The role of macrophages in the adjuvant effect on antibody production of Corynebacterium parvum.

Clinical and experimental immunology ·Vol. 23 ·No. 1 ·1976-01-00 ·Pages 149-53

Watson SR, Sljivić VS

Abstract

Spleen cells from mice pre-treated with C. parvum gave an enhanced in vitro antibody response to SRBC, but not to DNP-POL. This enhancing activity was associated with the adherent, but not the non-adherent spleen cell population and was found to be radioresistant. It is concluded that macrophages are directly involved in the adjuvant effect of C. parvum and the possible mechanisms of action are discussed.

MeSH Terms

Adjuvants, Immunologic Animals Antibodies, Bacterial/biosynthesis Antibody Formation Antibody-Producing Cells Antigens Cell Adhesion Dinitrophenols Erythrocytes/immunology Female Hemolytic Plaque Technique In Vitro Techniques Macrophages/immunology Mice Mice, Inbred CBA Propionibacterium acnes/immunology Radiation Effects Spleen/cytology,radiation effects

Chemicals

Adjuvants, Immunologic Antibodies, Bacterial Antigens Dinitrophenols

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Watson S R

Sljivić V S

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23 references, click to expand

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Article Info

Journal

Clinical and experimental immunology

Abbr.

Clin Exp Immunol

ISSN

0009-9104

Published

1976-01-00

Pages

149-53

Language

English

Region

England

NLM ID

0057202

PMCID

PMC1538357

Subset

External Links

PubMed source PMC Full Text View journal details

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The role of macrophages in the adjuvant effect on antibody production of Corynebacterium parvum.

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