Sister chromatid exchanges and chromatid interchanges in bloom's syndrome.

Humangenetik ·Vol. 30 ·No. 4 ·1975-12-23 ·Pages 317-23

Schroeder TM

Abstract

A comparison is made between the incidences of sister chromatid exchanges (SCE) per chromosome and group of chromosomes and breakage, visible at metaphase like open gaps, breaks, and breaks involved in chromatid interchange formation (CI) in Bloom's syndrome. It can be shown that the two levels of breakage SCE and CI are not correlated as to the locations. The discussion deals with possible interpretations of preferential breakage and reunion at certain homologous chromosomes and the difficulties today to understand SCEs.

MeSH Terms

Chromosome Aberrations Crossing Over, Genetic Facial Dermatoses/genetics Heterozygote Homozygote Humans Male Recombination, Genetic Syndrome Telangiectasis/genetics

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Schroeder T M

References (10)

10 references, click to expand

Induction of sister chromatid exchanges by UV light and its inhibition by caffeine.
Exp Cell Res. 1973 Dec;82(2):383-90 PMID: 4797252
Localization of sister chromatid exchanges in human chromosomes.
Science. 1974 Jul 5;185(4145):74-6 PMID: 4134970
The internal order of the interphase nucleus.
Humangenetik. 1974;25(4):265-97 PMID: 4464236
Induction of sister chromatid exchanges by chemical mutagens and its possible relevance to DNA repair.
Exp Cell Res. 1974 Apr;85(2):239-47 PMID: 4857154
The human leukocyte test system. VI. The use of sister chromatid exchanges as possible indicators for mutagenic activities.
Humangenetik. 1975 Sep 10;29(2):127-34 PMID: 1176134
The rate of sister chromatid exchanges parallel to spontaneous chromosome breakage in Fanconi's anemia and to trenimon-induced aberrations in human lymphocytes and fibroblasts.
Humangenetik. 1975 Sep 23;29(3):201-6 PMID: 1165100
Implications of somatic recombination and sister chromatid exchange in Bloom's syndrome and cells treated with mitomycin C.
Humangenetik. 1975 Jul 23;28(3):191-6 PMID: 1150278
Bloom's syndrome and Fanconi's anemia: demonstration of two distinctive patterns of chromosome disruption and rearrangement.
Humangenetik. 1974;25(4):299-306 PMID: 4464237
A retarded rate of DNA chain growth in Bloom's syndrome.
Proc Natl Acad Sci U S A. 1975 Feb;72(2):758-62 PMID: 1054854
A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes.
Proc Natl Acad Sci U S A. 1974 Nov;71(11):4508-12 PMID: 4140506

Article Info

Journal

Humangenetik

Abbr.

Humangenetik

ISSN

0018-7348

DOI

10.1007/BF00275144

Published

1975-12-23

Pages

317-23

Language

English

Region

Germany

NLM ID

7607154

Subset

External Links

PubMed source DOI: 10.1007/BF00275144

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