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PMID: 75847 Published · ppublish English Comparative Study Journal Article

Granuloma formation by synthetic bacterial cell wall fragment: muramyl dipeptide.

Infection and immunity ·Vol. 19 ·No. 2 ·1978-02-00 ·Pages 613-20

Emori K, Tanaka A

Abstract

A synthetic muramyl dipeptide, N-acetylmuramyl-L-alanyl-D-isoglutamine, which possesses the same structure as that of a part of the peptidoglycan monomer of wax D of tubercle bacilli or bacterial cell walls was found to induce, when injected in water-in-oil emulsion, massive granulomas often accompanying abscesses in the site of injection and draining lymph nodes of guinea pigs and rats. The granulomas were composed mainly of epithelioid cells 2 weeks after injection and were indistinguishable from those induced by tubercle bacilli. The granulomas induced in rats were less mature than those induced in guinea pigs. Allergic reaction appeared to play no important role in the development of the muarmyl dipeptide-induced granuloma.

MeSH Terms
Animals Epitopes Female Glycopeptides/adverse effects,immunology Granuloma/chemically induced,pathology Guinea Pigs Lymph Nodes/pathology Mycobacterium tuberculosis Rats Tuberculoma/pathology
Chemicals
Epitopes Glycopeptides
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Emori K
Tanaka A
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24 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.19.2.613-620.1978
Published
1978-02-00
Pages
613-20
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC414127
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.19.2.613-620.1978 PMC Full Text View journal details
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