Role of cord factor (trehalose-6,6'-dimycolate) in allergic granuloma formation in rabbits.

Infection and immunity ·Vol. 6 ·No. 1 ·1972-07-00 ·Pages 5-8

Moore VL, Myrvik QN, Kato M

Abstract

The role of cord factor in BCG-induced pulmonary granulomas and local pulmonary delayed hypersensitivity (DH) was evaluated. Cord factor did not induce pulmonary granulomas comparable to those induced by killed BCG. The compound did not induce pulmonary DH that could be elicited by itself, purified protein derivative, or BCG. Cord factor-injected animals did not develop an accelerated pulmonary granulomatous response after challenge with killed BCG. Finally, cord factor did not elicit local pulmonary DH in BCG-sensitized animals. These results are discussed in relation to cord factor's role in antimicrobial immunity, granuloma formation, and antitumor immunity.

MeSH Terms

Animals Bacterial Vaccines/adverse effects Glycolipids/pharmacology Granuloma/microbiology,pathology Hypersensitivity, Delayed/pathology Lung/drug effects,pathology Mycobacterium bovis/immunology Rabbits

Chemicals

Bacterial Vaccines Glycolipids

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Moore V L

Myrvik Q N

Kato M

References (19)

19 references, click to expand

Migratory response of granulomatous alveolar cells from BCG-sensitized rabbits.
J Immunol. 1970 Jul;105(1):227-37 PMID: 5425345
Cellular reaction in the footpad and draining lymph nodes of mice induced by mycobacterial fractions and BCG bacilli.
Infect Immun. 1971 Sep;4(3):245-55 PMID: 4949489
Studies on the chemistry of the cord factor of Mycobacterium tuberculosis.
J Biol Chem. 1955 May;214(1):251-65 PMID: 14367384
Suppression of urethan-induced lung adenomas in mice treated with trehalose-6,6-dimycolate (cord factor) and living bacillus Calmette Guérin.
Science. 1971 Dec 17;174(4015):1240-2 PMID: 5002466
Granuloma formation around schistosome eggs as a manifestation of delayed hypersensitivity.
Am J Pathol. 1967 Nov;51(5):735-56 PMID: 6054847
Immune response to sheep red blood cells in mice pretreated with mycobacterial fractions.
Infect Immun. 1971 Sep;4(3):256-63 PMID: 4949490
Effect of antimacrophage serum on dermal tuberculin sensitivity and allergic pulmonary granuloma formation in rabbits.
Infect Immun. 1970 Dec;2(6):810-4 PMID: 16557920
A study of macrophages and epitheloid-like cells from granulomatous (BCG-induced) lungs of rabbits.
J Immunol. 1962 Nov;89:745-51 PMID: 13936993
Studies of a biochemical lesion in experimental tuberculosis in mice. V. Further study on a toxic lipid fraction in firmly bound lipids.
Am Rev Respir Dis. 1967 Sep;96(3):460-8 PMID: 4292304
Granuloma formation induced in mice by chemically defined mycobacterial fractions.
J Bacteriol. 1969 Oct;100(1):95-102 PMID: 4981067
The inhibition of granuloma formation around Schistosoma mansoni eggs. 3. Heterologous antilymphocyte serum.
Am J Pathol. 1968 Mar;52(3):613-31 PMID: 5651224
Acute granulomatous response produced in mice by trehalose-6,6-dimycolate.
J Bacteriol. 1968 Oct;96(4):958-61 PMID: 4971895
Studies on pulmonary alveolar macrophages from the normal rabbit: a technique to procure them in a high state of purity.
J Immunol. 1961 Feb;86:128-32 PMID: 13727273
DISSOCIATION OF TUBERCULIN HYPERSENSITIVITY AS MEDIATOR FOR AN ACCELERATED PULMONARY GRANULOMATOUS RESPONSE IN RABBITS.
J Immunol. 1964 Sep;93:433-8 PMID: 14218602
Factors in delayed sensitivity: lymphocyte and macrophage cytotoxins in the tuberculin reaction.
J Immunol. 1969 Sep;103(3):570-6 PMID: 5805437
The inhibition of granuloma formation around Schistosoma mansoni eggs. II. Thymectomy.
Am J Pathol. 1967 Nov;51(5):757-67 PMID: 4861526
Antibody formation to trehalose-6,6'-dimycolate (cord factor) of Mycobacterium tuberculosis.
Infect Immun. 1972 Feb;5(2):203-12 PMID: 4117880
The inhibition of granuloma formation around Schistosoma mansoni eggs. I. Immunosuppressive drugs.
Am J Trop Med Hyg. 1967 May;16(3):284-92 PMID: 6023684
Specific suppression of tumor growth by isolated peritoneal macrophages from immunized mice.
J Immunol. 1965 Oct;95(4):656-64 PMID: 5320526

Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.6.1.5-8.1972

Published

1972-07-00

Pages

5-8

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC422481

Subset

External Links

PubMed source DOI: 10.1128/iai.6.1.5-8.1972 PMC Full Text View journal details

Analysis Services

Role of cord factor (trehalose-6,6'-dimycolate) in allergic granuloma formation in rabbits.

Contact

WeChat Official Account