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PMID: 70404 Published · ppublish English Journal Article

Adjuvanticity (immunity-inducing property) of cord factor in mice and rats.

Infection and immunity ·Vol. 16 ·No. 3 ·1977-06-00 ·Pages 725-9

Saito R, Nagao S, Takamoto M, Sugiyama K, Tanaka A

Abstract

Cord factor, a glycolipid in mycobacteria, was found to make a tolerogenic protein antigen immunogenic when injected 0 to 2 days before tolerogen injection in mice and rats. Cord factor was also found to increase phagocytic function of the reticuloendothelial system of mice, and the relationship between the immunity-inducing capacity and the phagocytic function is discussed.

MeSH Terms
Adjuvants, Immunologic Animals Antibody Formation/drug effects Cattle/immunology Cord Factors/pharmacology Female Glycolipids/pharmacology Immune Tolerance/drug effects Immunization Mice Mononuclear Phagocyte System/immunology Phagocytosis/drug effects Rats Skin Tests gamma-Globulins
Chemicals
Adjuvants, Immunologic Cord Factors Glycolipids gamma-Globulins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Saito R
Nagao S
Takamoto M
Sugiyama K
Tanaka A
References (23)
23 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.16.3.725-729.1977
Published
1977-06-00
Pages
725-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC421020
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.16.3.725-729.1977 PMC Full Text View journal details
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