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PMID: 211114 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Effects of antipain (a protease inhibitor) on respiration, viability, and excision of pyrimidine dimers in UV-irradiated Escherichia coli cells.

Journal of bacteriology ·Vol. 135 ·No. 3 ·1978-09-00 ·Pages 1167-70

Swenson PA, Schenley RL

Abstract

The protease inhibitor antipain increases the effectiveness of UV irradiation on cessation of respiration and cell killing in Escherichia coli B/r cultures without affecting excision of pyrimidine dimers. The actions are similar to those caused by cyclic AMP in irradiated cultures.

MeSH Terms

Cyclic AMP/pharmacology Escherichia coli/drug effects,growth & development,metabolism,radiation effects Protease Inhibitors/pharmacology Pyrimidine Dimers/metabolism Ultraviolet Rays

Chemicals

Protease Inhibitors Pyrimidine Dimers Cyclic AMP

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Swenson P A

Schenley R L

References (9)

9 references, click to expand

Role of cyclic adenosine 3',5'-monophosphate on cessation of respiration in ultraviolet-irradiated Escherichia coli.
J Bacteriol. 1977 Aug;131(2):707-9 PMID: 195931
Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli.
Bacteriol Rev. 1976 Dec;40(4):869-907 PMID: 795416
Regulation of cessation of respiration and killing by cyclic 3',5'-adenosine monophosphate and its receptor protein after far-ultraviolet irradiation of Escherichia coli.
Mol Gen Genet. 1978 Feb 16;159(2):125-30 PMID: 204860
Inactivation and proteolytic cleavage of phage lambda repressor in vitro in an ATP-dependent reaction.
Proc Natl Acad Sci U S A. 1977 Jun;74(6):2283-7 PMID: 329277
A protease inhibitor blocks SOS functions in Escherichia coli: antipain prevents lambda repressor inactivation, ultraviolet mutagenesis, and filamentous growth.
Proc Natl Acad Sci U S A. 1977 Mar;74(3):1152-6 PMID: 322145
Structure of antipain, a new Sakaguchi-positive product of streptomyces.
J Antibiot (Tokyo). 1972 Apr;25(4):267-70 PMID: 5052959
Evidence relating cessation of respiration, cell envelope changes, and death in ultraviolet-irradiated Escherichia coli B-r cells.
J Bacteriol. 1974 Feb;117(2):551-9 PMID: 4590476
Respiration, growth and viability of repair-deficient mutants of Escherichia coli after ultraviolet irradiation.
Int J Radiat Biol Relat Stud Phys Chem Med. 1974 Jan;25(1):51-60 PMID: 4588877
Centrifugal separation of irradiated cultures of Escherichia coli cells into viable and nonviable populations.
J Bacteriol. 1976 May;126(2):977-84 PMID: 770460

Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/jb.135.3.1167-1170.1978

Published

1978-09-00

Pages

1167-70

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC222500

Subset

External Links

PubMed source DOI: 10.1128/jb.135.3.1167-1170.1978 PMC Full Text View journal details

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Effects of antipain (a protease inhibitor) on respiration, viability, and excision of pyrimidine dimers in UV-irradiated Escherichia coli cells.

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