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PMID: 976010 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Study of mitomycin C-induced chromosomal exchange.

Chromosoma ·Vol. 56 ·No. 1 ·1976-06-30 ·Pages 1-13

Huttner KM, Ruddle FH

Abstract

Mitomycin C-induced sister chromatic exchange and quadriradial formation were studied in chromosomes from Muntiacus muntjac fibroblasts and A9, a transformed mouse cell line. We present the first direct cytological evidence for the induction of true somatic recombination involving homologous chromosomes. Analysis of the quadriradials from Muntjac cells indicates a non-random distribution with respect to the chromosomes involved and with respect to the points of conjunction. Sister chromatid exchange and quadriradial formation may reflect the outcome of repair processes involving a high frequency of homologous exchanges in the interphase nucleus.

MeSH Terms
Animals Chromatids/drug effects Crossing Over, Genetic/drug effects DNA Repair Deer Mice Mitomycins/pharmacology Recombination, Genetic/drug effects
Chemicals
Mitomycins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Huttner K M
Ruddle F H
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20 references, click to expand
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Article Info
Journal
Chromosoma
Abbr.
Chromosoma
ISSN
0009-5915
DOI
10.1007/BF00293724
Published
1976-06-30
Pages
1-13
Language
English
Region
Austria
NLM ID
2985138R
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00293724 View journal details
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