Genetic mapping of a murine leukemia virus-inducing locus of AKR mice.

Science (New York, N.Y.) ·Vol. 178 ·No. 4063 ·1972-11-24 ·Pages 860-2

Rowe WP, Hartley JW, Bremner T

Abstract

The chromosomal location of one of the two murine leukemia virus-inducing loci of AKR mice has been determined. The locus, which appears to be the integrated genome of the virus, is designated Akv-1, and is on linkage group 1, 12 map units from Gpi-1, with gene order c-Gpi-1-Akv-1. This identification of a closely linked gene whose phenotype is independent of virus expression should facilitate analysis of the biologic importance of the Akv-1 locus.

MeSH Terms

Animals Chromosome Mapping Crosses, Genetic Female Genes Genetic Linkage Genotype Idoxuridine/pharmacology Leukemia Virus, Murine Leukemia, Experimental/genetics Male Mice Mice, Inbred AKR Neoplasms, Experimental/genetics Phenotype Virus Replication/drug effects

Chemicals

Idoxuridine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Rowe W P

Hartley J W

Bremner T

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.178.4063.860

Published

1972-11-24

Pages

860-2

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.178.4063.860 View journal details

Analysis Services

Genetic mapping of a murine leukemia virus-inducing locus of AKR mice.

Contact

WeChat Official Account