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PMID: 6360043 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Indirect induction of SOS functions in Salmonella typhimurium.

Antonie van Leeuwenhoek ·Vol. 49 ·No. 4-5 ·1983-11-00 ·Pages 471-84

Barbé J, Villaverde A, Guerrero R

Abstract

Infection of non-UV-irradiated cells of Salmonella typhimurium with UV-damaged P22 or KB1 phage induces recA-dependent inhibition of cell division, cell mutagenesis and prophage induction but not inhibition of respiration. On the contrary, respiration and ATP concentration are increased after treatment with UV-damaged phage in both RecA+ and RecA- strains, showing that this increase is not recA-dependent. Furthermore, infection with UV-damaged phage prevents both inhibition of respiration and decrease in ATP level in the UV-irradiated RecA+ strain. This indirect induction of SOS functions is related to degradation of phage DNA as well as to the multiplicity of infection used, suggesting that DNA degradation may play an important role in the mechanism of expression of the SOS system. Our results give also support to the hypothesis that there exists a differentiation in the expression of the various SOS functions.

MeSH Terms
Salmonella Phages/physiology Salmonella typhimurium/genetics,physiology Virus Activation
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Barbé J
Villaverde A
Guerrero R
References (34)
34 references, click to expand
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Article Info
Journal
Antonie van Leeuwenhoek
Abbr.
Antonie Van Leeuwenhoek
ISSN
0003-6072
DOI
10.1007/BF00399325
Published
1983-11-00
Pages
471-84
Language
English
Region
Netherlands
NLM ID
0372625
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00399325 View journal details
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