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PMID: 457275 Published · ppublish English Journal Article

Stimulation of the reticuloendothelial system of mice by muramyl dipeptide.

Infection and immunity ·Vol. 24 ·No. 2 ·1979-05-00 ·Pages 302-7

Tanaka A, Nagao S, Nagao R, Kotani S, Shiba T, Kusumoto S

Abstract

Muramyl dipeptide (MDP), a part of bacterial cell wall peptidoglycans, was active as adjuvant and stimulated the reticuloendothelial system (RES) of mice to increase its phagocytic function. A series of analogs of MDP was tested for their adjuvant activity and RES-stimulating activity. Sex differences were observed in the adjuvant activity and RES-stimulating capacity of some MDP analogs. A stereochemically highly specific structure required for MDP to exert adjuvant activity was also required for its RES-stimulating activity. Based on this close correlation among the structure, adjuvant activity, and RES-stimulating capacity of MDP, we infer that macrophages may play an important role in the expression of adjuvant activity of MDP.

MeSH Terms
Acetylmuramyl-Alanyl-Isoglutamine/pharmacology Adjuvants, Immunologic Animals Antibody Formation/drug effects Female Glycopeptides/pharmacology Male Mice Mononuclear Phagocyte System/drug effects Phagocytosis/drug effects Sex Factors Structure-Activity Relationship
Chemicals
Adjuvants, Immunologic Glycopeptides Acetylmuramyl-Alanyl-Isoglutamine
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Tanaka A
Nagao S
Nagao R
Kotani S
Shiba T
Kusumoto S
References (31)
31 references, click to expand
  1. [STIMULATION OF THE PHAGOCYTIC ACTIVITY OF THE RETICULOENDOTHELIAL SYSTEM BY CORYNEBACTERIUM PARVUM].
    J Reticuloendothel Soc. 1964 Jan;1:77-96 PMID: 14171321
  2. Effect of Mycobacterium phlei upon reticuloendothelial system of mice of different ages.
    Proc Soc Exp Biol Med. 1963 Mar;112:651-4 PMID: 14027679
  3. [Influence of sex hormones on the stimulation of the phagocytic function of the reticuloendothelial system induced by inoculation of the Calmette-Guerin bacillus (BCG) in the mouse].
    C R Seances Soc Biol Fil. 1960;154:1994-2001 PMID: 13710909
  4. [Estrogens and phagocytic function of the reticuloendothelial system].
    C R Seances Soc Biol Fil. 1957;151(7):1326-31 PMID: 13523896
  5. Effect of bacterial endotoxins on the reticuloendothelial system.
    Fed Proc. 1957 Sep;16(3):860-7 PMID: 13480376
  6. The effect of Salm. typhi and its endotoxin on the phagocytic activity of the reticuloendothelial system in mice.
    Br J Exp Pathol. 1955 Jun;36(3):226-35 PMID: 13239977
  7. Immunoadjuvant activities of synthetic 6-O-acyl-N-acetylmuramyl-L-alanyl-D-isoglutamine with special reference to the effect of its administration with liposomes.
    Biken J. 1977 Dec;20(3-4):95-103 PMID: 614856
  8. Correlation of structure and adjuvant activity of N-acetyl muramyl-L-alanyl-D-isoglutamine (MDP), its derivatives and analogues. Anti-adjuvant and competition properties of stereoisomers.
    Biochem Biophys Res Commun. 1976 Sep 7;72(1):339-46 PMID: 985477
  9. Correlation of stereochemically specific structure in muramyl dipeptide between macrophage activation and adjuvant activity.
    Biochem Biophys Res Commun. 1977 Jul 25;77(2):621-7 PMID: 901491
  10. Adjuvanticity (immunity-inducing property) of cord factor in mice and rats.
    Infect Immun. 1977 Jun;16(3):725-9 PMID: 70404
  11. Granuloma formation by synthetic bacterial cell wall fragment: muramyl dipeptide.
    Infect Immun. 1978 Feb;19(2):613-20 PMID: 75847
  12. Enhancement of nonspecific immunity to Klebsiella pneumoniae infection by a synthetic immunoadjuvant (N-acetylmuramyl-L-alanyl-D-isoglutamine) and several analogs.
    Proc Natl Acad Sci U S A. 1977 May;74(5):2089-93 PMID: 325566
  13. Target cells for the activity of a synthetic adjuvant: muramyl dipeptide.
    Cell Immunol. 1977 Mar 1;29(1):195-9 PMID: 321136
  14. Effect of a synthetic adjuvant on the induction of primary immune responses in T cell-depleted spleen cultures.
    J Immunol. 1978 Jul;121(1):383-9 PMID: 307582
  15. Mitogenic activity of adjuvant-active N-acetylmuramyl-L-alanyl-D-isoglutamine and its analogues.
    Biken J. 1977 Jun;20(2):81-5 PMID: 563229
  16. Inhibition of macrophage migration by synthetic muramyl dipeptide.
    Biochem Biophys Res Commun. 1978 Feb 28;80(4):923-8 PMID: 637877
  17. Adjuvant activity of synthetic N-acetylmuramyl peptides in rats.
    Infect Immun. 1977 Jan;15(1):332-4 PMID: 832904
  18. Nonspecific macrophage activation by systemic adjuvants. Evaluation by lysosomal enzyme and in vitro tumoricidal activities.
    Int Arch Allergy Appl Immunol. 1976;51(5):594-607 PMID: 786904
  19. Immunologic events during Listeria monocytogenes infection in mice: adjuvanticity and immunogenicity of macrophage-bound antigens.
    J Immunol. 1973 Mar;110(3):829-34 PMID: 4631873
  20. The adjuvant activity of a mycobacterial water soluble adjuvant (WSA) in vitro. I. The requirement of macrophages.
    J Immunol. 1974 Jul;113(1):395-403 PMID: 4134068
  21. The use of a wate-soluble carbodiimide as a coupling reagent in the passive hemagglutination test.
    J Immunol. 1966 Dec;97(6):791-6 PMID: 4163006
  22. Studies on the induction of immunologic unresponsiveness. I. Effects of endotoxin and phytochemagglutinin.
    J Immunol. 1967 Jun;98(6):1241-7 PMID: 4165231
  23. Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives.
    Biochem Biophys Res Commun. 1974 Aug 19;59(4):1317-25 PMID: 4606813
  24. Comparison between macrophage activation and enhancement of nonspecific resistance to tumors by mycobacterial immunoadjuvants.
    Proc Natl Acad Sci U S A. 1975 Oct;72(10):4105-9 PMID: 812088
  25. Adjuvant activity of mycobacterial fractions: adjuvant activity of synthetic N-acetylmuramyl-dipeptide and the related compounds.
    Infect Immun. 1976 Jul;14(1):18-27 PMID: 820642
  26. Modulation of the immune response by a synthetic adjuvant and analogs.
    Proc Natl Acad Sci U S A. 1976 Jul;73(7):2472-5 PMID: 1065901
  27. The role of macrophages in the adjuvant effect on antibody production of Corynebacterium parvum.
    Clin Exp Immunol. 1976 Jan;23(1):149-53 PMID: 770033
  28. Correlation between the immunoadjuvant activities and pyrogenicities of synthetic N-acetylmuramyl-peptides or -amino acids.
    Biken J. 1976 Mar;19(1):9-13 PMID: 779765
  29. Immunoadjuvant activities of synthetic N-acetyl-muramyl-peptides or -amino acids.
    Biken J. 1975 Jun;18(2):105-11 PMID: 1180867
  30. Genetic control of macrophage functions. I. Polygenic regulation of phagocytosis stimulation produced by Glyceryl Trioleate.
    J Exp Med. 1975 Feb 1;141(2):306-21 PMID: 1113063
  31. Stimulation of phagocytosis in relation to the mechanism of action of adjuvants.
    Nature. 1966 Mar 12;209(5028):1142-3 PMID: 5925202
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.24.2.302-307.1979
Published
1979-05-00
Pages
302-7
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC414301
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.24.2.302-307.1979 PMC Full Text View journal details
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