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PMID: 6255464 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Structure of endogenous murine leukemia virus DNA in mouse genomes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 77 ·No. 10 ·1980-10-00 ·Pages 5774-8

Chattopadhyay SK, Lander MR, Rands E, Lowy DR

Abstract

By using molecularly cloned ecotropic AKR murine leukemia virus (MuLV) DNA, a 400-base-pair ecotropic type-specific segment in the env region has been identified. This DNA segment and other defined viral subgenomic fragments have been used as 32P-labeled probes to identify and analyze the structure of integrated ecotropic viral DNA sequences in uninfected mouse genomes. Those mice from which endogenous ecotropic MuLV of the AKR type have been isolated contained at least one virtually complete linear copy of the viral genome. Strains from which ecotropic MuLV has not been isolated lacked ecotropic-specific sequences. All inbred mouse strains tested also contained MuLV DNAs of genomic length whose restriction endonuclease digestion pattern was characteristic of xenotropic viruses.

MeSH Terms
Animals Cells, Cultured DNA, Recombinant DNA, Viral/genetics Genes, Viral Leukemia Virus, Murine/genetics Mice/microbiology Nucleic Acid Hybridization Species Specificity Virus Replication
Chemicals
DNA, Recombinant DNA, Viral
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Chattopadhyay S K
Lander M R
Rands E
Lowy D R
References (30)
30 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.77.10.5774
Published
1980-10-00
Pages
5774-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC350153
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.77.10.5774 PMC Full Text View journal details
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