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PMID: 6785204 Published · ppublish English Journal Article

Sister chromatid exchanges and heterochromatin.

Human genetics ·Vol. 57 ·No. 2 ·1981-00-00 ·Pages 119-30

Schubert I, Rieger R

Abstract

The inter- and intrachromosomal distribution patterns of SCEs obtained with or without mutagen treatment are reviewed and compared, with each other as to their relation to heterochromatin and with the distribution patterns of chromatid aberrations that occurred either "spontaneously" in chromosomes of repair-defective human syndromes or after treatment with the mutagens (BrdU, ethylalcohol, DMBA, TMBA, maleic hydrazide, MMS, MMC). The conclusions are: No general rule is detectable for nonrandom involvement of heterochromatin in spontaneous SCEs. Mutagen-induced SCEs show the same or very similar distribution patterns as the spontaneous ones and are in no case as preferentially located as chromatid aberrations (which involve mainly the junctions between eu- and heterochromatin or other special regions). Therefore, a specific mutagen sensitivity of heterochromatin-aberrations does not exist (or is less pronounced) for SCEs. This supports the inference that different mechanisms underlie the origins of the two phenomena.

MeSH Terms
Animals Artiodactyla/genetics Arvicolinae/genetics Chromosome Aberrations Cricetinae Cricetulus/genetics Crossing Over, Genetic Drosophila melanogaster/genetics Heterochromatin/physiology Humans Male Marsupialia/genetics Mutation Plants/genetics Rats Rodentia/genetics Sister Chromatid Exchange
Chemicals
Heterochromatin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Schubert I
Rieger R
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51 references, click to expand
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00282006
Published
1981-00-00
Pages
119-30
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00282006 View journal details
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