E2F: a link between the Rb tumor suppressor protein and viral oncoproteins.

Science (New York, N.Y.) ·Vol. 258 ·No. 5081 ·1992-10-16 ·Pages 424-9

Nevins JR

Abstract

The cellular transcription factor E2F, previously identified as a component of early adenovirus transcription, has now been shown to be important in cell proliferation control. E2F appears to be a functional target for the action of the tumor suppressor protein Rb that is encoded by the retinoblastoma susceptibility gene. The disruption of this E2F-Rb interaction, as well as a complex involving E2F in association with the cell cycle-regulated cyclin A-cdk2 kinase complex, may be a common mechanism of action for the oncoproteins encoded by the DNA tumor viruses.

Related Genes

E1A RB1 RB3 RBAP1

MeSH Terms

Adenovirus E1A Proteins/metabolism Adenoviruses, Human/genetics Binding Sites Carrier Proteins Cell Cycle Cell Cycle Proteins Cell Transformation, Viral Cloning, Molecular DNA-Binding Proteins/metabolism E2F Transcription Factors Gene Expression Regulation, Viral Genes, Tumor Suppressor Humans Oncogene Proteins, Viral/metabolism Protein Binding Regulatory Sequences, Nucleic Acid Retinoblastoma Protein/metabolism Retinoblastoma-Binding Protein 1 Transcription Factor DP1 Transcription Factors/metabolism

Chemicals

Adenovirus E1A Proteins Carrier Proteins Cell Cycle Proteins DNA-Binding Proteins E2F Transcription Factors Oncogene Proteins, Viral Retinoblastoma Protein Retinoblastoma-Binding Protein 1 Transcription Factor DP1 Transcription Factors

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Nevins J R

Howard Hughes Medical Institute, Section of Genetics, Duke University Medical Center, Durham, NC 27710.

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.1411535

Published

1992-10-16

Pages

424-9

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.1411535 View journal details

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E2F: a link between the Rb tumor suppressor protein and viral oncoproteins.

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