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PMID: 7924617 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

Telomeric repeat sequences.

Chromosoma ·Vol. 103 ·No. 3 ·1994-06-00 ·Pages 154-61

Biessmann H, Mason JM

Abstract

Chromosomes not only carry transcribed genes and their regulatory DNA sequences, but also contain regions that are required for the stability and maintenance of the chromosome as a unit. These include centromeres, telomeres and origins of replication. It is clear for replication origins and centromeres that the positions of these chromosomal organelles are determined by sites of the appropriate DNA sequences, but also that functional performance requires one or more contributing proteins. Telomeres are also structurally complex, with one or more DNA components, including simple telomeric repeats and more complex telomere-associated sequences, as well as one or more specific proteins that recognize these sequences. Accumulating evidence suggests that the simple telomeric repeats are required in most, but not all species, although they are not sufficient to determine the chromosomal position of a telomere.

MeSH Terms
Animals Humans Models, Genetic Repetitive Sequences, Nucleic Acid/physiology Telomere/physiology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Biessmann H
Developmental Biology Center, University of California, Irvine 92717.
Mason J M
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Article Info
Journal
Chromosoma
Abbr.
Chromosoma
ISSN
0009-5915
DOI
10.1007/BF00368007
Published
1994-06-00
Pages
154-61
Language
English
Region
Austria
NLM ID
2985138R
Subset
IM
Grants
NIGMS NIH HHS · GM46211 · United States
External Links
PubMed source DOI: 10.1007/BF00368007 View journal details
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