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PMID: 368796 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Escherichia coli recA gene product inactivates phage lambda repressor.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 75 ·No. 10 ·1978-10-00 ·Pages 4714-8

Roberts JW, Roberts CW, Craig NL

Abstract

Phage lambda repressor is inactivated and cleaved into two detectable fragments during incubation with purified Escherichia coli recA gene protein in vitro, in a reaction that requires ATP. This reaction reproduces the recA-dependent inactivation of repressor that occurs in vivo during induction of the SOS functions. The proteolytic activity may reside in the recA protein itself and may be a fundamental activity of it.

MeSH Terms
Adenosine Triphosphate/metabolism Bacterial Proteins/pharmacology Coliphages/genetics Escherichia coli/genetics Genes In Vitro Techniques Recombination, Genetic Repressor Proteins/antagonists & inhibitors Transcription Factors/antagonists & inhibitors Viral Proteins/antagonists & inhibitors
Chemicals
Bacterial Proteins Repressor Proteins Transcription Factors Viral Proteins Adenosine Triphosphate
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Roberts J W
Roberts C W
Craig N L
References (19)
19 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.75.10.4714
Published
1978-10-00
Pages
4714-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC336190
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.75.10.4714 PMC Full Text View journal details
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