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PMID: 1069278 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Activation of chromatin by acetylation of histone side chains.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 11 ·1976-11-00 ·Pages 3937-41

Marushige K

Abstract

The ability of calf thymus chromatin to support DNA-dependent RNA synthesis is markedly increased by modification of the histones with acetic anhydride. The extent of chemical acetylation of histones H2a, H2b, H3, and H4 required for the increase of template activity of the chromatin is within that which can be achieved enzymatically in the cell. The evidence suggests that the acetylation of histone side chains stimulates the rate of chain elongation during transcription of chromatin.

MeSH Terms
Acetylation Animals Cattle Chromatin/metabolism DNA-Directed RNA Polymerases/metabolism Histones/metabolism Structure-Activity Relationship Templates, Genetic Thymus Gland Transcription, Genetic
Chemicals
Chromatin Histones DNA-Directed RNA Polymerases
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Marushige K
References (24)
24 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.73.11.3937
Published
1976-11-00
Pages
3937-41
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC431273
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.73.11.3937 PMC Full Text View journal details
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