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PMID: 8179845 Published · ppublish English Comparative Study Journal Article Review

Structure, function and expression of voltage-dependent sodium channels.

Molecular neurobiology ·Vol. 7 ·No. 3-4 ·1993-00-00 ·Pages 383-428

Kallen RG, Cohen SA, Barchi RL

Abstract

Voltage-dependent sodium channels control the transient inward current responsible for the action potential in most excitable cells. Members of this multigene family have been cloned, sequenced, and functionally expressed from various tissues and species, and common features of their structure have clearly emerged. Site-directed mutagenesis coupled with in vitro expression has provided additional insight into the relationship between structure and function. Subtle differences between sodium channel isoforms are also important, and aspects of the regulation of sodium channel gene expression and the modulation of channel function are becoming topics of increasing importance. Finally, sodium channel mutations have been directly linked to human disease, yielding insight into both disease pathophysiology and normal channel function. After a brief discussion of previous work, this review will focus on recent advances in each of these areas.

Related Genes
SCN2A SCN4A ras
MeSH Terms
Action Potentials Amino Acid Sequence Animals Brain Chemistry Chromosome Mapping Cyclic AMP-Dependent Protein Kinases/physiology Gene Expression Regulation Heart/physiology Ion Channel Gating/physiology Kinetics Models, Molecular Molecular Sequence Data Muscle Proteins/chemistry,drug effects,physiology Mutagenesis Nerve Tissue Proteins/chemistry,drug effects,physiology Neuromuscular Diseases/physiopathology Neurotoxins/pharmacology Phosphorylation Protein Conformation Protein Processing, Post-Translational Protein Structure, Tertiary Rats Recombinant Fusion Proteins/physiology Sequence Alignment Sequence Homology, Amino Acid Sodium Channels/chemistry,drug effects,physiology
Chemicals
Muscle Proteins Nerve Tissue Proteins Neurotoxins Recombinant Fusion Proteins Sodium Channels Cyclic AMP-Dependent Protein Kinases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kallen R G
Mahoney Institute of Neurological Sciences, University of Pennsylvania School of Medicine, Philadelphia.
Cohen S A
Barchi R L
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Article Info
Journal
Molecular neurobiology
Abbr.
Mol Neurobiol
ISSN
0893-7648
DOI
10.1007/BF02769184
Published
1993-00-00
Pages
383-428
Language
English
Region
United States
NLM ID
8900963
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02769184 View journal details
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