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PMID: 6378622 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A family of dispersed repetitive extragenic palindromic DNA sequences in E. coli.

The EMBO journal ·Vol. 3 ·No. 6 ·1984-06-00 ·Pages 1417-21

Gilson E, Clément JM, Brutlag D, Hofnung M

Abstract

We report the properties of 67 members of a family of dispersed repetitive palindromic extragenic bacterial DNA sequences. These sequences, called palindromic units, appear to be present at least several hundred times outside structural genes on the Escherichia coli chromosome. They are found either in clusters - as in a previously described intercistronic element - or in single occurrences. They are not only found within an operon but also between different operons, including between convergent ones. The palindromic units could yield a stem and loop structure at the level of DNA or RNA. The base of the stem is made of eight remarkably conserved base pairs while the rest varies somewhat in length and sequence. We analyse the data available on the palindromic units and we speculate on their possible roles with emphasis on transcription and mRNA stability or processing, as well as on their possible relation to transposition elements and the modular evolution of the genome.

MeSH Terms
Base Sequence Computers DNA, Bacterial/genetics Escherichia coli/genetics Genes, Bacterial Plasmids Probability
Chemicals
DNA, Bacterial
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Gilson E
Clément J M
Brutlag D
Hofnung M
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47 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1984-06-00
Pages
1417-21
Language
English
Region
England
NLM ID
8208664
PMCID
PMC557532
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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