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PMID: 1639063 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A family of human cdc2-related protein kinases.

The EMBO journal ·Vol. 11 ·No. 8 ·1992-08-00 ·Pages 2909-17

Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH

Abstract

The p34cdc2 protein kinase is known to regulate important transitions in the eukaryotic cell cycle. We have identified 10 human protein kinases based on their structural relation to p34cdc2. Seven of these kinases are novel and the products of five share greater than 50% amino acid sequence identity with p34cdc2. The seven novel genes are broadly expressed in human cell lines and tissues with each displaying some cell type or tissue specificity. The cdk3 gene, like cdc2 and cdk2, can complement cdc28 mutants of Saccharomyces cerevisiae, suggesting that all three of these protein kinases can play roles in the regulation of the mammalian cell cycle. The identification of a large family of cdc2-related kinases opens the possibility of combinatorial regulation of the cell cycle together with the emerging large family of cyclins.

Related Genes
cdc2 cdc28 cdk2 cdk3
MeSH Terms
Amino Acid Sequence CDC2 Protein Kinase/genetics Cell Cycle Cell Line Cloning, Molecular DNA, Neoplasm/genetics,isolation & purification Genetic Complementation Test HeLa Cells Humans Molecular Sequence Data Multigene Family RNA, Neoplasm/genetics,isolation & purification Saccharomyces cerevisiae/enzymology,genetics Sequence Homology, Nucleic Acid
Chemicals
DNA, Neoplasm RNA, Neoplasm CDC2 Protein Kinase
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Meyerson M
Massachusetts General Hospital Cancer Center, Charlestown 02129.
Enders G H
Wu C L
Su L K
Gorka C
Nelson C
Harlow E
Tsai L H
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1992-08-00
Pages
2909-17
Language
English
Region
England
NLM ID
8208664
PMCID
PMC556772
Subset
IM
Databases
GENBANK
L02121, X66357, X66358, X66359, X66360, X66361, X66362, X66363, X66364, X66365
External Links
PubMed source PMC Full Text View journal details
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