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PMID: 2571571 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Localization of a human brain sodium channel gene (SCN2A) to chromosome 2.

Genomics ·Vol. 5 ·No. 2 ·1989-08-00 ·Pages 204-8

Litt M, Luty J, Kwak M, Allen L, Magenis RE, Mandel G

Abstract

A DNA probe derived from a human genomic library has been used to localize on human chromosomes a gene coding for the alpha-subunit of the brain type II sodium channel (SCN2A). Hybridization of the probe to Southern blots made with DNAs from a rodent-human somatic cell hybrid panel indicates localization to the long arm of human chromosome 2. In situ hybridization to metaphase chromosomes confirms this assignment and indicates regional localization to 2q21-q33. The probe also reveals a frequent two-allele HaeIII RFLP.

MeSH Terms

Animals Blotting, Southern Chromosome Banding Chromosome Mapping Chromosomes, Human, Pair 2/ultrastructure Cricetinae DNA Probes Humans Hybrid Cells Male Mice Polymorphism, Restriction Fragment Length Restriction Mapping Sodium Channels

Chemicals

DNA Probes Sodium Channels

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Litt M

Department of Biochemistry, Oregon Health Sciences University, Portland 97201.

Luty J

Kwak M

Allen L

Magenis R E

Mandel G

Article Info

Journal

Genomics

Abbr.

Genomics

ISSN

0888-7543

DOI

10.1016/0888-7543(89)90047-5

Published

1989-08-00

Pages

204-8

Language

English

Region

United States

NLM ID

8800135

Subset

Grants

NIGMS NIH HHS · R01-GM32500 · United States

NINDS NIH HHS · R01-NS22518 · United States

External Links

PubMed source DOI: 10.1016/0888-7543(89)90047-5 View journal details

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Localization of a human brain sodium channel gene (SCN2A) to chromosome 2.

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