Home LiteratureArticle Details
PMID: 6174854 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Effects of sodium butyrate, a new pharmacological agent, on cells in culture.

Molecular and cellular biochemistry ·Vol. 42 ·No. 2 ·1982-02-05 ·Pages 65-82

Kruh J

Abstract

Sodium butyrate, at millimolar concentrations, when added to cell cultures produces many morphological and biochemical modifications in a reversible manner. Some of them occur in all cell lines. They concern regulatory mechanisms of gene expression and cell growth: an hyperacetylation of histone resulting from an inhibition of histone deacetylase and an arrest of cell proliferation are almost constantly observed. Some other modifications vary from one cell type to another: induction of proteins, including enzymes, hormones, hemoglobin, inhibition of cell differentiation, reversion of transformed characteristics of cells to normal morphological and biochemical pattern, increase in interferon antiviral efficiency and induction of integrated viruses. Most if not all these effects of butyrate could result from histone hyperacetylation, from changes in chromatin structures as measured by accessibility to DNases and from modifications in cytoskeleton assembly. We do not know at the present time whether butyrate acts on a very specific target site in cell or if it acts on several cell components.

MeSH Terms
Acetylation Animals Butyrates/pharmacology Cell Cycle/drug effects Cell Differentiation/drug effects Cell Division/drug effects Cell Nucleus/drug effects Cell Transformation, Neoplastic/drug effects Cell Transformation, Viral/drug effects Cells, Cultured/drug effects Chromatin/drug effects Chromosomal Proteins, Non-Histone/metabolism Cricetinae Cytoplasmic Granules/drug effects Enzyme Induction/drug effects Fibronectins/metabolism Gene Expression Regulation Histone Deacetylase Inhibitors Histones/metabolism Hormones/metabolism Humans Interferons/metabolism Mice Microtubules/drug effects Protein Biosynthesis Virus Activation/drug effects Virus Replication/drug effects
Chemicals
Butyrates Chromatin Chromosomal Proteins, Non-Histone Fibronectins Histone Deacetylase Inhibitors Histones Hormones Interferons
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kruh J
References (119)
119 references, click to expand
  1. Induction of human choriogonadotropin in heLa-cell cultures by aliphatic monocarboxylates and inhibitors of deoxyribonucleic acid synthesis.
    Biochem J. 1977 Aug 15;166(2):265-74 PMID: 911320
  2. Modification of histone binding in calf thymus chromatin and in the chromatin-protamine complex by acetic anhydride.
    Biochemistry. 1976 May 18;15(10):2041-6 PMID: 1276123
  3. Studies on highly metabolically active acetylation and phosphorylation of histones.
    J Biol Chem. 1975 Jul 10;250(13):4856-63 PMID: 168194
  4. Effect of sodium butyrate on myoblast growth and differentiation.
    Biochem Biophys Res Commun. 1979 Apr 13;87(3):896-903 PMID: 454435
  5. Effect of sodium butyrate on the production of serotonin, histamine and glycosaminoglycans by cultured murine mastocytoma cells.
    Exp Cell Res. 1980 Jun;127(2):465-70 PMID: 6769688
  6. Localization of phosphoproteins and of protein kinases in chromatin from hepatoma tissue-cultured cells.
    Eur J Biochem. 1980 Oct;111(1):237-44 PMID: 7439187
  7. Changes in the frequency and diversity of messenger RNA populations in the course of myogenic differentiation.
    Eur J Biochem. 1979 Jul;97(2):321-6 PMID: 467420
  8. Reorganization of the cytoskeleton by interferon in MSV-transformed cells.
    J Interferon Res. 1981 Feb;1(2):323-32 PMID: 6180063
  9. Butyrate-induced glycolipid biosynthesis in HeLa cells: properties of the induced sialyltransferase.
    Arch Biochem Biophys. 1976 Feb;172(2):618-26 PMID: 4022
  10. Effect of sodium butyrate on mammalian cells in culture: a review.
    In Vitro. 1976 Feb;12(2):125-32 PMID: 2548
  11. Liver chromatin non-histone proteins. Partial fractionation and mechanism of action on RNA synthesis.
    Biochim Biophys Acta. 1972 Sep 14;277(3):576-83 PMID: 5070066
  12. Calf liver nuclear N-acetyltransferases. Purification and properties of two enzymes with both spermidine acetyltransferase and histone acetyltransferase activities.
    J Biol Chem. 1978 Jan 10;253(1):233-7 PMID: 22543
  13. Comparative studies of histone acetylation in nucleosomes, nuclei, and intact cells. Evidence for special factors which modify acetylase action.
    J Biol Chem. 1980 Dec 10;255(23):11454-63 PMID: 7440548
  14. In vitro transcription of chromatin containing histones hyperacetylated in vivo.
    Nucleic Acids Res. 1980 Sep 25;8(18):4201-19 PMID: 7001364
  15. Chromatographic separation of chromatin subunits.
    Biochem Biophys Res Commun. 1974 Dec 23;61(4):1193-8 PMID: 4455255
  16. Segregation of rapidly acetylated histones into a chromatin fraction released from intact nuclei by the action of micrococcal nuclease.
    Nucleic Acids Res. 1980 Apr 25;8(8):1745-63 PMID: 7433128
  17. Processing of newly synthesized histone molecules.
    Science. 1975 Oct 10;190(4210):117-28 PMID: 1166303
  18. Appearance of a chromatin protein during the erythroid differentiation of Friend virus-transformed cells.
    Proc Natl Acad Sci U S A. 1977 Feb;74(2):653-6 PMID: 265529
  19. Enhancement of interferon antitumor action by sodium butyrate.
    Cancer Res. 1979 Nov;39(11):4720-3 PMID: 498098
  20. Different accessibilities in chromatin to histone acetylase.
    J Biol Chem. 1979 Mar 10;254(5):1716-23 PMID: 762168
  21. Fractionation of hen oviduct chromatin into transcriptionally active and inactive regions after selective micrococcal nuclease digestion.
    Cell. 1978 Sep;15(1):141-50 PMID: 699037
  22. Regulation of tyrosine hydroxylase activity in cultured mouse neuroblastoma cells: elevation induced by analogs of adenosine 3':5'-cyclic monophosphate.
    Proc Natl Acad Sci U S A. 1972 Aug;69(8):2241-5 PMID: 4403308
  23. Studies on histone fraction F2A1 in macro- and micronuclei of Tetrahymena pyriformis.
    J Cell Biol. 1973 Jun;57(3):773-81 PMID: 4633445
  24. n-Butyrate causes histone modification in HeLa and Friend erythroleukaemia cells.
    Nature. 1977 Aug 4;268(5619):462-4 PMID: 268489
  25. Induction of the Epstein-Barr virus (EBV) cycle in latently infected cells by n-butyrate.
    Virology. 1979 Apr 15;94(1):228-31 PMID: 220786
  26. Expression of myogenic differentiation and myotube formation by chick embryo myoblasts in the presence of sodium butyrate.
    Exp Cell Res. 1980 Mar;126(1):31-7 PMID: 7358093
  27. Butyric acid suppression of the in vitro neoplastic state of Syrian hamster cells.
    Nature. 1978 Jan 19;271(5642):262-5 PMID: 563982
  28. Postsynthetic modification of high mobility group proteins. Evidence that high mobility group proteins are acetylated.
    J Biol Chem. 1978 Nov 10;253(21):7601-4 PMID: 701276
  29. DNAse I preferentially digests chromatin containing hyperacetylated histones.
    Biochem Biophys Res Commun. 1978 Jun 29;82(4):1346-53 PMID: 697799
  30. Effects of sodium butyrate on the membrane glycoconjugates of murine sarcoma virus-transformed rat cells.
    J Cell Biol. 1980 Feb;84(2):225-34 PMID: 7380882
  31. Modulation of the nucleosome structure by histone acetylation.
    Eur J Biochem. 1980 Sep;110(1):143-52 PMID: 7439155
  32. A correlation between nucleosome spacer region susceptibility to DNase I and histone acetylation.
    Nucleic Acids Res. 1979 Feb;6(2):561-74 PMID: 424305
  33. Butyrate suppression of histone deacetylation leads to accumulation of multiacetylated forms of histones H3 and H4 and increased DNase I sensitivity of the associated DNA sequences.
    Proc Natl Acad Sci U S A. 1978 May;75(5):2239-43 PMID: 276864
  34. Sodium n-butyrate causes reversible decrease in condensed chromatin clumps in HeLa cells.
    Proc Soc Exp Biol Med. 1979 Sep;161(4):543-5 PMID: 482289
  35. Structure of chromatin containing extensively acetylated H3 and H4.
    Cell. 1978 Apr;13(4):691-9 PMID: 657272
  36. Ultrastructural concomitants of sodium butyrate-enhanced ectopic production of chorionic gonadotropin and its alpha subunit human bronchogenic carcinoma (ChaGo) cells.
    J Natl Cancer Inst. 1979 Jan;62(1):45-61 PMID: 281577
  37. Chemically induced gene activation: selective increase in DNAase I susceptibility in chromatin acetylated with acetyl adenylate.
    Biochem Biophys Res Commun. 1978 Sep 29;84(2):342-9 PMID: 718686
  38. Selective inhibition by sodium butyrate of the glucocorticoid induction of glycerol phosphate dehydrogenase in glial cultures.
    Biochem Biophys Res Commun. 1980 Apr 29;93(4):1297-304 PMID: 6772178
  39. Cell cycle-specific enhancement of type C virus activation by sodium n-butyrate.
    Cancer Res. 1980 Nov;40(11):3886-90 PMID: 6258768
  40. Manipulation of myogenesis in vitro: reversible inhibition by DMSO.
    Cell. 1979 May;17(1):95-108 PMID: 455462
  41. Effects of sodium butyrate on synthesis of human chorionic gonadotrophin in trophoblastic and non-trophoblastic tumours.
    Nature. 1977 Aug 11;268(5620):543-4 PMID: 196218
  42. Morphological and biochemical differentiation in HeLa cells. Effects of cycloheximide on butyrate-induced process formation and ganglioside metabolism.
    Exp Cell Res. 1976 Nov;103(1):55-62 PMID: 186290
  43. Effect of sodium butyrate on the granulopoiesis of mastocytoma cells.
    Exp Cell Res. 1979 Jan;118(1):15-22 PMID: 759213
  44. Presence of non-histone proteins in nucleosomes.
    Eur J Biochem. 1978 Aug 1;88(2):583-91 PMID: 689039
  45. Localization of phosphoproteins and of protein kinases in chromatin from butyrate treated HTC cells.
    Biochem Biophys Res Commun. 1980 Nov 28;97(2):530-7 PMID: 7470113
  46. Acetylation of nuclear protein in the heterochromatin and euchromatin of mealy bugs.
    Exp Cell Res. 1972 Mar;71(1):45-8 PMID: 5025943
  47. Histone-specific acetyltransferases from calf thymus. Isolation, properties, and substrate specificity of three different enzymes.
    Biochemistry. 1980 Mar 4;19(5):943-51 PMID: 7356970
  48. Extensive purification of histone acetylase A, the major histone N-acetyl transferase activity detected in mammalian cell nuclei.
    J Biol Chem. 1980 Dec 10;255(23):11448-53 PMID: 7440547
  49. Early reversible nuclear alterations induced by sodium butyrate in cultured hepatoma cells.
    Cell Biol Int Rep. 1980 Oct;4(10):961-8 PMID: 7191351
  50. Concentration-dependent effects of sodium butyrate in Chinese hamster cells: cell-cycle progression, inner-histone acetylation, histone H1 dephosphorylation, and induction of an H1-like protein.
    Biochemistry. 1980 Jun 10;19(12):2656-71 PMID: 7397096
  51. Effect of n-butyrate on DNA synthesis in chick fibroblasts and HeLa cells.
    Cell. 1977 Nov;12(3):855-60 PMID: 562721
  52. A reduction in the degree of H4 acetylation during mitosis in Chinese hamster cells.
    Biochem Biophys Res Commun. 1977 Jul 11;77(1):187-94 PMID: 883971
  53. DNase I sensitive chromatin is enriched in the acetylated species of histone H4.
    FEBS Lett. 1980 Feb 11;110(2):164-8 PMID: 6245919
  54. Constitutive aggregates of intermediate-sized filaments of the vimentin and cytokeratin type in cultured hepatoma cells and their dispersal by butyrate.
    Exp Cell Res. 1980 May;127(1):215-35 PMID: 6155280
  55. Selective digestion of transcriptionally active ovalbumin genes from oviduct nuclei.
    Proc Natl Acad Sci U S A. 1976 Nov;73(11):3966-70 PMID: 1069279
  56. Cell cycle analysis of sodium butyrate and hydroxyurea, inducers of ectopic hormone production in HeLa cells.
    J Cell Physiol. 1979 Aug;100(2):251-62 PMID: 511944
  57. Acetylation and phosphorylation of Drosophila histones. Distribution of acetate and phosphate groups in fractionated chromatin.
    Biochim Biophys Acta. 1977 Mar 2;475(1):168-75 PMID: 191076
  58. Erythroleukemic differentiation.
    Annu Rev Biochem. 1978;47:419-48 PMID: 354501
  59. Butyrate restores fibronectin at cell surface of transformed cells.
    Exp Cell Res. 1980 Jun;127(2):478-81 PMID: 7379876
  60. Induction of human follicle-stimulating hormone in HeLa cells by sodium butyrate.
    Nature. 1977 Jun 2;267(5610):435-7 PMID: 876359
  61. The effect of sodium butyrate on histone modification.
    Cell. 1978 May;14(1):115-21 PMID: 667928
  62. Chromatin subunits contain normal levels of major acetylated histone species.
    J Biol Chem. 1977 Sep 10;252(17):5962-6 PMID: 893392
  63. Sodium butyrate inhibits histone deacetylation in cultured cells.
    Cell. 1978 May;14(1):105-13 PMID: 667927
  64. In vivo-in vitro rat liver carcinogenesis: modifications in protein synthesis and ultrastructure.
    Ann N Y Acad Sci. 1980;349:357-72 PMID: 6164325
  65. Activation of chromatin by acetylation of histone side chains.
    Proc Natl Acad Sci U S A. 1976 Nov;73(11):3937-41 PMID: 1069278
  66. Induction of functional beta-adrenergic receptors in HeLa cells.
    Proc Natl Acad Sci U S A. 1977 Mar;74(3):873-7 PMID: 191837
  67. Thyroid hormone nuclear receptor levels are influenced by the acetylation of chromatin-associated proteins.
    J Biol Chem. 1980 Mar 25;255(6):2499-508 PMID: 6244282
  68. ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS.
    Proc Natl Acad Sci U S A. 1964 May;51:786-94 PMID: 14172992
  69. Differential expression of the globin genes in human leukemia K562(S) cells induced to differentiate by hemin or butyric acid.
    Cancer Res. 1981 Jan;41(1):237-43 PMID: 6934848
  70. Physical properties of chemically acetylated rat liver chromatin.
    Proc Natl Acad Sci U S A. 1977 Aug;74(8):3244-8 PMID: 269387
  71. Effect of sodium butyrate on chromatin structure.
    Biochem Biophys Res Commun. 1980 Apr 14;93(3):833-41 PMID: 7387680
  72. Effect of n-butyrate on cellular and viral DNA synthesis in cells latently infected with Epstein-Barr virus.
    Virology. 1980 Dec;107(2):557-61 PMID: 6256952
  73. Modification of the phenotype of murine sarcoma virus-transformed cells by sodium butyrate. Effects on morphology and cytoskeletal elements.
    Exp Cell Res. 1976 Oct 15;102(2):223-31 PMID: 185074
  74. Nucleosome structure III: the structure and transcriptional activity of the chromatin containing the ovalbumin and globin genes in chick oviduct nuclei.
    Cold Spring Harb Symp Quant Biol. 1978;42 Pt 2:779-91 PMID: 277317
  75. Changes in gene expression accompanying neoplastic transformation of Syrian hamster cells.
    J Biol Chem. 1978 Apr 25;253(8):2497-500 PMID: 632281
  76. Morphology and growth rate changes in Chinese hamster cells cultured in presence of sodium butyrate.
    Exp Cell Res. 1973 Apr;78(2):456-60 PMID: 4349017
  77. Sodium butyrate induces new gene expression in Friend erythroleukemic cells.
    J Biol Chem. 1979 May 25;254(10):4283-90 PMID: 285931
  78. Appearance of beta-adrenergic response of adenylate cyclase during the induction of diffetiation in cell cultures.
    Exp Cell Res. 1979 Sep;122(2):399-402 PMID: 510408
  79. Chromosomal subunits in active genes have an altered conformation.
    Science. 1976 Sep 3;193(4256):848-56 PMID: 948749
  80. Partial inhibition of histone deacetylase in active chromatin by HMG 14 and HMG 17.
    Nucleic Acids Res. 1980 May 10;8(9):1947-63 PMID: 6448990
  81. Multiacetylated forms of H4 are found in a putative transcriptionally competent chromatin fraction from trout testis.
    Nucleic Acids Res. 1979 Jan;6(1):259-74 PMID: 424292
  82. Studies of acetylation and deacetylation in high mobility group proteins. Identification of the sites of acetylation in HMG-1.
    J Biol Chem. 1979 Nov 25;254(22):11577-83 PMID: 500660
  83. Effect of histone acetylation on structure and in vitro transcription of chromatin.
    Nucleic Acids Res. 1978 Oct;5(10):3523-47 PMID: 724494
  84. Effect of DNase I on histone acetyltransferase and deacetylase enzyme activities in Friend cell nuclei: evidence for a putative inhibitor of the deacetylase enzymes in transcriptionally active chromatin.
    Biochem Biophys Res Commun. 1979 Jul 27;89(2):571-9 PMID: 290356
  85. Histone acetylation. Purification and properties of three histone-specific acetyltransferases from rat thymus nuclei.
    Biochim Biophys Acta. 1972 Apr 15;263(2):315-28 PMID: 5031160
  86. Acetylation of histone H4 and its role in chromatin structure and function.
    Nature. 1980 Sep 4;287(5777):76-9 PMID: 7412879
  87. Partial purification of the template-active fraction of chromatin: a preliminary report.
    Proc Natl Acad Sci U S A. 1974 Jun;71(6):2193-7 PMID: 4526205
  88. Type I and type II interferons: differential antiviral actions in transformed cells.
    J Gen Virol. 1980 Feb;46(2):449-54 PMID: 6155431
  89. Interferon production by human lymphoblastoid cells is stimulated by inducers of Friend cell differentiation.
    Virology. 1979 Nov;99(1):158-66 PMID: 227159
  90. The identification of distinct populations of acetylated histone.
    J Biol Chem. 1980 Oct 10;255(19):9110-6 PMID: 7410415
  91. Butyrate and related inhibitors of histone deacetylation block the induction of egg white genes by steroid hormones.
    Cell. 1980 Nov;22(2 Pt 2):469-77 PMID: 7448870
  92. Increase in initiation sites for chromatin directed RNA synthesis by acetylation of chromosomal proteins.
    Biochem Biophys Res Commun. 1978 Sep 14;84(1):110-6 PMID: 365177
  93. Butyric acid, a potent inducer of erythroid differentiation in cultured erythroleukemic cells.
    Cell. 1975 Jul;5(3):319-22 PMID: 1056809
  94. Changes in DNA associated with induction of erythroid differentiation by dimethyl sulfoxide in murine erythroleukemia cells.
    Cancer Res. 1978 Mar;38(3):835-40 PMID: 272229
  95. RNA synthesis and histone acetylation during the course of gene activation in lymphocytes.
    Proc Natl Acad Sci U S A. 1966 Apr;55(4):805-12 PMID: 5219687
  96. Expression of poly(adenosine diphosphate-ribose) polymerase activity in erythroleukemic mouse cells during cell cycle and erythropoietic differentiation.
    J Biol Chem. 1978 Jun 25;253(12):4333-40 PMID: 207697
  97. Induction of glycolipid biosynthesis by sodium butyrate in HeLa cells.
    Biochem Biophys Res Commun. 1974 Jul 10;59(1):292-9 PMID: 4858378
  98. Nucleosome-histone acetyltransferase from rat liver chromatin.
    Biochem Biophys Res Commun. 1980 Feb 27;92(4):1409-14 PMID: 7370043
  99. Acetylated histone H4 is preferentially associated with template-active chromatin.
    Proc Natl Acad Sci U S A. 1978 Aug;75(8):3574-7 PMID: 278972
  100. A study of adenosine 3':5'-cyclic monophosphate, sodium butyrate and cortisol as inducers of HeLa alkaline phosphatase.
    Arch Biochem Biophys. 1974 Oct;164(2):619-23 PMID: 4376666
  101. Properties of an acidic histone-binding protein fraction from cell nuclei. Selective precipitation and deacetylation of histones F2A1 and F3.
    J Biol Chem. 1972 Nov 25;247(22):7365-73 PMID: 4674086
  102. Growth inhibition and morphological changes caused by lipophilic acids in mammalian cells.
    Proc Natl Acad Sci U S A. 1973 Aug;70(8):2457-61 PMID: 4365381
  103. Suppression of histone deacetylation in vivo and in vitro by sodium butyrate.
    J Biol Chem. 1978 May 25;253(10):3364-6 PMID: 649576
  104. Amino acid analysis and cell cycle dependent phosphorylation of an H1-like, butyrate-enhanced protein (BEP; H1(0); IP25) from Chinese hamster cells.
    Biochemistry. 1980 Sep 2;19(18):4331-41 PMID: 7191324
  105. Rapid turnover of acetyl groups in the four core histones of simian virus 40 minichromosomes.
    Proc Natl Acad Sci U S A. 1979 Jan;76(1):46-50 PMID: 218203
  106. Effect of sodium butyrate on the antiviral and anticellular action of interferon in normal and MSV-transformed cells.
    Int J Cancer. 1979 Sep 15;24(3):314-8 PMID: 226485
  107. Breakage of DNA and alterations in folded genomes by inducers of differentiation in Friend erythroleukemic cells.
    Cancer Res. 1978 Mar;38(3):841-9 PMID: 75063
  108. Reversible effects of Na-butyrate on histone acetylation.
    Biochem Biophys Res Commun. 1978 May 15;82(1):223-7 PMID: 666835
  109. Cytochalasin B-induced multinucleation of murine sarcoma virus-transformed cells. Inhibition by sodium butyrate.
    Exp Cell Res. 1979 Jan;118(1):31-7 PMID: 215423
  110. Carcinogen-induced abnormalities in rat liver cells and their modification by chemical agents.
    Cancer Res. 1979 Mar;39(3):800-7 PMID: 427768
  111. Changing patterns of histone acetylation and RNA synthesis in regeneration of the liver.
    Proc Natl Acad Sci U S A. 1968 Apr;59(4):1337-44 PMID: 5240033
  112. Immunochemical characterization of Epstein-Barr virus-associated early and late antigens in n-butyrate-treated P3HR-1 cells.
    J Virol. 1979 Dec;32(3):710-6 PMID: 229261
  113. Histone acetylation during meiosis in Lilium microsporocytes.
    Exp Cell Res. 1976 Sep;101(2):283-92 PMID: 964310
  114. Studies on the mechanism of butyrate-induced morphological changes in KB cells.
    Exp Cell Res. 1978 Nov;117(1):95-102 PMID: 720409
  115. DNA associated with hyperacetylated histone is preferentially digested by DNase I.
    Nucleic Acids Res. 1978 Jun;5(6):1863-76 PMID: 673837
  116. Biosynthesis and function of gangliosides.
    Science. 1976 Nov 26;194(4268):906-15 PMID: 185697
  117. Cells inhibited by n-butyrate support adenovirus replication.
    Virology. 1980 Dec;107(2):514-9 PMID: 7456334
  118. Comparative studies on highly metabolically active histone acetylation.
    Biochim Biophys Acta. 1979 Jan 26;561(1):248-60 PMID: 105758
  119. Modulation of glucocorticoid effects and steroid receptor binding in butyrate-treated HeLa S3 cells.
    Arch Biochem Biophys. 1980 Apr 15;201(1):174-84 PMID: 7396495
Article Info
Journal
Molecular and cellular biochemistry
Abbr.
Mol Cell Biochem
ISSN
0300-8177
DOI
10.1007/BF00222695
Published
1982-02-05
Pages
65-82
Language
English
Region
Netherlands
NLM ID
0364456
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00222695 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2