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PMID: 50275 Published · ppublish English Journal Article

Frequency and distribution of sister-chromatid exchanges in a case of Fanconi's anemia.

Humangenetik ·Vol. 27 ·No. 3 ·1975-00-00 ·Pages 227-30

Sperling K, Wegner RD, Riehm H, Obe G

Abstract

In lymphocytes of a 7-year-old boy with Fanconi's anemia the frequencies and sites of sister-chromatid exchanges (SCE) were studied with the BrdU-Giemsa method. The average frequency of SCE (8.8 per metaphase) and the inter- and intrachromosomal distribution of SCE was not significantly different from the controls.

MeSH Terms
Anemia, Aplastic/genetics Benzimidazoles Chromatids Crossing Over, Genetic DNA Repair Fanconi Anemia/genetics Humans Karyotyping Lymphocytes/cytology Male Mitosis Staining and Labeling Syndrome
Chemicals
Benzimidazoles
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Sperling K
Wegner R D
Riehm H
Obe G
References (10)
10 references, click to expand
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    Science. 1974 Jul 5;185(4145):74-6 PMID: 4134970
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    Nature. 1974 Jul 19;250(463):223-5 PMID: 4851278
  7. Spatial distribution of old and new chromatid sub-units and frequency of chromatid exchanges in induced human lymphocyte endoreduplications.
    Nature. 1967 Oct 21;216(5112):286-8 PMID: 6057949
  8. A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes.
    Proc Natl Acad Sci U S A. 1974 Nov;71(11):4508-12 PMID: 4140506
  9. New Giemsa method for the differential staining of sister chromatids.
    Nature. 1974 Sep 13;251(5471):156-8 PMID: 4138930
  10. [Chromatid exchange and heterochromatin alteration of human chromosomes with BUdR-labelling. Demonstrated by benzimidazolfluorochrome and Giemsa stain].
    Humangenetik. 1974;25(3):179-88 PMID: 4141335
Article Info
Journal
Humangenetik
Abbr.
Humangenetik
ISSN
0018-7348
DOI
10.1007/BF00278349
Published
1975-00-00
Pages
227-30
Language
English
Region
Germany
NLM ID
7607154
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00278349
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