Adjuvant activity of synthetic N-acetylmuramyl peptides in rats.

Infection and immunity ·Vol. 15 ·No. 1 ·1977-01-00 ·Pages 332-4

Tanaka A, Saito R, Sugiyama K, Morisaki I, Kotani S

Abstract

The minimal adjuvant-active structure in bacterial cell wall peptidoglycan for the induction of delayed hypersensitivity in rats (WKA) was the N-acetylmuramyl dipeptides (N-acetylmuramyl L-alanyl-D-isoglutamine and N-acetylmuramyl L-alanyl-D-glutamic acid).

MeSH Terms

Adjuvants, Immunologic Animals Glycopeptides/pharmacology Hypersensitivity, Delayed/immunology Peptidoglycan/pharmacology Rats Skin Tests

Chemicals

Adjuvants, Immunologic Glycopeptides Peptidoglycan

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Tanaka A

Saito R

Sugiyama K

Morisaki I

Kotani S

References (5)

5 references, click to expand

Adjuvant activity in delayed hypersensitivity of the peptidic part of bacterial peptidoglycans.
Nature. 1974 Aug 9;250(5466):517-8 PMID: 4219951
Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives.
Biochem Biophys Res Commun. 1974 Aug 19;59(4):1317-25 PMID: 4606813
Adjuvant effect of cord factor, a mycobacterial lipid.
Infect Immun. 1976 Mar;13(3):776-81 PMID: 818016
Immunoadjuvant activities of synthetic N-acetyl-muramyl-peptides or -amino acids.
Biken J. 1975 Jun;18(2):105-11 PMID: 1180867
Distinctive adjuvanticity of synthetic analogs of mycobacterial water-soluble components.
Cell Immunol. 1976 Feb;21(2):243-9 PMID: 1260863

Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.15.1.332-334.1977

Published

1977-01-00

Pages

332-4

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC421367

Subset

External Links

PubMed source DOI: 10.1128/iai.15.1.332-334.1977 PMC Full Text View journal details

Analysis Services

Adjuvant activity of synthetic N-acetylmuramyl peptides in rats.

Contact

WeChat Official Account