33cdk2.

Journal of virology ·Vol. 67 ·No. 5 ·1993-05-00 ·Pages 2456-65

Faha B, Harlow E, Lees E

Abstract

The adenovirus E1A oncoproteins form stable complexes with several cellular proteins. Association of E1A with these proteins has been shown to be important for the oncogenic potential of E1A. Several of these proteins have been identified and include the product of the retinoblastoma gene and a key cell cycle regulatory protein, cyclin A. E1A also associates with a potent histone H1 kinase. The two major components of this activity are the cyclin E-p33cdk2 and cyclin A-p33cdk2 complexes. Both the cyclin E-p33cdk2 and cyclin A-p33cdk2 complexes have been implicated in regulatory events controlling entry into or passage through DNA synthesis. Although the architecture of such interactions remains unclear, it is likely that by targeting such complexes, adenovirus is affecting some aspect of cell cycle control.

MeSH Terms
Adenovirus E1A Proteins/metabolism Adenoviruses, Human/enzymology Cell Cycle/physiology Cells, Cultured Cyclins/metabolism Humans Protamine Kinase/metabolism Protein Serine-Threonine Kinases/metabolism
Chemicals
Adenovirus E1A Proteins Cyclins Protamine Kinase Protein Serine-Threonine Kinases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Faha B
Massachusetts General Hospital Cancer Center, Charlestown 02129.
Harlow E
Lees E
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.67.5.2456-2465.1993
Published
1993-05-00
Pages
2456-65
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC237564
Subset
IM
Grants
NCI NIH HHS · CA55339 · United States
External Links
PubMed source DOI: 10.1128/JVI.67.5.2456-2465.1993 PMC Full Text View journal details
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