Further analysis of the anti-tumour effect in vitro of peritoneal exudate cells from mice treated with Corynebacterium parvum.

British journal of cancer ·Vol. 31 ·No. 1 ·1975-01-00 ·Pages 15-24

Ghaffar A, Cullen RT, Woodruff MA

Abstract

Administration of C. parvum to both intact and thymectomized mice resulted in the appearance in the peritoneal exudate of cells which inhibited tumour growth in vitro. This effect was mediated by intact, viable adherent cells, which it seems reasonable to categorize as macrophages, and was contingent on contact between the effector and target cells. No co-operation was observed between lymph node cells from C. parvum treated mice and peritoneal exudate cells from normal mice.

MeSH Terms

Animals Ascitic Fluid/cytology Cell Adhesion Cytotoxicity Tests, Immunologic Female Fibrosarcoma/immunology Freezing Immunity, Cellular In Vitro Techniques Lymph Nodes/immunology Macrophages/immunology Mice Mice, Inbred CBA Propionibacterium acnes/immunology Sarcoma, Experimental/immunology Thymectomy

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Ghaffar A

Cullen R T

Woodruff M A

References (11)

11 references, click to expand

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Tumour growth and non-specific immunity in rats: the mechanisms involved in inhibition of tumour growth.
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Article Info

Journal

British journal of cancer

Abbr.

Br J Cancer

ISSN

0007-0920

DOI

10.1038/bjc.1975.3

Published

1975-01-00

Pages

15-24

Language

English

Region

England

NLM ID

0370635

PMCID

PMC2009347

Subset

External Links

PubMed source DOI: 10.1038/bjc.1975.3 PMC Full Text View journal details

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Further analysis of the anti-tumour effect in vitro of peritoneal exudate cells from mice treated with Corynebacterium parvum.

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