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PMID: 6308473 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture.

Nature ·Vol. 304 ·No. 5927 ·1983-00-00 ·Pages 602-6

Ruley HE

Abstract

The polyoma virus middle-T and the T24 Harvey ras1 genes are individually unable to transform primary baby rat kidney cells. Adenovirus early region 1A provides functions required by these genes to transform primary cells following DNA-mediated gene transfer. These results suggest that separate establishment and transforming functions are required for oncogenic transformation of primary cells in culture.

MeSH Terms

Adenoviridae/genetics Animals Antigens, Viral/genetics Antigens, Viral, Tumor Cell Transformation, Viral Cells, Cultured Cloning, Molecular Gene Expression Regulation Genes, Viral Oncogenes Plasmids Polyomavirus/genetics Rats Transfection Transformation, Genetic

Chemicals

Antigens, Viral Antigens, Viral, Tumor

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Ruley H E

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/304602a0

Published

1983-00-00

Pages

602-6

Language

English

Region

England

NLM ID

0410462

Subset

Grants

NCI NIH HHS · CA13106 · United States

External Links

PubMed source DOI: 10.1038/304602a0 View journal details

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Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture.

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