Comparison between macrophage activation and enhancement of nonspecific resistance to tumors by mycobacterial immunoadjuvants.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 72 ·No. 10 ·1975-10-00 ·Pages 4105-9

Juy D, Chedid L

Abstract

It has repeatedly been observed that various bacterial preparations could increase the host's resistance to tumors. It has also been shown that after nonspecific activation by BCG (bacillus Calmette-Guérin), peritoneal macrophages could inhibit in vitro the growth of neoplastic target cells. In the present study a fraction extracted from Myobacterium smegmatis and referred to as interphase material was tested in view of measuring its ability to activate macrophages in vitro and in vivo. This preparation was previously shown to protect mice against a syngeneic leukemia and to increase the immune response of the guinea pig. Other water-soluble adjuvants devoid of demonstrable antitumor activity in vivo were also assayed. The results argue in favor of a correlation between adjuvant activity and the capacity of activating macrophages. Moreover, interphase material administered in vivo consistently induced stronger and more persistent stimulations of macrophages than the other preparations assayed.

MeSH Terms

Adjuvants, Immunologic/pharmacology,therapeutic use Animals Cell Division/drug effects Macrophages/drug effects,immunology,metabolism Mast-Cell Sarcoma/drug therapy,immunology,metabolism Mice Mycobacterium/immunology Neoplasms, Experimental/drug therapy,immunology,metabolism Thymidine/metabolism

Chemicals

Adjuvants, Immunologic Thymidine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Juy D

Chedid L

References (25)

25 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.72.10.4105

Published

1975-10-00

Pages

4105-9

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC433147

Subset

External Links

PubMed source DOI: 10.1073/pnas.72.10.4105 PMC Full Text View journal details

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Comparison between macrophage activation and enhancement of nonspecific resistance to tumors by mycobacterial immunoadjuvants.

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