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PMID: 6834468 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Sequential mutations in the NS genes of influenza virus field strains.

Journal of virology ·Vol. 45 ·No. 2 ·1983-02-00 ·Pages 547-54

Krystal M, Buonagurio D, Young JF, Palese P

Abstract

The complete nucleotide sequences of the NS genes from three human influenza viruses, A/FM/1/47 (H1N1), A/FW/1/50 (H1N1), and A/USSR/90/77 (H1N1), were determined. Only five single-base differences were found within the sequences of the A/FW/1/50 and A/USSR/90/77 NS genes, thus confirming earlier data suggesting that the 1977 H1N1 viruses are closely related to virus strains that were circulating around 1950. Comparison of all three sequences with those from A/PR/8/34 and A/Udorn/72 viruses illustrates that these genes (with the exception of that of the A/USSR/90/77 strain) evolve through cumulative base changes along a single common lineage. A nucleotide sequence variation of approximately 2.2 to 3.4% per 10 years was determined for the NS gene segments. Extensive size variation was also observed among the NS1 proteins of the various human viruses. The A/FM/1/47 NS1 protein, which consists of 202 amino acids, is 15% shorter than the A/Udorn/72 NS1 protein, which consists of 237 amino acids.

MeSH Terms
Amino Acid Sequence Base Sequence DNA, Recombinant Genes, Viral Influenza A virus/genetics Mutation Phylogeny
Chemicals
DNA, Recombinant
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Krystal M
Buonagurio D
Young J F
Palese P
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44 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.45.2.547-554.1983
Published
1983-02-00
Pages
547-54
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC256448
Subset
IM
Grants
NIAID NIH HHS · AI-11823 · United States
NIAID NIH HHS · AI-18998 · United States
Databases
GENBANK
K00576, K00577, K00578
External Links
PubMed source DOI: 10.1128/JVI.45.2.547-554.1983 PMC Full Text View journal details
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