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PMID: 6287001 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus.

Journal of virology ·Vol. 43 ·No. 1 ·1982-07-00 ·Pages 26-36

Jenkins NA, Copeland NG, Taylor BA, Lee BK

Abstract

The endogenous ecotropic murine leukemia virus DNA content and integration sites were characterized for 54 inbred strains and substrains of mice by restriction enzyme digestion, Southern blotting, and hybridization with an ecotropic murine leukemia virus DNA-specific probe. More than 75% of these strains carried endogenous ecotropic proviruses which were located in at least 29 distinct integration sites in chromosomes of Mus musculus. Fourteen of these proviruses have been assigned specific locus designations. Most, but not all, of the endogenous ecotropic proviruses were structurally indistinguishable by this analysis from the prototype AKR ecotropic virus, and the distribution of these proviruses followed known relationships among the inbred strains and substrains of mice. These results suggest that, in general, viral DNA integration preceded the establishment of inbred mouse strains and that these integrations are relatively stable.

MeSH Terms
Animals Base Sequence Chromosomes/analysis DNA Restriction Enzymes DNA, Viral Genes, Viral Leukemia Virus, Murine/genetics Mice Mice, Inbred Strains/genetics,microbiology Nucleic Acid Hybridization Recombination, Genetic
Chemicals
DNA, Viral DNA Restriction Enzymes
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Jenkins N A
Copeland N G
Taylor B A
Lee B K
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37 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.43.1.26-36.1982
Published
1982-07-00
Pages
26-36
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC256092
Subset
IM
Grants
NCI NIH HHS · N0 1 CP33255 · United States
External Links
PubMed source DOI: 10.1128/JVI.43.1.26-36.1982 PMC Full Text View journal details
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